Broad Institute

FEBRUARY 24, 2025

Although this ancestral replicase appears to have been lost, key aspects of RNA-catalyzed RNA replication can be studied by proxy with the use of modern RNA enzymes (ribozymes) generated by in vitro evolution.

RNA 52

RNA Molecular Biology Laboratories Engineering 52

Broad Institute

OCTOBER 23, 2024

By applying machine learning and molecular biology to the logic of when and where CREs work, we can leverage that knowledge using generative AI to build tools for modulating gene expression in new ways experimentally and, perhaps one day, therapeutically." Chan School of Public Health. "By

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Research DNA Laboratories Molecular Biology 136

DrugBank

MAY 15, 2024

But as molecular biology has advanced, so too has our approach to finding new drugs. Another promising avenue is the use of technologies like RNA interference and gene editing, which allow scientists to turn off the production of certain proteins altogether. This method was more about serendipity than science.

Small Molecule 99

Small Molecule Molecular Biology Drugs Disease 99

The Pharma Data

JANUARY 19, 2021

In the paper, researchers from Johns Hopkins University and elsewhere found a natural long-form transactivating CRISPR RNA (tracr-L) in Streptococcus pyogenes that functions to downregulate its endogenous CRISPR-Cas9 system. But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts.

Research 52

Research RNA Molecular Biology Small Molecule 52

Drug Target Review

DECEMBER 7, 2023

Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. He continued: “CBASS cyclases look a lot like cGAS, so they have to be sensing something.

RNA 59

RNA Immune Response DNA Molecular Biology 59

Broad Institute

OCTOBER 16, 2024

William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines The groundbreaking, scalable technology is widely used in laboratories around the world today to efficiently produce large amounts of protein and RNA. Merkin (left) and F.

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Vaccine RNA Laboratories Molecular Biology 64

Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Drug Target Review

MAY 27, 2024

By identifying proteins that only interact with each other in cancer, but not normal tissues, we can really expand the repertoire of ADC therapeutics beyond monoclonal antibodies developed based solely on RNA expression profiles.

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Clinical Trials Science Molecular Biology Bioinformatics 59

Elrig

APRIL 29, 2024

She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures. Having a combination of computational skills & scientific knowledge such as molecular biology, genomics is also important.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Alta Sciences

MARCH 1, 2024

PJ: At Altasciences, we have a range of leading-edge platforms that include ligand binding assays (LBA), NAb, TAb, flow cytometry, and ELISpot, as well as on-site molecular biology instrumentation such as Bio-Rad’s ddPCR system, the NanoDropTM One spectrophotometer, and dedicated polymerase chain reaction (PCR) chambers.

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Therapies Laboratories Molecular Biology RNA 52

Drug Target Review

AUGUST 29, 2023

in cell and molecular biology with a focus in cancer biology from the Perelman School of Medicine at the University of Pennsylvania. She is a Business Advisory Board member of the Harvard Institute for RNA Medicine and a member of the Bioscience & Investor Inclusion Group (BIIG) Diverse Talent Network Group.

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Science Disease Molecular Biology Treatment 98

LifeSciVC

JULY 1, 2024

The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein. Here are the twelve pieces of advice for college and early career STEM folks, using scientific metaphors to frame some life lessons I’ve picked up along the way. Remember life’s Central Dogma.

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Science Immune Response Molecular Biology RNA 92

Drug Target Review

JUNE 11, 2024

When choosing my bachelor’s degree, the choice was between pursuing a career in biology or in computer science. Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology.

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Engineering Science Molecular Biology Doctors 65

Drug Target Review

JULY 1, 2024

Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing. He was bestowed the 2024 NIH HEAL Director’s Trailblazer Award for this work.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

Codon

JUNE 25, 2024

Proteins are colored blue and RNA molecules are colored orange and yellow. RNA and proteins comprise each ribosome, but the cell synthesizes these two biomolecules at different rates. Recall that a typical ribosome in bacteria is built from 50 proteins and 3 strands of RNA. The large and small ribosome subunits.

DNA 93

DNA RNA Laboratories Research 93

Codon

APRIL 2, 2024

I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits. The exported RNA could transfect just the target cell.

RNA 57

RNA Engineering Molecular Biology Synthetic Chemistry 57

Broad Institute

NOVEMBER 20, 2024

Isselbacher Professor of Medicine at Harvard Medical School, director of the Center for Computational and Integrative Biology and member of the Department of Molecular Biology at MGH, and co-director of the Center for Microbiome Informatics and Therapeutics at MIT.

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Regulations Immune Response Molecular Biology Medical Schools 84

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

Therapies 59

Therapies RNA Protein Expression DNA 59

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory.

RNA 84

RNA Production Molecular Biology Laboratories 84

The Pharma Data

FEBRUARY 25, 2022

. “The SARS-CoV-2 vaccines target the spike protein, but this protein is under strong selection pressure and, as we have seen with Omicron, can undergo significant mutations,” said Joyce Jose, assistant professor of biochemistry and molecular biology, Penn State. 25) in the journal Communications Biology.

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FDA Approval Molecular Biology FDA Virus 52

Codon

JULY 10, 2024

But in the 1950s, at the dawn of molecular biology, scientists gained a new appreciation for it after searching for organisms that were easy to work with and quick to grow. 1 This singular organism has become the de facto microbe for molecular biology. Before World War II, few scientists used E. coli in their experiments.

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Laboratories DNA Molecular Biology Engineering 92

The Pharma Data

NOVEMBER 10, 2021

By creating genetically finagled mouse models and doing single cell RNA-sequencing, Feng and associates plant that Shp2 was needed by excrescence cells for HCC development, which validated and corroborated allowing that Shp2 presented an ideal target for new cancer curatives.

Disease 52

Disease Molecular Biology RNA Drugs 52

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JUNE 26, 2023

A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JULY 11, 2023

All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It is the untouchable foundation of molecular biology. The ribosome is a molecular printer that threads ‘beads’ onto a protein string. This is simple. And we want to subvert this.

RNA 75

RNA DNA Engineering Laboratories 75

Codon

JULY 11, 2023

All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It is the untouchable foundation of molecular biology. The ribosome is a molecular printer that threads ‘beads’ onto a protein string. This is simple. And we want to subvert this.

RNA 52

RNA DNA Engineering Laboratories 52

Codon

MARCH 12, 2023

But the technologies devised in the process of trying may revolutionize other areas of science, especially reproductive biology. Biology is a Burrito. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. 15 of 31.

DNA 52

DNA Engineering Therapies RNA 52

Broad Institute

JANUARY 30, 2024

He majored in biological chemistry at the University of Chicago and during his junior year, he had a fortuitous meeting with his academic advisor about finding a student research position that would let him dive more deeply into the molecular details of biological systems. A combined MD/PhD program offered both opportunities.

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Hospitals Virus Medical Schools Science 137

Codon

AUGUST 10, 2023

Journal of Molecular Biology (1961). Link (Golden Gate assembly) Other Basic Methods & Cloning →Basic Methods in Cellular and Molecular Biology , by multiple authors. Link Molecular Cloning Techniques , by AddGene. Molecular Biology of the Cell, 4th Edition. . & Xie X.S. Nature (2011).

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Journal of Molecular Biology (1961). Link (Golden Gate assembly) Other Basic Methods & Cloning →Basic Methods in Cellular and Molecular Biology , by multiple authors. Link Molecular Cloning Techniques , by AddGene. Molecular Biology of the Cell, 4th Edition. Molecular Systems Biology (2008).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Broad Institute

APRIL 3, 2025

Our work converts imaging into molecular biology just a reaction in a test tube, said Fei Chen , who is a senior author on the study, a core institute member at the Broad, and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University. Each colored dot represents a different cell type.

DNA 119

DNA RNA Molecular Biology Laboratories 119

addgene Blog

JANUARY 23, 2025

These papers are chock full of great tips to guide your experimental design, especially the desig n of the RNA sequences youll use in prime editing. We recently updated our blog post on Prime Editing , and that meant rereading many of the original papers reporting various prime editing tools.

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RNA Molecular Biology 97

Codon

MAY 8, 2025

Do you like molecular biology? In attempting that, I will lead you through a frantic tour of information theory and molecular biology. On biology At some point, your high-school biology teacher probably told you (or will tell you) this story about how life works: First, your DNA gets transcribed into matching RNA.

DNA 77

DNA RNA Molecular Biology Regulations 77

Broad Institute

JANUARY 7, 2025

From her first biology course in high school, Rehm loved the logic of genetics: the clear trajectory from a simple code of DNA to RNA to proteins and how disrupting that process could lead to disease.

Disease 121

Disease Science Laboratories Medical Schools 121

Codon

MAY 29, 2025

This deadly structure allows it to kill its victims by preventing their cells from making messenger RNA (mRNA) through inhibition of the enzyme RNA Polymerase II. The ADC approach allows healthy cells to avoid the deadly effects suffered by the cancer cells as their RNA polymerase II enzymes are shut down.

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Drugs DNA RNA Laboratories 106