Drugs.com

JULY 18, 2024

THURSDAY, July 18, 2024 -- Alix Popham played in two rugby World Cups and won a Six Nations Grand Slam before retiring in 2011 as a professional in the rough-and-tumble game. By 2020, he had already been diagnosed with early onset dementia and.

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Covalent Modifiers

FEBRUARY 6, 2024

However, there has been a resurgence in covalent drug design following the success of several covalent drugs such as boceprevir (2011), ibrutinib (2013), neratinib (2017), dacomitinib (2018), zanubrutinib (2019), and many others.

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Drugs Research 182

NIOSH Science Blog: Drugs

APRIL 10, 2024

From 2011 to 2022, there were 1,462 fatal occupational injuries that occurred at road construction sites.[1] Struck-by injuries are the leading cause of nonfatal injuries and second most common cause of fatalities among construction workers.

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International 113

SCIENMAG: Medicine & Health

OCTOBER 31, 2023

AMES, Iowa – Since 2011, roughly 10,000 people in the U.S. Credit: Photo by Ryan Riley/Iowa State University AMES, Iowa – Since 2011, roughly […] have turned 65 every day. The Baby Boomer generation and those born before 1946 make up the country’s fastest growing age group, which is on track to outnumber children by 2035.

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Perficient: Drug Development

MAY 15, 2025

GAAD was founded in 2011 with the goal of sparking conversations about digital accessibility. Held every third Thursday in May, GAAD encourages individuals, businesses, and organizations to reflect on the importance of creating accessible digital experiences. What is GAAD?

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Production 52

Antidote

JANUARY 29, 2024

Jamie received a diagnosis of stage IV melanoma in 2011, only 11 weeks after giving birth to her child. Not only will patients be able to gain access to potential new treatments, but they will also be directly contributing to research that can save lives — something that Jamie Troil Goldfarb has experienced firsthand.

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Clinical Trials Trials Doctors Treatment 122

Drug Patent Watch

DECEMBER 30, 2024

Pharmaceutical Regulations in Japan 2020. Retrieved from [link] Pharmaceuticals and Medical Devices Agency. Regulatory System on Generic Drugs in Japan. Retrieved from [link] Raflzadeh-Kabe, J. Japanese Pharmaceutical and Regulatory Environment. Journal of Clinical Pharmacology , 51(3), 531538.

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SCIENMAG: Medicine & Health

JANUARY 24, 2024

The Fukushima Daiichi nuclear disaster, triggered by the earthquake and tsunami on March 11, 2011, resulted in a severe release of radioactive materials, including cesium, from the damaged nuclear reactors.

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Sygnature Discovery

FEBRUARY 12, 2025

Since 2011, Sygnature Discovery has delivered 50 novel pre-clinical and 30 clinical compounds, with its scientists named on over 170 patents. Additional sites are located in Alderley Park, Macclesfield, and Glasgow (UK), as well as Montreal and Quebec City (Canada).

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SCIENMAG: Medicine & Health

JULY 5, 2023

But a study published by The BMJ today finds that less than half of approved first indications for new drugs in the US and Europe between 2011 and 2020 add substantial therapeutic value over existing treatments […]

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Treatment Drugs Disease 67

Perficient: Drug Development

AUGUST 31, 2023

Kotlin is a programming language introduced by JetBrains in 2011. Our Kotlin tutorial includes. What is Kotlin? Pre-Requisites Features of Kotlin Kotlin Architecture What is Kotlin? Kotlin is free, has been free and will remain free. It is developed under the Apache 2.0 Google announced Kotlin is an official language for android development.

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The Pharma Data

DECEMBER 7, 2020

older adults who reported owning and using hearing aids increased from 2011 to 2018, according to a research letter published online Dec. percent in 2011, 2015, and 2018, respectively. MONDAY, Dec. 7, 2020 — The proportion of U.S. 7 in JAMA Internal Medicine. Nicholas S. Reed, Au.D., percent).

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International Research 52

Agency IQ

APRIL 12, 2024

BY RACHEL COE, MSC Late last year, the FDA published a draft update to its 2011 guidance on potency assays for cell and gene therapy products, unveiling a major shift in approach to the issue. Now, the deadline for feedback to that draft guidance has passed, and AgencyIQ has an analysis of the comments here.

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Production Laboratories FDA Regulations 59

Common Sense for Drug Policy Blog

DECEMBER 12, 2023

Total Adult Community Supervision Population in the US "From yearend 2011 to yearend 2021, the total adult community supervision population fell 22%, from 4,818,300 to 3,745,000 (table 1). Between 2011 and 2019, the U.S. Most of this decrease was due to a decline of 25% (1 million) in the number of adults on probation.

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Broad Institute

MARCH 8, 2024

Hung (2010 - 2011 awardee) James Bradner Jake Jaffe 2011 - 2012 Awardees Feng Zhang John Rinn Mitchell Guttman Anne Carpenter 2010 - 2011 Awardees Deborah T. Any questions about the Next Generation Awards program can be directed to Jacob Herman at jherman@broadinstitute.org. Hung Bradley Bernstein Tarjei Mikkelsen

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Research 52

SCIENMAG: Medicine & Health

OCTOBER 11, 2023

However, the Great Atlantic Sargassum Belt (GASB) that emerged in 2011 has since then caused unprecedented inundations of this brown seaweed on Caribbean coastlines, with harmful effects on ecosystems while posing challenges […] 11, 2023) — Under normal conditions, the floating macroalgae Sargassum spp.

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SCIENMAG: Medicine & Health

SEPTEMBER 27, 2023

Credit: Copyright © 2011 Michael Bonert […] Over time, accumulating scarring distorts the liver, interferes with its blood supply and may progressively lead to worsening consequences, from cirrhosis to liver failure to liver cancer. In advanced cases, the only treatment is an organ transplant.

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Treatment 52

FDA Law Blog: Biosimilars

AUGUST 12, 2024

Patent and Trademark Office consulted with FDA on the appropriate timelines, FDA claimed that the INAD, and thereby the testing phase, was not effective until August 4, 2011 because no NCIE was submitted until then. Thus, the Agency concluded, the June 2011 date should stand. On August 8, 2024, the Court granted Nissan et al.’s

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New Drug Approvals

NOVEMBER 13, 2023

amcrasto@amcrasto /////////// Ref [1]. amcrasto@amcrasto /////////// Ref [1].

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Treatment Disease Therapies Production 64

Broad Institute

MARCH 14, 2024

In the new study, the researchers used a system called phage-assisted continuous evolution (PACE), first developed in Liu’s lab at Harvard in 2011, to generate a degron that might work with PT-179. PACE allows researchers to rapidly evolve new proteins that have useful features.

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Targeted Protein Degradation Small Molecule Medical Schools Science 141

Drug Target Review

FEBRUARY 12, 2024

In 2007, I was involved in a ‘management buy-in’, before selling the company to Ipca Laboratories in 2011. I became a Director in 2005, responsible for the business’s continued growth from 7 initial founding members to 110 employees today.

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New Drug Approvals

SEPTEMBER 8, 2024

September 2011). “MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin” The Journal of Clinical Endocrinology and Metabolism. . ^ Bays HE, Schwartz S, Littlejohn T, Kerzner B, Krauss RM, Karpf DB, et al.

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Drug Target Review

NOVEMBER 1, 2023

2011 Jul 14;54(13):4619–26. Molecular Neurobiology. 2020 Jan 1;57(1):372–92. Albers HMHG, Hendrickx LJD, van Tol RJP, et al. Structure-Based Design of Novel Boronic Acid-Based Inhibitors of Autotaxin. Journal of Medicinal Chemistry. Keune WJ, Potjewyd F, Heidebrecht T, et al. J Med Chem. 2017 Mar 9;60(5):2006–17.

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Clinical Trials Trials Small Molecule Disease 134

FDA Law Blog: Biosimilars

MAY 27, 2024

Jennifer was with the firm from 2011-2017, before leaving for in-house roles at Apple, Abbott Laboratories, and Cognito Therapeutics. “Jennifer’s return adds depth and breadth to our device practice and her strong relationships from her earlier time at the firm has made for a seamless reentry,” said J.P. Ellison, Managing Director at HPM.

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Laboratories Compliance FDA Regulations 59

Broad Institute

AUGUST 31, 2023

To optimize the reverse transcriptase domain of prime editors in a more directed way, Liu’s group turned to PACE (phage-assisted continuous evolution), a directed evolution approach developed by Liu in 2011. Only those expressing gene variants with specified desirable traits can survive by replicating faster than they are diluted.

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Drug Target Review

DECEMBER 1, 2023

2011 February 1 [2023 November 15]; 20(1):5-14. He concluded: “This breakthrough, driven by our commitment to advancing scientific frontiers, heralds a milestone in the realm of cellular studies.” This study was published in Lab on a Chip. Reference 1 Ding DC, Lin SZ, Shyu WC. Mesenchymal Stem Cells. Cell Transplantation.

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The Pharma Data

NOVEMBER 17, 2020

31, 2011, to examine the impact of antibiotic exposure in the first two years of life. Zaira Aversa, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues conducted a population-based cohort study involving children born in Olmsted County, Minnesota, between Jan. 1, 2003, and Dec.

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Therapies Doctors Disease Research 52

Drug Target Review

NOVEMBER 27, 2023

a biopharmaceutical company, from August 2007 until its acquisition by Roche Holding AG in 2011. Previously, Dr Worland served as Chief Executive Officer of Anadys Pharmaceuticals, Inc., Prior to Anadys Pharmaceuticals, Inc., Dr Worland was Vice President and Head of Antiviral Research at Pfizer Inc. and Vice President at WarnerLambert Co.,

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Molecular Biology Therapies Pharmaceuticals Treatment 86

The Pharma Data

JANUARY 12, 2021

The researchers found a significant decrease in the prevalence of albuminuria from 1988-1994 to 2011-2018 (38.9 Trends in albuminuria, reduced estimated glomerular filtration rate (eGFR), retinopathy, and self-reported cardiovascular disease were estimated.

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Disease Research 52

The Pharma Data

MARCH 23, 2021

In the interview, Mr. Reinhardt was asked about the company’s $678 million settlement last year with the United States Government, which resolved claims that during the time period from 2002 to 2011, Novartis used certain promotional programs as a way improperly to induce doctors to prescribe Novartis products, in violation of US anti-kickback law.

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Doctors Government Production 52

The Pharma Data

JANUARY 5, 2021

Renal Data System to the electronic health records of a large dialysis provider to identify 45,591 adult patients with Medicare Parts A and B who initiated dialysis (2006 to 2011) without previously recognized PAD. Associations between IDH and newly diagnosed PAD were evaluated.

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Disease Pharmaceuticals Research 52

The Pharma Data

JANUARY 4, 2021

from Texas Children’s Hospital and Baylor College of Medicine in Houston, and colleagues conducted a comparative cross-sectional study using electronic health records from a tertiary care hospital between 2011 and 2016 to characterize anxiety, depression, and ADHD among youth with versus without CHD. Gonzalez, M.D.,

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Disease Hospitals Treatment Research 52

The Pharma Data

DECEMBER 14, 2020

Patient postoperative 30-day mortality was examined for surgeries performed on surgeons’ birthdays versus other days of the year among patients undergoing one of 17 common emergency surgical procedures in 2011 to 2014. Data were analyzed for 980,876 procedures performed by 47,489 surgeons. The researchers found that 0.2

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Hospitals Pharmaceuticals Research 52

The Pharma Data

NOVEMBER 30, 2020

Medicaid and uninsured patients aged 40 to 64 years were compared preexpansion (2011 to 2012) and postexpansion (2015 to 2016). Hoehn, M.D., Patients in nonexpansion states were compared to those in expansion states in January 2014. miles), and treatment at integrated network programs (DID, 2.67).

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Treatment Research 52

The Pharma Data

OCTOBER 29, 2020

Wiggs, from Indiana University in Bloomington, and colleagues used Swedish-registry data to examine the risks for ASD and ADHD in 14,614 children born from 1996 to 2011 to women with epilepsy.

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Doctors Pharmaceuticals Research Drugs 52

NIH Director's Blog: Drug Development

SEPTEMBER 20, 2018

While researchers had solved the structure of a GPCR bound to another class of G proteins, known as stimulatory G proteins (G s ) in 2011[3], the image you see above represents the first such glimpse of a GPCR bound to any G i protein. 2011 Jul 19;477(7366):549-55.

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Laboratories Research Regulations Drugs 52

Broad Institute

FEBRUARY 15, 2024

Garber began serving as interim president of Harvard University on January 2, 2024, after having served as the provost and chief academic officer since 2011. Alan Garber By Rose Circeo February 15, 2024 Alan Garber Interim President, Harvard University Alan M.

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Medical Schools Science Government International 52