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Researchers map how the brain regulates emotions

Science Daily: Pharmacology News

A new study is among the first of its kind to separate activity relating to emotion generation from emotion regulation in the human brain. The findings provide new insights that could help inform therapeutic treatments regarding mental health and drug addiction.

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An astrocytic pH regulator that can repair the blood-brain barrier and reverse brain damage caused by ischemic stroke

Science Daily: Pharmacology News

A recent study has found that an ion transporter protein that regulates the pH of specific brain cells can repair the blood-brain barrier and restore normal brain function after ischemic stroke.

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Regulator and Funder? FDA’s Orphan Products Grants Program awards significant funding to help move promising treatments through clinical development

FDA Law Blog: Drug Discovery

Food and Drug Administration (FDA) plays a pivotal role in fostering the development of treatments for rare diseases through its Orphan Products Grants Program. The Natural History Studies Grants Program funds natural history studies that collect gather data on how rare diseases progress over time without treatment.

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Ferulic Acid Inhibits Partial Epithelial‐Mesenchymal Transition in Renal Tubular Epithelial Cells and Mitigates Renal Interstitial Fibrosis by Regulating the HIF‐1α/Twist Signaling Pathway

Chemical Biology and Drug Design

The overall mechanism diagram of ferulic acid delaying renal interstitial fibrosis and inhibiting incomplete EMT of TECs by regulating HIF-1α. Combining siTwist or oe-HIF-1α transfection with FA treatment revealed that FA targeted the HIF-1α/Twist signaling pathway, impeding EMT and delaying renal fibrosis.

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FDA sets decision dates for Vertex, CRISPR gene editing drug

BioPharma Drive: Drug Pricing

The regulator will issue separate verdicts on the pioneering treatment’s use in sickle cell disease and beta thalassemia, with the first expected late this year.

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Tau-regulating protein identified as a promising target for developing Alzheimer's disease treatment

Science Daily: Pharmacology News

A gene encoding a protein linked to tau production -- tripartite motif protein 11 (TRIM11) -- was found to suppress deterioration in small animal models of neurodegenerative diseases similar to Alzheimer's disease (AD), while improving cognitive and motor abilities, according to new research.

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Exploration of the Active Components and Mechanism of Jiegeng (Platycodonis Radix) in the Treatment of Influenza Virus Pneumonia Through Network Pharmacology Analysis and Experimental Verification

Chemical Biology and Drug Design

Combined with network pharmacology and experimental verification, this study found that platycodin D and luteolin in Jiegeng ( Platycodonis Radix ) may regulate inflammation through the IL-17 signaling pathway to treat influenza virus pneumonia.

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