Broad Institute

OCTOBER 28, 2024

We wanted to build a tool like that for cell biology. So we took lots of reference single-cell RNA sequencing data from atlases and used our scalable machine learning algorithms to embed all of the gene expression data on these cells into compact vector representations — you can think of these as a signature for each cell.

Engineering 119

Engineering Cell Biology Disease RNA 119

Drug Target Review

JULY 13, 2023

The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0” The underlying biology and processes upon which the company was founded have broad applicability across various human disease areas. Klein notes the importance of Dewpoint’s disease-agnostic approach.

Disease 98

Disease Small Molecule Cell Biology Drugs 98

SCIENMAG: Medicine & Health

AUGUST 30, 2023

The discovery is a significant advance in cell biology, likely solves a long-standing mystery about an unusual feature of some ion channels […]

Cell Biology 83

Cell Biology Drugs Research 83

Chemical Biology and Drug Design

JULY 26, 2023

lncRNA, miRNA, siRNA, receptors, and proteins) are added to exosomes which are released from the parental cells. Abstract Noncoding RNAs (ncRNAs) are engaged in key cell biological and pathological events, and their expression alteration is connected to cancer progression both directly and indirectly.

Engineering 100

Engineering Therapies Cell Biology Drugs 100

SCIENMAG: Medicine & Health

JULY 13, 2023

RESEARCH REVEALS HOW COVID-19 VIRUS INFECTS THE PLACENTA, AND HOW THIS CAN BE PREVENTED Credit: Monash University RESEARCH REVEALS HOW COVID-19 VIRUS INFECTS THE PLACENTA, AND HOW THIS CAN BE PREVENTED In a landmark study published in Nature Cell Biology, Australian researchers, led by Professor Jose Polo from Monash University and the University of (..)

Cell Biology 77

Cell Biology Virus Research 77

Chemical Biology and Drug Design

JANUARY 5, 2024

After the corresponding transfection or treatment with inhibitor of catenin-responsive transcription-3 (iCRT-3), abovementioned CRC cell biological behaviors as well as expression levels of HOXB7 and β-catenin were evaluated. μM THA dwindled CRC cell viability, migration, and invasion, and facilitated apoptosis.

Bioinformatics 100

Bioinformatics Cell Biology Treatment Research 100

Chemical Biology and Drug Design

JULY 27, 2023

DDP-resistant NPC cells were established by treatment with DDP at increased concentrations (2, 4, 6, 8, or 10 μg/mL). Cell biological behaviors were assessed via cell function experiments. MicroRNA-577 and EIF5A2 mRNA expressions were detected by qRT-PCR.

Cell Biology 100

Cell Biology Regulations Treatment Research 100

KIF1A

MARCH 2, 2024

Read the Article Rare Roundup The Jackson Laboratory offers “Exploring Rare Disease Through Translational Research” MiniCourse Human health is incredibly complex; developing safe, effective treatments requires knowledge of molecular mechanisms, cell biology, and drug administration.

Laboratories 119

Laboratories Cell Biology Disease Research 119

Drug Target Review

NOVEMBER 17, 2023

Professor Alan Trounson AO CEO, Executive Director, Cartherics Alan is the past President of the Californian Institute for Regenerative Medicine (2007-2014), the Californian state’s $3 billion stem cell agency driving research in stem cell biology and facilitating the translation of stem cell discoveries into clinical therapies.

Therapies 118

Therapies Clinical Trials Cell Biology Trials 118

Drug Target Review

OCTOBER 16, 2023

Nikki drives adoption of 3D cellular models of human disease by applying her expertise in cell biology to drug discovery and high-throughput screening. About the author Nikki Carter Commercial Organoid Innovation Director, Molecular Devices. Nikki’s life sciences experience spans leadership, commercial and research roles.

Disease 122

Disease Immune Response Cell Biology Treatment 122

Drug Target Review

NOVEMBER 24, 2023

Achieving a mouse brain map has been made possible by advances in computing and data processing, as well as previous work by Lichtman and other researchers like Professor Florian Engert in molecular and cell biology, studying the brains of fruit flies and zebrafish.

Cell Biology 105

Cell Biology Engineering Research Treatment 105

Drug Target Review

NOVEMBER 1, 2023

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of Cell Biology. Umezu-Goto M, Kishi Y, Taira A, et al. 2002 Jul 22;158(2):227–33. Valdés-Rives SA, González-Arenas A. Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development.

Clinical Trials 134

Clinical Trials Trials Small Molecule Disease 134

Drug Target Review

OCTOBER 31, 2023

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

Cell Biology 107

Cell Biology Pharmaceuticals Science Disease 107

Drug Target Review

APRIL 12, 2024

With its disruptive pipetting technology, SEED Biosciences is bridging the gap between the capabilities in liquid handling and the opportunities in single cell biology. He is the CEO and cofounder of SEED Biosciences Ltd, a spinoff from the EPFL.

Cell Biology 105

Cell Biology FDA Approval FDA Research 105

Broad Institute

DECEMBER 13, 2023

Hacohen Group, Cell Circuits Bhaavana Oruganty Swarthmore College Engineering (major), B.S., Chemistry (minor) Golub Lab, Cancer Program Ava Perry Texas A&M University Molecular and Cell Biology (major), B.S., Biochemistry (minor) Golub Lab, Cancer Program Alexander Rojas Emory University Biology B.S.

Molecular Biology 52

Molecular Biology Cell Biology Science Engineering 52

Drug Target Review

APRIL 12, 2024

With its disruptive pipetting technology, SEED Biosciences is bridging the gap between the capabilities in liquid handling and the opportunities in single cell biology. He is the CEO and cofounder of SEED Biosciences Ltd , a spinoff from the EPFL.

Cell Biology 98

Cell Biology FDA Approval FDA Research 98

Drug Target Review

MARCH 3, 2025

Turning this tide, Professor Jens Christian Schwamborn, a cell biology expert at the University of Luxembourg and co-founder of OrganoTherapeutics , is leading a groundbreaking effort to transform our understanding and treatment of these debilitating diseases.

Disease 52

Disease Treatment Therapies Cell Biology 52

The Pharma Data

OCTOBER 27, 2021

million expansion will bring high quality seeds to worldwide markets faster, providing solutions for growers and meeting consumer demands / The seven-hectare global Product Design Center in San Nicolás includes state-of-the-art lab space for cell biology research and greenhouses for seed production.

Cell Biology 40

Cell Biology Production Laboratories Marketing 40

The Pharma Data

SEPTEMBER 21, 2020

The funding will be used to develop a pipeline of ‘highly selective’ gene therapies targeting cancer stem cells in a variety of solid tumour types. It will draw on research led by Professor Steven Pollard at the University of Edinburgh, which delved into stem cell biology, synthetic biology and cancer genomics.

Therapies 52

Therapies Cell Biology Licensing Licensing 52

Broad Institute

FEBRUARY 29, 2024

Prior to joining the platform, Lipinski worked for almost five years as a postdoc with Paola Arlotta at Harvard Department of Stem Cell and Regenerative Biology and Stanley Center for Psychiatric Research. There, he used cortical organoid models of bipolar disorder to study patient response to lithium. Lipinski earned his Ph.D.

Cell Biology 52

Cell Biology Disease Science Research 52

Broad Institute

MARCH 25, 2024

in cell biology. Navarro later became the first in her family to attend a four-year college, earning her degree in microbiology from the University of Texas at El Paso, followed by a stint doing research at Novartis in Cambridge, MA, and then graduate studies at MIT to earn her Ph.D.

Science 111

Science Cell Biology Research DNA 111

Broad Institute

NOVEMBER 2, 2023

We've been using those for a long while, for modeling various aspects of biology like genomic variation, experimental artifacts, single-cell biology, and other areas. Generative AI is something that has been brewing for a long time in the machine learning community, going back to the fundamental tenets of Bayesian statistics.

Research 124

Research Engineering Science Cell Biology 124

Drug Target Review

AUGUST 10, 2023

When bound to GRP78, ID2 loses its inhibitory function, leading to increased invasiveness of cancer cells. Implications for cancer therapeutics and beyond These findings have wide-ranging implications for cancer treatment and cell biology research.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

Drug Target Review

JUNE 7, 2024

She has deep knowledge in Immunology and T cell biology, and 13 years of experience in Research (seven of them in biotech at Immunocore), including pipeline programme leadership. Dr Ribeiro holds a PhD in Biomedical Sciences from University of Porto, Portugal, studying T cell and thymus development.

Engineering 81

Engineering Clinical Trials Therapies Cell Biology 81

The Pharma Data

FEBRUARY 24, 2022

Their findings are published online in Nature Cell Biology. “We are amazed by the efficiency of small-molecule PROTAC in simultaneously targeting EZH2 and cMyc in cancer cells.” MS177 targets both EZH2 and cMyc and thus inhibit cancer growth.

Small Molecule 52

Small Molecule Cell Biology Research Drug Development 52

Drug Target Review

APRIL 9, 2024

Initial works from the lab concentrated on exploring the role of replicative stress in cancer and ageing, for which the group combined cell biology, mouse models and drug development projects. In 2005, he joined CNIO to lead the Genomic Instability Group where he has been ever since.

RNA 64

RNA Clinical Development Cell Biology Disease 64

Drug Target Review

JULY 23, 2024

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. I carried that appetite for knowledge, coupled with a driven work ethic, through my graduate and post-graduate studies at the University College London.

Small Molecule 116

Small Molecule Targeted Protein Degradation Science Disease 116

Alta Sciences

JANUARY 31, 2025

Before joining Altasciences, Ria received a Bachelor of Science from McGill Universitys Department of Anatomy and Cell Biology in 1998, and became a Diplomate of the American Board of Toxicology in October 2016.

Cell Biology 52

Cell Biology Pharmaceutical Companies Clinical Research Government 52

Drug Target Review

AUGUST 24, 2023

Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology. Biophysical Journal. 2021 Jul 6;120(13):2644-56. Springer TA, Dustin ML. Integrin inside-out signaling and the immunological synapse. 2012 Feb 1;24(1):107-15.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

The Pharma Data

JUNE 28, 2021

. • Addie Thompson – Michigan State University • Ana Laura Torres Huerta – Monterey Institute of Technology • Bryan Berger – University of Virginia • Eduardo Rodriguez – Institute of Molecular and Cell Biology of Rosario • Elizabeth Skellam – University of North Texas • Enrico Bonello – Ohio State University • Haoyu Niu – University of California, (..)

Research 52

Research Cell Biology Science Disease 52

KIF1A

MAY 24, 2023

The central scientific goal for this class was to “[conduct] authentic research that studies the consequences of disease-related mutations in a neuronal kinesin (KIF1A), by using behavioral, genetic, and cell biological tools to assay how KIF1A mutations affect C. elegans neurons”.

Disease 98

Disease Laboratories Research Science 98

Drug Target Review

DECEMBER 21, 2023

That creates a resource for scientists, including data science researchers who want to apply machine learning to cell images; now they have more than 200,000 cells they can play with. It also allows scientists to explore hypotheses about the cell biology of undifferentiated stem cells.

International 105

International Science Disease Research 105

Reprocell

NOVEMBER 20, 2023

CHIR99021, also known as CT99021, is a small molecule compound that has proven to be a potent and versatile tool in the world of stem cell biology and regenerative medicine. It acts as a selective inhibitor of glycogen synthase kinase 3 (GSK-3) with a high affinity for GSK-3β.

Research 52

Research Small Molecule Cell Biology 52

The Pharma Data

DECEMBER 1, 2020

Innate has been a pioneer in the understanding of natural killer cell biology and has expanded its expertise in the tumor microenvironment and tumor-antigens, as well as antibody engineering.

Cell Biology 52

Cell Biology Clinical Trials Production Licensing 52

Drug Target Review

JANUARY 31, 2024

Sara holds a bachelor’s degree in Pharmaceutical Sciences and a PhD in Pharmacology and Toxicology from the University of California, Irvine and completed her post-doctoral fellowship training in cardiovascular cell biology from the Lerner Research Institute at the Cleveland Clinic in Ohio.

Clinical Trials 97

Clinical Trials Production Science Research 97

Drug Target Review

SEPTEMBER 19, 2023

From 3D cell culture to organs-on-chips. Trends in Cell Biology. References Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE. Reconstituting Organ-Level Lung Functions on a Chip. 2010;328(5986):1662-8. Huh D, Hamilton GA, Ingber DE. 2011;21(12):745-54. Huh D, Torisawa Y-s, Hamilton GA, Kim HJ, Ingber DE.

Animal Testing 98

Animal Testing Clinical Trials Pharmaceutical Companies FDA 98

The Pharma Data

JANUARY 23, 2021

Particularly in TNBC, collagen remodeling is seen in the stromal compartment [ 3 ]. Assessing Collagen Features at a Finer Level of Detail.

Treatment 52

Treatment Cell Biology Hospitals Clinical Trials 52