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Researchers map communities of single cells in metastatic breast cancers

Broad Institute

Researchers map communities of single cells in metastatic breast cancers By Corie Lok October 30, 2024 Breadcrumb Home Researchers map communities of single cells in metastatic breast cancers The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies.

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An ancient RNA-guided system could simplify delivery of gene editing therapies

Broad Institute

An ancient RNA-guided system could simplify delivery of gene editing therapies By Corie Lok February 27, 2025 Breadcrumb Home An ancient RNA-guided system could simplify delivery of gene editing therapies The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.

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Scientists just resurrected the 1918 “Spanish Flu” virus—here’s what they found

Science Daily: Pharmacology News

This ancient RNA revealed that the virus had already adapted to humans at the very start of the pandemic, carrying mutations that made it both more infectious and more immune-resistant. By pioneering a new method to recover fragile RNA from preserved tissue, researchers gained rare insights into how flu viruses evolve.

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Novartis Acquires Regulus Therapeutics, Expanding its RNA-Based Drug Pipeline

The Pharma Data

The move also reinforces a broader trend within the pharmaceutical industry: the growing interest in RNA-based therapeutics , including oligonucleotides and microRNA modulators. These modalities offer a new layer of precision in targeting diseases that are difficult to address with conventional small molecules or biologics.

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Scientists apply optical pooled CRISPR screening to identify potential new Ebola drug targets

Broad Institute

Now, researchers at the Broad Institute and the National Emerging Infectious Diseases Laboratories (NEIDL) at Boston University have used an image-based screening method developed at the Broad to identify human genes that, when silenced, impair the Ebola virus’s ability to infect. By Leah Eisenstadt July 24, 2025 Credit: CDC/ Frederick A.

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NGS is evolving: collaboration and tech lead the way

Drug Target Review

Research by Markets and Markets projects the market to grow from $12.13 1 Emergen Research attributes this to the advantages of high-throughput sequencing technologies and declining sequencing costs​. 2 This trend reflects the increasing demand for genomic sequencing in research, clinical diagnostics and other applications.

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The sugar that sparked life: Why ribose was RNA’s first choice

Science Daily: Pharmacology News

Scientists at Scripps Research may have cracked a major part of this mystery. Their experiments show that ribose binds more readily and selectively to phosphate compared to other similar sugars, forming a structure ideal for RNA formation. What made ribose the sugar of choice for life's code?

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