Broad Institute

MARCH 6, 2024

Related news New project aims to map cellular variation in the healthy human brain Researchers from the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with schizophrenia and from older adults.

Medical Schools

Broad Institute

JUNE 18, 2024

By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips and CRISPR enzymes to identify specific sequences of viral RNA in samples. Then, in 2022, they began adapting the assay to detect other viruses they knew were always circulating: influenzas.

Virus

Broad Institute

AUGUST 31, 2023

We were surprised to see that just missing one copy of this gene can induce many changes at the RNA level, at the protein level, at the functional level, and at the behavioral level,” said Farsi. The scientists also found reduced levels of an enzyme that degrades dopamine, providing further evidence for dopamine’s role in the disorder.

RNA

Broad Institute

OCTOBER 23, 2024

By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.

DNA

Broad Institute

AUGUST 19, 2024

Using RNA sequencing and working with the Broad’s Metabolomics Platform and collaborators at St. I’m so proud of this team and the partnership we formed to follow the science and set up some major positive impacts on women’s health,” Blainey said.

Hospitals

Broad Institute

OCTOBER 17, 2024

The method, called Genotypic and Phenotypic Antibiotic Susceptibility Testing through RNA detection, or GoPhAST-R, analyzes the growth and genetic activity of the bacteria to quickly determine the pathogen’s susceptibility to various medicines.

RNA

Broad Institute

MARCH 8, 2024

First author Zoë Levine is an MD-PhD candidate at Harvard Medical School and graduate student in the lab of Pardis Sabeti at the Broad. Tags: Infectious Disease DNA sequencing RNA sequencing Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing. Nature Communications.

Research

Broad Institute

JUNE 30, 2023

Related Articles Study finds how a genetic variant raises diabetes risk through an unexpected mechanism Related People Anne Carpenter Melina Claussnitzer Related programs Imaging Platform Metabolism Program Novo Nordisk Foundation Center for Genomic Mechanisms of Disease The field of microscopy has advanced immensely over the last fifty years in its (..)

Small Molecule

Drug Target Review

AUGUST 16, 2024

After medical school and residency I decided to dedicate my life to women and specialised in obstetrics and gynaecology. I graduated with my BS in physiology and later attended the University of Michigan Medical School.

Medical Schools

Drug Target Review

JUNE 6, 2023

Delivery of therapy is being evaluated through injections of DNA and RNA encoding IL-12, viral vectors, and other exploratory platforms designed to bring IL-12 in close proximity to the tumour and avoid excessive IL-12 in systemic circulation. Some approaches have already reached the clinical trial stage, with others not far behind.

Engineering

The Pharma Data

NOVEMBER 22, 2020

. “Operationally, you design a stretch of 20 [nucleotide] base pairs that match a gene that you want to edit,” George Church, a professor of genetics at Harvard Medical School, told the news source. Once the DNA has been cut, the cell’s natural repair mechanisms kick in.

DNA

The Pharma Data

DECEMBER 13, 2020

Dr. Zhang completed his postdoctoral fellowship at Harvard Medical School/Boston Children’s Hospital. Prior to that, he held various oncology research and development positions at Merrimack Pharmaceuticals and Archemix. He received his B.S. degree from Henan Normal University, M.S. degree from Chinese Academy of Sciences and Ph.D.

Medical Schools

Broad Institute

JUNE 21, 2023

Cell Painting uses six fluorescent dyes to image eight different components of a cell: the nucleus, nucleoli, mitochondria, endoplasmic reticulum (ER), golgi apparatus, cytoplasmic RNA, f-actin cytoskeleton, and plasma membrane.

Small Molecule

The Pharma Data

APRIL 22, 2023

” Uncovering cancer immune system suppression: A three-part investigation As the basis of their investigation, the team profiled primary and metastatic lymph node tumours from 14 patients with head and neck squamous cell cancers, using single cell RNA sequencing.

Medical Schools

Drug Target Review

JULY 1, 2024

Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing. He was bestowed the 2024 NIH HEAL Director’s Trailblazer Award for this work.

Treatment

Broad Institute

DECEMBER 6, 2023

Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. Tags: Cell Circuits Program Immunology RNA sequencing The reference, called the Immune Dictionary , appears today in Nature. Online December 6, 2023.

Immune Response

Broad Institute

AUGUST 14, 2023

In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center.

DNA

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs.

RNA

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.

Science

KIF1A

MAY 4, 2024

Later, she developed an interest in the RNA world, specifically focusing on alternative splicing and its correlation with neuron cell properties within and across cell types. Her undergraduate research focused on lipid metabolism of NASH at UCSD Medical School and DNA breakage and repair mechanism at Scripps Research.

Science

Drug Target Review

AUGUST 28, 2024

We then incubate the cells to mature into ‘pro-regenerative’ macrophages and insert two RNA messages to produce two human proteins that will be expressed at the site of injury when these ‘engineered’ macrophages are given back to the patient. The patient’s own monocytes, a type of white blood cell, are removed via an apheresis procedure.

Therapies

Broad Institute

SEPTEMBER 28, 2023

Beth Stevens , an institute member at the Broad, an associate professor at Harvard Medical School, and a research associate in neurobiology at Boston Children’s Hospital, was a co-author on the study as well.

Disease

Broad Institute

NOVEMBER 20, 2024

Isselbacher Professor of Medicine at Harvard Medical School, director of the Center for Computational and Integrative Biology and member of the Department of Molecular Biology at MGH, and co-director of the Center for Microbiome Informatics and Therapeutics at MIT.

Regulations

The Pharma Data

DECEMBER 5, 2020

The first of the new therapies, developed at Harvard Medical School by a team led by Dr. David Williams, uses a virus to introduce RNA into the extracted bone marrow that turns off BCL11A.

Therapies

Broad Institute

JUNE 13, 2023

To better understand this process, researchers did a deep dive into the genetics of patients' bone marrow, blood, and skin leukemia cells – sequencing the DNA and RNA in individual cells. "We

Hospitals

Codon

JUNE 26, 2023

A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. RNA-guided nucleases, called HERMES, are common across eukaryotes and the viruses that infect them. Paper by Sha G. in Nature.

DNA

Codon

JUNE 26, 2023

A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. RNA-guided nucleases, called HERMES, are common across eukaryotes and the viruses that infect them. Paper by Sha G. in Nature.

DNA

Broad Institute

JANUARY 30, 2024

He saw how genomic technology had progressed during the seven years he’d spent in medical school, spawning discoveries like new mutations underlying leukemia, and he wanted to bring the same capabilities to the study of infectious disease.

Hospitals

PLOS: DNA Science

JULY 27, 2023

Harvard Medical School researchers recently described an “AI tool” that “Decodes Brain Cancer’s Genome During Surgery,” in the journal Med. But, they have genomes, built of RNA or DNA. I was in graduate school for my PhD in genetics when the first virus genome sequences were published.

Disease

The Pharma Data

DECEMBER 23, 2020

One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. is so sporadic,” Jeremy Luban, a virologist at the University of Massachusetts Medical School, told the Post. “It may very well be here. The sequencing in the U.S.

Vaccine

PLOS: DNA Science

FEBRUARY 29, 2024

But maternal genetic information, in the form of messenger RNA “transcripts,” still guides development. Acceptance into (a) preschool (b) college or (c) medical school; marriage; a career begins; when grown offspring leave home. Cleavage divisions ensue. Social milestones. My answer? #14.

DNA

The Pharma Data

DECEMBER 28, 2020

One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. is so sporadic,” Jeremy Luban, a virologist at the University of Massachusetts Medical School, told the Post. “It may very well be here. The sequencing in the U.S.

Vaccine

keypoint

JANUARY 8, 2025

Dr. Cheruiyot is a post-doctoral fellow at the Joslin Diabetes Center, Harvard Medical School (HMS) I n the lab of Dr. Jean Schaffer, s he studies molecular mechanisms underlying protein synthesis in pancreatic beta cells, and alterations of such mechanisms in diabetes.

Medical Schools

Elrig

MARCH 10, 2025

The free-to-attend event will bring together scientists, researchers and entrepreneurs from across the drug discovery community working on proteins, RNA, cell and gene therapies, PROTACs, as well as the application of big data to support target identification, biomarkers and the development of big molecules.

Research

Broad Institute

JANUARY 16, 2025

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntingtons disease leads to the death of brain cells. Funding This work was supported by CHDI Foundation, Inc.,

Disease

Broad Institute

NOVEMBER 6, 2024

Tags: Cancer RNA sequencing

Immune Response

Broad Institute

JANUARY 7, 2025

At the Broad, Rehm wears many hats: chief medical officer for Broad Clinical Labs, a co-leader of Broads Center for Mendelian Genomics , and head of the Translational Genomics Group , a research effort that aims to understand the genetic basis of rare disease.

Disease