Drugs.com

JUNE 7, 2023

MONDAY, June 5, 2023 -- It’s tempting to treat little skin bumps on your own, but that delays proper diagnosis and treatment that may work better, federal regulators cautioned. Among the many types of skin conditions a person can contract are.

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Covalent Modifiers

MAY 9, 2024

Hopkins Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.4c00220 4c00220 Multiple sclerosis (MS) is a chronic disease with an underlying pathology characterized by inflammation-driven neuronal loss, axonal injury, and demyelination.

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Treatment Clinical Development Disease Regulations 208

Drug Target Review

MARCH 17, 2025

Neuropsychiatric treatment is on the verge of a major transformation. Neuropsychiatric disorders, affecting millions worldwide, disrupt the brain’s intricate processes of mood regulation, cognition and behaviour. “Zelquistinel is a positive modulator of NMDA receptors,” Donello explains.

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Treatment Licensing Licensing Science 52

Chemical Biology and Drug Design

JULY 13, 2023

Coptisine inhibits the malignancy of BC cells via regulating XPO1. This study showed that COP treatment markedly suppressed the malignant biological behaviors of bladder carcinoma cells. COP treatment modulated the expression level of cyclin D1 and CYP450 via XPO1.

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Drug Target Review

NOVEMBER 25, 2024

As the CEO of iOnctura, an innovative oncology biopharmaceutical company she co-founded in 2017, Catherine has played a key role in advancing the development of highly targeted small molecules aimed at revolutionising cancer treatment. This is exciting because often resistance builds up to these other treatments.

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Treatment Small Molecule Clinical Trials Trials 52

Chemical Biology and Drug Design

SEPTEMBER 30, 2023

Abstract Epigenetic regulation of genes through posttranslational regulation of proteins is a well-explored approach for disease treatment, particularly in cancer chemotherapy. Structural classification and regulatory functions of histone deacetylases and their inhibitors.

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Chemical Biology and Drug Design

NOVEMBER 1, 2023

Kaempferol exerted antioxidant effects in AR-DOR by inhibiting Hsp90 to up-regulate Nrf2. In this study, 36 volunteers and 78 DOR patients (37 patients with EXD treatment) were enrolled in the clinical research. In summary, kaempferol exerts an antioxidant effect on AR-DOR by inhibiting HSP90 expression to up-regulate NRF2 expression.

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SCIENMAG: Medicine & Health

NOVEMBER 27, 2023

An innovative stem cell-based treatment for Type 1 diabetes can meaningfully regulate blood glucose levels and reduce dependence on daily insulin injections, according to new clinical trial results from the University of British Columbia (UBC) and Vancouver Coastal Health (VCH).

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Drug Target Review

DECEMBER 20, 2024

These twins simulate how a patients condition might evolve without treatment, enabling researchers to compare the real-world effects of an experimental therapy against predicted outcomes. Regulators care a lot about controlling the Type 1 error rate of the clinical trial, Smith notes.

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Chemical Biology and Drug Design

JANUARY 24, 2024

A new herbal formula, YH complex, might be an effective treatment for androgenetic alopecia. From result of network analysis, the possible underlying mechanism of YH complex was closely related with the “regulation of hair cycle” and “apoptosis signaling pathway.” In depilated AGA mice, YH complex markedly promoted hair regrowth.

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Chemical Biology and Drug Design

SEPTEMBER 24, 2023

This finding provides new ideas for the development of drug targets for the treatment of ischemic stroke. This research is powered to probe whether the molecular mechanism of JAS for IS treatment is coupled with microglia polarization. JAS reduces IS injury by regulating microglia polarization via PASK-EEF1A1 axis.

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biobide

AUGUST 18, 2023

Cruelty-free cosmetics have emerged as a powerful statement within the beauty industry and Fast Moving Consumer Goods (FMCG), reflecting a growing consumer consciousness on the ethical treatment of animals. In 2004 the European Union (EU) introduced a ban on animal testing on finished products.

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Regulations Animal Testing Production Treatment 92

Advarra

JULY 26, 2022

Importantly, the 2018 Farm Bill preserved FDA authority to regulate products with cannabis or cannabis-derived compounds under the Federal Food, Drug, and Cosmetic (FD&C) Act and Section 351 of the Public Health Service Act. The post CBD Research: A Dive into the Regulations of Cannabis Research appeared first on Advarra.

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Chemical Biology and Drug Design

MARCH 8, 2024

Next, quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure the expression levels of Glial fibrillary acidic protein (GFAP), C3, S100 calcium binding protein A10 (S100a10), pentraxin 3 (Ptx3), toll-like receptor 4 (TLR4), and RAG in astrocytes after different treatments.

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Chemical Biology and Drug Design

JANUARY 24, 2024

Baicalin alleviates OGD/R-induced SK-N-SH cell apoptosis, inflammation, and ferroptosis in vitro, and brain injury in MCAO mice in vivo, via the regulation of miR-556-3p/ACSL4 pathway. Our study showed that BCL treatment alleviated OGD/R-induced SK-N-SH cell apoptosis, inflammation and ferroptosis.

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Drug Target Review

APRIL 7, 2025

For example, transcriptomic processes are showing the potential to identify and track failures in gene expression and gene regulation of amyloid and tau-related biomarkers, understood as precursors to the onset of Alzheimers disease (AD). A biomarker is a measurable indicator of a biological process, disease state, or response to a treatment.

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Clinical Development Clinical Trials Clinical Pharmacology Trials 69

Chemical Biology and Drug Design

JANUARY 23, 2024

Matrine inhibits the growth and metastasis of hepatocellular carcinoma by regulating the ELAVL1/RBM3-mediated Wnt/β-catenin signaling pathway. Moreover, ELAVL1 might bind with RBM3 to positively regulate the stability of RBM3 mRNA. Nevertheless, the anti-tumor molecular mechanism of Martine in HCC is still not fully revealed.

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Chemical Biology and Drug Design

SEPTEMBER 6, 2023

Matrine inhibits TNBC cell proliferation, migration and invasion, promotes apoptosis, and suppresses tumor growth through down-regulation of HN1 expression. Abstract The treatment of triple-negative breast cancer (TNBC) cannot meet medical needs, and it is urgent to find new drugs for intervention.

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Chemical Biology and Drug Design

MARCH 8, 2024

Circ_0139658 is directly bound to miR-653-5p to regulate YY1 expression. Brucine treatment suppressed circ_0139658 and YY1 expression but increased YY1 expression in RA-FLSs. RA-FLSs showed increased circ_0139658 and YY1 levels and decreased miR-653-5p levels.

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Chemical Biology and Drug Design

JANUARY 4, 2024

Furthermore, AS-IV performed a beneficial anti-cancer effect by regulating the circ_0001615/miR-873-5p/LASP1 network in the CRC. According to the IC50 of AS-IV in CRC cells, the 100 ng/mL AS-IV treatment for 24 h was chosen for the following research: Our data confirmed that AS-IV is a beneficial anti-cancer agent in CRC cells.

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Chemical Biology and Drug Design

OCTOBER 4, 2023

After a series of data analyses and experimental verification, we found formononetin may inhibit hepatocyte metabolism and cell cycle regulation-related pathways by modulating ESR1 , CCNA2 , and CHEK1 , thereby inhibiting HepG2 cell proliferation. This study provides insights into potential HCC treatments.

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DrugBank

JULY 8, 2024

Revolutionizing Treatment Through the Skin with Transdermal Drug Delivery Systems The human skin, often perceived as a passive barrier to the external environment, holds potential as a route for drug administration. This membrane regulates the diffusion of the drug from the reservoir into the skin.

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ASPET

SEPTEMBER 16, 2024

GBM has a poor prognosis despite aggressive treatment, in part due to lack of adequate drug permeability at the BBB. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemo-sensitizers.

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Drugs.com

OCTOBER 11, 2024

11, 2024 -- Hucksters offering bogus stem cell treatments can be deterred through government action, a new study says.About 60% of direct-to-consumer advertising from fly-by-night stem cell clinics ceased after regulators in Canada and. FRIDAY, Oct.

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Covalent Modifiers

MAY 15, 2023

Chan, Gui Lu European Journal of Medicinal Chemistry , 2023 [link] Aurora kinases, which belong to the serine/threonine protein family, play critical roles in the regulation of the cell cycle and mitotic spindle assembly. Despite the development of some reversible Aurora kinase inhibitors, none has been approved for clinical use yet.

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BioPharma Drive: Drug Pricing

AUGUST 17, 2023

The mixed results supporting the treatment, Sohonos, have proven a tough case for regulators and led to different outcomes in the U.S. and Europe.

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Chemical Biology and Drug Design

JULY 4, 2023

Acacetin may be a promising drug in complementary therapy of cancer treatment. Acacetin treatment induced bax's expression and repressed bcl-2's expression. Abstract Acacetin is a natural flavonoid compound found in diverse plants, which has strong anti-inflammatory and anti-cancer activities.

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ASPET

AUGUST 5, 2024

Long term treatment leads to increases in receptor abundance and activity with no changes in mRNA supporting a role as pharmacological chaperones. Overexpression of RTP4 causes an increase and knock-down causes a decrease in the levels of CB 1 R, DOR, and CB 1 R-DOR interacting complexes; this is accompanied by parallel changes in signaling.

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Chemical Biology and Drug Design

DECEMBER 18, 2023

The Buzhong Yiqi decoction regulated the PI3K-AKT signaling pathway in non-small cell lung cancer A549 cells. The Buzhong Yiqi decoction (BZYQD), traditional Chinese medicine (TCM) formula, has been reported to exhibit clinical efficacy in the treatment of NSCLC. Nevertheless, the underlying molecular mechanism remains elusive.

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Covalent Modifiers

DECEMBER 22, 2023

2023.11.008 The TRF2 shelterin component is an essential regulator of telomere homeostasis and genomic stability. We demonstrate that APOD53 impairs cancer cell growth and find that co-treatment with APOD53 can exacerbate telomere replication stress caused by the G4 stabilizer RHPS4 and low dose aphidicolin (APH).

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Chemical Biology and Drug Design

JULY 16, 2023

NAFLD mice model was established by HFD for 12 weeks, and LQ treatment for 1 week. HFD mice showed significant increases in hepatic TG and TC, and plasm TC, TG, and LDL-C in blood lipids, while HDL-C significantly decreased, and LQ treatment reversed their levels ( p  < 0.05).

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PPD

MARCH 11, 2025

Developing treatments for individuals living with rare diseases is critical, but orphan drug development is laden with unique obstacles that necessitate innovative, multifaceted approaches. This limited pool poses significant barriers to conducting statistically significant studies and validating the efficacy and safety of new treatments.

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SCIENMAG: Medicine & Health

AUGUST 16, 2023

Medications to treat various chronic diseases may hinder the body’s ability to lose heat and regulate its core temperature to optimal levels.

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Regulations Disease Treatment 60

Common Sense for Drug Policy Blog

OCTOBER 1, 2024

New regulations governing methadone treatment for opioid use disorder go into effect in the US on October 2, 2024. As reported by the Associated Press on Sept. 20, 2024 ("US will let more people take methadone at home"):

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Broad Institute

MAY 21, 2025

In one study , scientists successfully targeted and labeled a rare cell that regulates sleep, opening the door to new cell type-specific treatments for sleeping disorders. These materials will serve as a valuable, catalytic resource for the global scientific community working to find new treatments and therapies for brain disease.

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Disease Medical Schools DNA Therapies 72

Chemical Biology and Drug Design

JULY 27, 2023

Effects of circ_0002375 on cisplatin-resistant NPC cells: After cisplatin treatment, circ_0002375 knockdown was transfected into cisplatin-resistant SUNE1/5-8F cells, which led to the inhibition of cisplatin resistance via down-regulating EIF5A2 that mediated by up-regulated miR-577.

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Chemical Biology and Drug Design

SEPTEMBER 28, 2023

SEV regulated the migration, invasion, and angiogenesis of OSCC cells through the circ_0000857/miR-145-5p axis, which provided a basis for the potential role of SEV in the treatment of OSCC. This study investigated whether sevoflurane (SEV) inhibited OSCC cell progression by regulating circular RNA_0000857 (circ_0000857).

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