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Scientists engineer CRISPR enzymes that evade the immune system

Broad Institute

In both cases, they found that the engineered enzymes resulted in significantly reduced immune responses compared to the original nucleases, but still cut DNA at the same efficiency. Minimally immunogenic nucleases are just one part of safer gene therapies, Zhangs team says. Tan and K.

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AI-Designed Enzymes

Codon

By training PLACER on structures stored in the Protein Data Bank, the team taught the model to predict atom arrangements that follow the physical and chemical rules governing protein-small molecule interactions. They synthesized DNA encoding each protein variant, expressed the proteins in E. Credit: Lauko A.

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David Liu receives Breakthrough Prize in Life Sciences

Broad Institute

Base editing, which Lius team developed in 2016, is a gene editing technique that directly converts an individual DNA base pair into a different base pair. Liu became an HHMI investigator in 2005 and joined the JASONs, academic science advisors to the US government, in 2009.

Science 144
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Can Plants Really “See”?

Codon

Plastic leaves do not emit organic signals and contain no DNA, so any mimicry could imply some kind of primitive vision. Such vascular differences are governed by auxin, a plant hormone that regulates leaf venation and shape.

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Twist Bioscience

Learn More > Variant Libraries Order Now TCR Libraries New Combinatorial Variant Library Spread Out Low Diversity Libraries Site Saturation Libraries Enzyme Screening Kits New Watch how Twist builds variant libraries for your perfect application Synthetic Controls Order Now Liquid Biopsy cfDNA Pan-Cancer Reference Standards v2 New Infectious Disease (..)

RNA 52
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The Silent Architect: How Data Governance Will Decide the Winners and Losers in the AI World

Perficient: Drug Development

But no one talks to or notices the quiet, slightly awkward one in the room, its Data Governance. ” And yet, in almost every great technology story and every technology failure Data Governance is the silent architect whether you called it that or didnt. It was a data governance failure. But in the AI economy?

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Issue 07 is Coming on Monday

Codon

The event hosts will provide snacks and drinks, and the winning teams will get signed copies of our DNA books and free hats. government believed that if they could control the environment, they could also control the food supply. Please RSVP to join. Register here Issue 07 also features: Leech Therapy.