2016 - Drug Discovery Digest

Pfizer quits Duchenne gene therapy, lays off staff following study setback

BioPharma Drive: Drug Pricing

JULY 30, 2024

The company is letting go of 150 staffers alongside a decision to officially terminate the high-profile program, which was acquired in 2016.

Therapies

David Liu receives Breakthrough Prize in Life Sciences

Broad Institute

APRIL 5, 2025

Base editing, which Lius team developed in 2016, is a gene editing technique that directly converts an individual DNA base pair into a different base pair. In 2016, he became a core institute member at the Broad Institute. Base editing was recently used to achieve the first-ever correction of a disease-causing mutation in patients.

Science

Science Clinical Trials DNA Disease

Cases of Drug-Resistant Gonorrhea Have Tripled in China, Posing a Global Threat

Drugs.com

MARCH 28, 2024

THURSDAY, March 28, 2024 -- A strain of highly antibiotic-resistant gonorrhea first emerged in China in 2016, and cases of this tough-to-treat infection have tripled there in just five years, Chinese researchers report. It's a warning to the rest.

Drugs

Drugs Research

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

MORE WEBINARS

In Mississippi, a Huge Jump in Cases of Babies Born With Syphilis

Drugs.com

SEPTEMBER 21, 2023

21, 2023 -- The United States is experiencing an alarming wave of congenital syphilis, and one southern state saw a 1,000% rise in babies born with the infection between 2016 and 2022. THURSDAY, Sept. The number of babies born with the infection in.

This Flu Season Is Worst In A Decade

Drugs.com

FEBRUARY 21, 2025

far, there have been at least 29 million illnesses and 370,000 hospitalizations related to the flu -- the most since the 2015-2016 season, according to the. FRIDAY, Feb. 21, 2025 -- The current flu season is shaping up to be the worst in a decade.So

Hospitals

U.S. Gender-Affirming Surgeries Nearly Tripled in 3 Years

Drugs.com

AUGUST 23, 2023

23, 2023 -- The number of Americans undergoing gender-affirming surgery is on the rise, new research reveals, almost tripling between 2016 and 2019 alone. WEDNESDAY, Aug. During that period, more than 48,000 patients -- about half of them between 19.

Research

You're Far Less Likely to Get an Opioid Now After Surgery

Drugs.com

DECEMBER 11, 2023

doctors had already cut the amount of opioids they gave patients after surgery by 2022 to just a third of the amount given in 2016, new research shows.Much of the. MONDAY, Dec. 11, 2023 -- In response to the ongoing crisis of opioid misuse, U.S.

Doctors

Doctors Research

Mood Disorders Have Increased Among Kids, Teens

Drugs.com

APRIL 23, 2025

in 2016, researchers. WEDNESDAY, April 23, 2025 -- Depression and anxiety have been increasing steadily among children and teenagers in recent years, a new study says.More than 1 in 10 children (10.6%) suffered from anxiety in 2022, up from 7.1%

Research

US Cocaine Seizure Effectiveness Rate, 2016-2020

Common Sense for Drug Policy Blog

JULY 16, 2023

US Cocaine Seizure Effectiveness Rate, 2016-2020 " Methodology and Limitations "Seizure data are obtained from OFO administrative records and is considered reliable. Available Data and Discussion "Total seizures dropped to 19,000 kilograms in 2019, the lowest in the 2016-2020 period and down 35 percent from the 2016 to 2019 average.

Government

Government Production Drugs

Overcoming challenges in biosimilar analytical characterization

Drug Patent Watch

DECEMBER 9, 2024

2016, November 11). Overcoming Regulatory Hurdles in the Development of Biosimilars. link] KBDNA. 2024, May 17). Biosimilars: Navigating the Landscape for Future Therapeutics. link] Lawless, L. Overcoming Challenges in the Emerging Biosimilar Landscape. National Association of Managed Care Physicians. link] Kurki, P., 2021, November 2).

EXPRESSION OF CONCERN: The Truncated Human Telomeric Sequence Forms a Hybrid‐Type Intramolecular Mixed Parallel/antiparallel G‐quadruplex Structure in K+ Solution

Chemical Biology and Drug Design

DECEMBER 9, 2024

1 (2016): 122-128, [link]. This Expression of Concern is for the above article, published online on 12 February 2016, in Wiley Online Library ( [link] ), and has been issued by agreement between the journal Editor-in-Chief, Roberta Melander; and John Wiley & Sons Ltd.

Drugs

Possible adulticidal drugs for Onchocerca volvulus

Drug Target Review

SEPTEMBER 21, 2023

The findings supported the possibility put forward by Cotton et al (2016) concerning the chance of repurposing these drugs for adulticidal treatment. Possible adulticidal drugs- something to ponder on Cotton et al (2016) made an important discovery when they sequenced the entire genome of O. The research showed that exposing O.

Drugs

Drugs Treatment Disease Research

Most prolific drug patent challengers

Drug Patent Watch

JULY 26, 2021

This chart shows the generic pharmaceutical companies that had the most successful drug patent challenges from 2016 to 2021. Companies that successfully challenge patents on branded drugs are granted six…. The post Most prolific drug patent challengers appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceutical Companies

Pharmaceutical Companies Drugs Pharmaceuticals

Most prolific drug patent challengers

Drug Patent Watch

NOVEMBER 9, 2021

This chart shows the generic pharmaceutical companies that had the most successful drug patent challenges from 2016 to 2021. Companies that successfully challenge patents on branded drugs are granted six…. The post Most prolific drug patent challengers appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceutical Companies

Pharmaceutical Companies Drugs Pharmaceuticals

Antibody Validation for Flow Cytometry

addgene Blog

SEPTEMBER 10, 2024

Antibody validation is to confirm (or refute) that the antibody is selectively detecting the target-of-interest in your assay and sample-of-interest. The approaches available broadly map onto the five pillars of antibody validation (see: Uhlen et al.,

Auburn University hosts the 60th edition of the Renowned Computational Biophysics Workshop

SCIENMAG: Medicine & Health

AUGUST 18, 2023

For the first time since 2016, the southern USA was home to the “Hands-On Workshop on Computational Biophysics” with Auburn University, for the first […]

Science

Fitusiran

New Drug Approvals

APRIL 11, 2025

World Health Organization (2016). . ^ “Qfitlia approved as the first therapy in the US to treat hemophilia A or B with or without inhibitors” Sanofi (Press release). 28 March 2025. Retrieved 29 March 2025. hdl : 10665/331046. Further reading Srivastava A, Rangarajan S, Kavakli K, Klamroth R, Kenet G, Khoo L, et al.

Clinical Trials

Clinical Trials FDA FDA Approval Trials

TBD

Broad Institute

AUGUST 31, 2023

TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Why GoodRx—Not Amazon—May Be the True PBM Disrupter

Drug Channels

AUGUST 17, 2021

That’s about six times its 2016 figure. Below I summarize the latest financial results for GoodRx’s discount card business. We estimate that the company accounted for $4.1 billion in U.S. prescription revenues for 2021. GoodRx and its discount card competitors profit by incentivizing people to bypass their own insurance plans.

Pharmacy

Pharmacy Marketing Drugs

Why GoodRx—Not Amazon—May Be the True PBM Disrupter (rerun)

Drug Channels

DECEMBER 13, 2021

That’s about six times its 2016 figure. Below I summarize the latest financial results for GoodRx’s discount card business. We estimate that the company accounted for $4.1 billion in U.S. prescription revenues for 2021. GoodRx and its discount card competitors profit by incentivizing people to bypass their own insurance plans.

Pharmacy

Pharmacy Marketing Drugs

New molecular insights on medical cannabis

Drug Target Review

NOVEMBER 1, 2023

2016 Jun 23;59(12):5604–21. 2016 Sep;7(1):11248. Frontiers in Medicine. 2018 Jun 13;5. Castagna D, Budd DC, Macdonald SJF, et al. Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature: Miniperspective. J Med Chem. Gotoh M, Fujiwara Y, Yue J, et al. Biochemical Society Transactions. 2012 Feb 1;40(1):31–6.

Clinical Trials

Clinical Trials Trials Small Molecule Disease

Unemployment and underemployment significant drivers of suicide: Analysis

SCIENMAG: Medicine & Health

JULY 12, 2023

A study examining unemployment and underemployment figures and suicide rates in Australia has found both were significant drivers of suicide mortality between 2004-2016.

Research

#ScienceSaturday: March 2, 2024

KIF1A

MARCH 2, 2024

Wendy Chung discusses advances from the Simons Foundation Powering Autism Research for Knowledge (SPARK) Project, which enrolled 275,000 participants with and without autism, between 2016 and 2022. This has created a platform to learn about autism-associated genes, identify risk factors for subgroups, and better inform new interventions.

Laboratories

Laboratories Cell Biology Disease Research

Children in Chile saw 73% fewer TV ads for unhealthy foods and drinks following trailblazing marketing restrictions

SCIENMAG: Medicine & Health

JUNE 8, 2023

The country’s multi-phased regulations, which began in 2016, have led to a 73% drop in children’s exposure to TV ads for regulated foods and drinks (those […]

Marketing

Marketing Regulations Production Research

Primary care clinics that improved patient access, identified at-risk patients and expanded services experienced reductions in acute hospitalizations

SCIENMAG: Medicine & Health

JULY 25, 2023

Researchers identified CPC+ practice sites with the highest likelihood of achieving substantial reductions in Medicare acute hospitalization rates between 2016 and 2018, and referred to them as “Acute Hospitalization Rate (AHR) […]

Hospitals

Hospitals Research

Investigating the intratumoural microbiome in young-onset CRC patients

Drug Target Review

FEBRUARY 8, 2024

2016 February 7 [2024 January 6]; 22(5): 1736-44. World Journal of Gastrointestinal Oncology. 2021 August 15 [2024 January 6]; 13(8):856-66. Available from: [link] 5 Ballester V, Boardman L, Rashtak S. Clinical and molecular features of young-onset colorectal cancer. World Journal of Gastrointestinal Oncology. Available from: [link]

Disease

Disease Research Drugs

Therapeutic Oligos 2025 Keynote Speakers Announced

Elrig

MARCH 25, 2025

In 2016, he was appointed Junior Group Leader with the Swiss National Centre for Competence in Research (NCCR) in RNA & Disease, where he established the laboratory for Genomics Of LncRNAs in Disease (GOLD Lab).

RNA

RNA Bioinformatics Science Pharmacokinetics

Have You Missed Any FDA Data Submission Requirements? A Look at Substantial Changes and New Requirements

Cytel

JANUARY 3, 2024

1 The following December, a second version was released after public comments and, on December 16, 2014, the FDA stopped the clock, providing sponsors with a pivotal two-year window to adapt their methods of creating clinical dataset packages to comply with the FDA’s new required data standards for any study commencing after December 16, 2016.

FDA

FDA Packaging

Out-of-Pocket Costs Rising for Neurology Tests, Visits

The Pharma Data

DECEMBER 23, 2020

23 2020 — From 2001 to 2016, out-of-pocket costs of evaluation and management (E/M) services and common diagnostic tests increased for neurology patients, according to a study published online Dec. respectively, for an MRI in 2016. WEDNESDAY, Dec. 23 in Neurology. Data were included for 3,724,342 patients. percent, respectively).

Research

The rising impact of biomarkers in early clinical development

Drug Target Review

APRIL 7, 2025

Silver Spring (MD): Food and Drug Administration (US); 2016-. The parallel evolution of novel therapies, biomarker endpoints and regulatory evolution may signal a new paradigm for clinical drug development over the coming years. References FDA-NIH Biomarker Working Group. BEST (Biomarkers, EndpointS, and other Tools) Resource [Internet].

Clinical Development

Clinical Development Clinical Trials Clinical Pharmacology Trials

VODOBATINIB

New Drug Approvals

NOVEMBER 13, 2023

amcrasto@amcrasto /////////// Ref [1]. amcrasto@amcrasto /////////// Ref [1]. amcrasto@amcrasto /////////// Ref [1].

Treatment

Treatment Disease Therapies Production

As Testing Costs Rise, Neurology Patients May Skip Screening

The Pharma Data

DECEMBER 24, 2020

For example, the percentage of patients who had out-of-pocket payments for MRIs rose from 24% in 2001 to 70% in 2016. For an MRI in 2016, the median amount was $103, but it was as high as $875 for some patients. The number of patients enrolled in high-deductible plans rose from zero in 2001 to 11% in 2016, according to the study.

Research

Growth in New/Novel Psychoactive Substances

Common Sense for Drug Policy Blog

JUNE 17, 2024

Between 2016 and 2022, typically around 50 new psychoactive substances appeared on the market for the first time each year; this fell to 26 in 2023. In addition, around 400 previously reported new substances are detected on the market each year."

Marketing

Marketing Drugs

Large Language Models and Biological Foundation Models

Broad Institute

OCTOBER 11, 2024

Large Language Models and Biological Foundation Models By lcopelan@broadinstitute.org October 11, 2024 Large Language Models and Biological Foundation Models Syed Rizvi Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

Lightning Talks

Broad Institute

AUGUST 30, 2024

Lightning Talks By lcopelan@broadinstitute.org August 30, 2024 Lightning Talks MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

AUGUST 28, 2024

TBD By lcopelan@broadinstitute.org August 28, 2024 TBD Brian Cleary MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

TBD

Broad Institute

AUGUST 22, 2024

TBD By lcopelan@broadinstitute.org August 22, 2024 TBD Abraham Gihawi MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Microbiome

Broad Institute

AUGUST 8, 2024

Microbiome By lcopelan@broadinstitute.org August 8, 2024 Microbiome Victoria Pascal MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring (..)

Molecular dynamics

Broad Institute

AUGUST 8, 2024

Molecular dynamics By lcopelan@broadinstitute.org August 8, 2024 Molecular dynamics Ashkan Fakharzadeh Ghaan MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring (..)

Tensor factorization + single-cell rna-seq

Broad Institute

AUGUST 8, 2024

Tensor factorization + single-cell rna-seq By lcopelan@broadinstitute.org August 8, 2024 Tensor factorization + single-cell rna-seq Neriman Tokcan UMass Boston MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall (..)

RNA

Single-cell genomics + LLM or OT

Broad Institute

AUGUST 8, 2024

Single-cell genomics + LLM or OT By lcopelan@broadinstitute.org August 8, 2024 Single-cell genomics + LLM or OT David van Dijk Yale University MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 (..)

Community Day

Broad Institute

SEPTEMBER 30, 2024

Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

Landiolol

New Drug Approvals

APRIL 19, 2025

April 2016). 2016 Apr 25;80(5):1106-7 ^ “Rapibloc Summary of Product Characteristics” (PDF). Shibata SC, Uchiyama A, Ohta N, Fujino Y (April 2016). October 2016). . “Landiolol has a less potent negative inotropic effect than esmolol in isolated rabbit hearts” Journal of Anesthesia. 22 (4): 3616.

FDA

FDA Clinical Trials Treatment Trials

A Long Time Coming: DEA Regs Finally Authorize Schedule II Prescription Partial Fills

FDA Law Blog: Biosimilars

JULY 31, 2023

Houck — President Barack Obama signed the Comprehensive Addiction and Recovery Act of 2016 (“CARA”) intended to reverse serious prescription drug abuse trend in the United States on July 22, 2016. By Larry K.

Long-Term Care Facilities

Long-Term Care Facilities Pharmacy Regulations Drugs

Pfizer quits Duchenne gene therapy, lays off staff following study setback

David Liu receives Breakthrough Prize in Life Sciences

Webinars

Trending Sources

Cases of Drug-Resistant Gonorrhea Have Tripled in China, Posing a Global Threat

Webinars

In Mississippi, a Huge Jump in Cases of Babies Born With Syphilis

This Flu Season Is Worst In A Decade

U.S. Gender-Affirming Surgeries Nearly Tripled in 3 Years

You're Far Less Likely to Get an Opioid Now After Surgery

Mood Disorders Have Increased Among Kids, Teens

US Cocaine Seizure Effectiveness Rate, 2016-2020

Overcoming challenges in biosimilar analytical characterization

EXPRESSION OF CONCERN: The Truncated Human Telomeric Sequence Forms a Hybrid‐Type Intramolecular Mixed Parallel/antiparallel G‐quadruplex Structure in K+ Solution

Possible adulticidal drugs for Onchocerca volvulus

Most prolific drug patent challengers

Most prolific drug patent challengers

Antibody Validation for Flow Cytometry

Auburn University hosts the 60th edition of the Renowned Computational Biophysics Workshop

Fitusiran

TBD

Why GoodRx—Not Amazon—May Be the True PBM Disrupter

Why GoodRx—Not Amazon—May Be the True PBM Disrupter (rerun)

New molecular insights on medical cannabis

Unemployment and underemployment significant drivers of suicide: Analysis

#ScienceSaturday: March 2, 2024

Children in Chile saw 73% fewer TV ads for unhealthy foods and drinks following trailblazing marketing restrictions

Primary care clinics that improved patient access, identified at-risk patients and expanded services experienced reductions in acute hospitalizations

Investigating the intratumoural microbiome in young-onset CRC patients

Therapeutic Oligos 2025 Keynote Speakers Announced

Have You Missed Any FDA Data Submission Requirements? A Look at Substantial Changes and New Requirements

Out-of-Pocket Costs Rising for Neurology Tests, Visits

The rising impact of biomarkers in early clinical development

VODOBATINIB

As Testing Costs Rise, Neurology Patients May Skip Screening

Growth in New/Novel Psychoactive Substances

Large Language Models and Biological Foundation Models

Lightning Talks

TBD

TBD

Microbiome

Molecular dynamics

Tensor factorization + single-cell rna-seq

Single-cell genomics + LLM or OT

Community Day

Landiolol

A Long Time Coming: DEA Regs Finally Authorize Schedule II Prescription Partial Fills

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