The Pharma Data

OCTOBER 19, 2020

related to a completed Phase 1 clinical trial with Berubicin in malignant brain tumors, which Reata conducted in 2006. Its second drug candidate, WP1244, is a novel DNA binding agent that has shown in preclinical studies that it is 500 times more potent than the chemotherapeutic agent daunorubicin in inhibiting tumor cell proliferation.

Clinical Trials 52

Clinical Trials Trials Pharmaceuticals Treatment 52

The Pharma Data

DECEMBER 16, 2020

related to a completed Phase 1 clinical trial with Berubicin in malignant brain tumors, which Reata conducted in 2006. Its second drug candidate, WP1244, is a novel DNA binding agent that has shown in preclinical studies that it is 500 times more potent than the chemotherapeutic agent daunorubicin in inhibiting tumor cell proliferation.

FDA Approval 52

FDA Approval FDA Pharmaceuticals Clinical Trials 52

New Drug Approvals

JANUARY 9, 2024

CDK7 also plays a role in transcription and possibly in DNA repair. The trimeric Cak complex CDK7/CyclinH/MATl is also a component of TFIIH, the general transcription/DNA repair factor IIH (Morgan, DO., 2006 Mar 1; 20(5):601-12, 2006), in contrast with CDK9, which phosphorylates both Ser-2 and Ser-5 of the CTD heptad (Pinhero et al.,

Production 62

Production DNA RNA Regulations 62

Codon

APRIL 23, 2024

While astronauts are easily protected from UV by glass or a thin sheet of metal, microbes placed outside on Mars would be killed in mere minutes as the ultraviolet radiation shreds through DNA and destabilizes proteins that carry out important cellular processes. A 58-page NASA report from 2006 arrived at a similar conclusion.

Engineering 106

Engineering DNA Hospitals International 106

Drug Target Review

JANUARY 24, 2024

For the first time, researchers have identified short strands of toxic RNAs that contribute to brain cell death and DNA damage in Alzheimer’s and aged brains, and that during ageing, short strands of protective RNAs decrease. 2006 July 29 [2024 January 18]; 368(9533):387-403. 2006 July 29 [2024 January 18]; 368(9533):387-403.

RNA 64

RNA Disease DNA Engineering 64

PLOS: DNA Science

JUNE 22, 2023

A “DNA damage checkpoint” rests the cell cycle while special proteins repair damaged DNA. I had the privilege to meet one of the first people to receive Gleevec, which I wrote about for Bioethics Today in 2006. She sent me a photo of her grimacing while having a bone marrow aspiration for my textbook back in 2006.

Drugs 52

Drugs Small Molecule DNA Bioethics 52

The Pharma Data

FEBRUARY 22, 2022

He is co-founder and non-executive board member of the Hartwig Medical Foundation (large scale DNA analyses) and is a board member of the Center for Personalized Cancer Treatment and leads several innovative precision oncology clinical trials. He has founded and leads several innovative precision medicine initiatives in oncology.

Clinical Trials 52

Clinical Trials DNA Science Clinical Development 52

BMG Labtech

MARCH 8, 2023

DNA, proteins, polysaccharides, etc.). They are strongly oxidizing and, at high concentrations, are deleterious to cells damaging DNA, proteins and lipids, and eventually leading to cell death. Dimroth P, 2006, Catalytic and mechanical cycles in F-ATP synthases. nucleotides, monosaccharides, etc.), New York: W. 7 (3): 276–82.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 109

DNA Laboratories Hospitals Virus 109

Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. DNA damaging agent-based antibody-drug conjugates for cancer therapy. 12 , 2955–2960 (2006). 4 But the horizon of ADCs is expanding even further, with the design of complex payloads. Florian S, Mitchison TJ.

Small Molecule 126

Small Molecule Drugs Immune Response Targeted Protein Degradation 126

PLOS: DNA Science

MARCH 30, 2023

GISAID began in 2006 in response to bird flu, becoming a global clearinghouse for data and maps galore on epidemic and pandemic viruses. Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA). Imagine if we could have done that with COVID!

DNA 52

DNA Hospitals Laboratories Virus 52

Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. But today, rapid advances in DNA synthesis have made it possible for would-be bioterrorists to make pathogens, rather than buy them. Credit: Alamy In a 2006 report , the U.S. This article concludes our mini-issue. Thanks for reading!

DNA 103

DNA Bioinformatics Virus Government 103

Drug Target Review

DECEMBER 12, 2024

In 2006, scientists Kazutoshi Takahashi and Shinya Yamanaka demonstrated stem-cell differentiation could be reversed. Enter epigenetics Broadly speaking, epigenetics refers to the system of proteins and marks that sits atop our genome a system that modifies gene expression, guides cell differentiation, and functionally organises our DNA.

Therapies 59

Therapies DNA Molecular Biology Immune Response 59

PLOS: DNA Science

MARCH 13, 2025

The biobank has been amassing data since 2006. The post Study Identifies 7 Genes Associated with Brain Aging and 13 Drugs that May Help Extend the Healthspan appeared first on DNA Science. The study used information from nearly 39,000 participants. A similar effort in the US is All of Us , which I hope survives the gutting of the NIH.

Drugs 65

Drugs Science Disease Clinical Trials 65

Agency IQ

MARCH 29, 2024

EPA then conducted a residual risk and technology review on July 27, 2006 (71 FR 42724). EPA completed a residual risk and technology review for the NESHAP in 2006 and, at that time, concluded that no revisions to the standards were necessary. The NESHAP established standards for both major and area sources. section 7412(d)(6).

Regulations 40

Regulations Compliance Production Government 40

Drug Target Review

DECEMBER 16, 2024

Growing up with a scientist mother and a builder father likely influenced my inclinations it seems to be part of my DNA. She has been integral to the research and development of all Waters Corporations single and tandem quadrupole instruments since 2006 and has led the development projects for several successful instruments.

Engineering 52

Engineering Science Production DNA 52

Codon

MAY 15, 2025

In 2006, researchers at the University of Alberta tried to replicate a 1993 mouse study. Random mutations in DNA bring about this genetic variation, and mating between unrelated individuals mixes the mutations amongst the population. percent of the mouse’s DNA. Credit: Wahlsten D. Genetics are partly to blame.

DNA 75

DNA Laboratories RNA Regulations 75

Codon

MAY 22, 2025

In 2006 , a landmark study by biochemist Gerry Wright and colleagues at McMaster University showed that nearly 500 randomly isolated soil-dwelling Streptomyces were, on average, resistant to 7 or 8 antibiotics. DNA is particularly durable, with a half-life measured in thousands of years — far outlasting bacterial cells.

DNA 97

DNA Laboratories Doctors Production 97

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

FEBRUARY 9, 2025

In 2006, The Howard Hughes Medical Institute's Janelia Research Campus initiated FlyEM , a project aiming to reconstruct the complete connectome of the Drosophila brain using state-of-the-art EM and computational tools.

Research 112

Research Disease Engineering Regulations 112

Codon

FEBRUARY 23, 2025

Researcher Jerome Horwitz at the Michigan Cancer Foundation developed it as a potential cancer treatment by chemically-modifying thymine, a DNA building block. Since zidovudine failed to interfere with DNA-to-DNA replication, Ostertag wondered if it could block RNA-to-DNA replication instead.

Clinical Trials 76

Clinical Trials Virus Vaccine Trials 76