Sat.May 18, 2024 - Fri.May 24, 2024

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SLAS Europe reveals New Product Award finalists

Drug Discovery World

SLAS has announced the finalists for its New Product Award, with the winners to be announced at the annual conference. The SLAS 2024 Europe Conference and Exhibition is heading back to Barcelona, 27-29 May, for its fifth annual European conference. It will feature scientific sessions and keynote presentations, discussion groups, new product demonstrations and extensive exhibition access time.

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Scientists map networks regulating gene function in the human brain

Science Daily: Pharmacology News

A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain's biological pathways and cellular functions. The research used postmortem brain tissue from over 2,500 donors to map gene regulation networks across different stages of brain development and multiple brain-related disorders.

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Stomach Paralysis Risk May Rise in People Taking Ozempic and Similar Drugs

Drugs.com

MONDAY, May 20, 2024 -- New, real-world research confirms that the blockbuster weight-loss drugs that millions of Americans have been taking to shed pounds can trigger stomach paralysis in some patients.“Although these drugs do work and should be.

Drugs 133
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Orna, a circular RNA specialist, acquires a buzzy startup

BioPharma Drive: Drug Pricing

After laying off staff late last year, Orna is expanding through the purchase of ReNAgade Therapeutics, which was built around technology designed to more effectively deliver RNA-based medicines.

RNA 119
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Could a modified cold sore virus cure brain cancer?

Drug Discovery World

A team of scientists in the US and the UK are combining a genetically modified cold sore virus with a cancer vaccine to treat an aggressive type of brain cancer in children. The three-year survival rate for children with high-grade gliomas, without further complications, is only 11-22%, and the currently available treatments, radiotherapy and chemotherapy, can harm the child’s developing brain.

Virus 147
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Birth of universe's earliest galaxies observed for first time

Science Daily: Pharmacology News

Researchers have now seen the formation of three of the earliest galaxies in the universe, more than 13 billion years ago. The sensational discovery contributes important knowledge about the universe.

Research 126

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ASCO24: An early look at cancer drug study results

BioPharma Drive: Drug Pricing

Clinical trial abstracts posted by ASCO Thursday give a peek at anticipated datasets from Immunocore, Merck & Co., J&J and Arcus Biosciences.

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CAS BioFinder Discovery Platform offers drug discovery insights

Drug Discovery World

CAS, a division of the American Chemical Society, has launched the CAS BioFinder Discovery Platform, designed to reveal novel drug discovery insights through data connections. The offering provides drug discovery scientists with the ability to explore known and predicted data, find answers to their questions, and potentially accelerate the preclinical drug discovery process.

Drugs 147
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'Vigorous melting' at Antarctica's Thwaites 'Doomsday' Glacier

Science Daily: Pharmacology News

Glaciologists show evidence of warm ocean water intruding kilometers beneath grounded ice at Thwaites Glacier in West Antarctica. The findings suggest that existing climate models are underestimating the impact of ocean and ice interactions in future sea level rise projections.

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Costs, Side Effects Drive Folks to Quit New Weight-Loss Meds

Drugs.com

THURSDAY, May 23, 2024 -- Three months after starting one of the new GLP-1 weight-loss drugs, more than a quarter of patients have already quit the medications, and by a year from first use more than a third have stopped, new research shows.Reasons.

Research 124
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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With Duchenne decision ahead, FDA’s Marks pushes for speedy gene therapy approvals

BioPharma Drive: Drug Pricing

But the head of the FDA’s CBER office didn’t tip where the agency stands on potentially broadening use of Sarepta’s Duchenne gene therapy Elevidys.

Therapies 119
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Peptide shows promise as therapeutic for bone loss disorders

Drug Discovery World

Birmingham researchers have shown that a naturally occurring peptide holds promise as a new therapeutic for bone loss disorders and could have advantages over existing drugs. PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) was first identified in 2015 by University of Birmingham researchers. The latest research shows for the first time that PEPITEM could be used as a novel and early clinical intervention to reverse the impact of age-related musculoskeletal diseases.

Disease 147
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Mental disorders may spread in young people's social networks

Science Daily: Pharmacology News

A recently completed study demonstrates that mental disorders may be transmitted between individuals within social networks. The finding was the most evident in the case of mood, anxiety and eating disorders.

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Louisiana Votes to Make Abortion Pills Controlled Substances

Drugs.com

FRIDAY, May 24, 2024 -- Louisiana has become the first state to pass a law that designates abortion pills as dangerous controlled substances. Once Gov. Jeff Landry signs the bill into law, as he is expected to do, possession of the drugs.

Drugs 122
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Certain menopausal hormone therapy could raise ovarian cancer risk, study finds

BioPharma Drive: Drug Pricing

The findings, from two trials involving tens of thousands of women, could influence guidelines around the use of hormonal treatment for menopausal symptoms.

Therapies 116
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Discover how organoids bridge the gap between the lab and clinic

Drug Discovery World

Developing new drugs is a complex and often lengthy process. A major roadblock lies in the limitations of traditional preclinical models, which often fail to accurately represent the intricate biology of human patients. Join DDW for a free event on 18 June, 3PM BST to learn more about how patient-derived organoids are revolutionising drug discovery.

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Cement recycling method could help solve one of the world's biggest climate challenges

Science Daily: Pharmacology News

Researchers have developed a method to produce very low emission concrete at scale -- an innovation that could be transformative in the transition to net zero. The method, which the researchers say is 'an absolute miracle', uses the electrically-powered arc furnaces used for steel recycling to simultaneously recycle cement, the carbon-hungry component of concrete.

Research 121
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1 in 9 U.S. Children Have Been Diagnosed With ADHD

Drugs.com

THURSDAY, May 23, 2024 -- About 1 in 9 American children have ever received an ADHD diagnosis, slightly more than the number of kids currently being treated for the disorder, a new study shows.About 7.1 million kids (11.4%) have ever been.

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Therapies designed to dismantle cancer’s escape mechanisms show promise for patients

BioPharma Drive: Drug Pricing

Hear from IO Biotech CEO Dr. Mai-Britt Zocca about the potential of therapeutic vaccines to strip the defenses used by cancer cells to keep the immune system at bay.

Therapies 112
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Test predicts obesity patients’ response to Ozempic

Drug Discovery World

A new study has demonstrated the clinical utility of a machine-learning gene risk score biomarker to predict patient response to Ozempic (semaglutide) and reduce variability. The study ‘Performance of a Machine-Learning Gene Risk Score Biomarker on Predicting Response to Semaglutide’ was led by the Mayo Clinic and presented at Digestive Disease Week 2024.

Science 147
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Study explains why the brain can robustly recognize images, even without color

Science Daily: Pharmacology News

New research offers a possible explanation for how the brain learns to identify both color and black-and-white images. The researchers found evidence that early in life, when the retina is unable to process color information, the brain learns to distinguish objects based on luminance, rather than color.

Research 118
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Do Fish Oil Supplements Help or Harm the Heart?

Drugs.com

WEDNESDAY, May 22, 2024 -- Folks regularly taking fish oil supplements might not be helping their health as much as they might think, a new study suggests.Regular use of fish oil supplements could increase the risk of first-time heart disease and.

Disease 122
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AstraZeneca sets sights on $80B in revenue by 2030

BioPharma Drive: Drug Pricing

The U.K. pharma expects to launch 20 new drugs by then, among them complex medicines for cancer as well as treatments for weight loss.

Treatment 120
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New DDW Highlights podcast: 21 May 2024

Drug Discovery World

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. From a weight loss drug that prevents heart attacks and a gene therapy that restores hearing, to a vaccine that can treat viruses that don’t exist yet, our chosen news stories this week all represent potential breakthroughs in their respective fields.

Virus 147
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Brain 'assembloids' mimic human blood-brain barrier

Science Daily: Pharmacology News

Major advance promises to accelerate the understanding and improved treatment of a wide range of brain disorders, including stroke, cerebral vascular disorders, brain cancer, Alzheimer's disease, Huntington disease, Parkinson's disease, and other neurodegenerative conditions.

Disease 119
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Use of GLP-1 Meds Have Risen 7-Fold Among Young Americans

Drugs.com

WEDNESDAY, May 22, 2024 -- The number of American teens and young adults who've been prescribed one of the new GLP-1 weight-loss drugs soared nearly seven-fold between 2020 and 2023, a new report finds. That's compared to an overall decline of.

Drugs 117
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What are PDX-Derived Organoids (PDXOs)?

Crown Bioscience

Learn about PDX-derived organoids, including PDXO establishment and utility in a pioneering drug discovery platform combining the benefits of in vitro PDXO and highly predictive in vivo PDX models.

Drugs 98
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New product could aid successful production of mRNA therapeutics

Drug Discovery World

Takara Bio has launched PrimeCap T7 RNA Polymerase (low dsRNA), a mutant T7 RNA polymerase suitable for mRNA therapeutic research and development. PrimeCap T7 RNA Polymerase is a mutant T7 RNA polymerase that has been genetically engineered to maintain high-performance RNA synthesis activity while reducing dsRNA production to less than 10%. Further genetic modifications have resulted in a four-fold reduction of cap analogue concentration in the IVT reaction whilst maintaining a capping efficienc

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Charge your laptop in a minute or your EV in 10? Supercapacitors can help

Science Daily: Pharmacology News

Imagine if your dead laptop or phone could charge in a minute or if an electric car could be fully powered in 10 minutes. New research could lead to such advances.

Research 118
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Shared Fentanyl Pipe Residue a New Overdose Danger

Drugs.com

THURSDAY, May 23, 2024 -- San Francisco researchers report that smoking has now replaced injections as the most common way of ingesting illicit fentanyl.That switch has created a potentially deadly new danger, however, as fentanyl residues slowly.

Research 116
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New patent for Ferring Pharms drug NOCDURNA

Drug Patent Watch

Annual Drug Patent Expirations for NOCDURNA Nocdurna is a drug marketed by Ferring Pharms Inc and is included in one NDA. It is available from one supplier.

Drugs 105
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Machine learning: A useful tool in the development of next generation antibody therapeutics

Drug Discovery World

Ben Holland , CTO and Co-Founder of Antiverse discusses how artificial intelligence and machine learning are benefitting antibody discovery and design. Modern experimental procedures, such as immunisation, B-cell screening, and synthetic library generation, have been pivotal in developing approximately 80 FDA-approved antibody therapeutics. This remarkable progress in antibody modalities for disease treatment is a testament to the effectiveness of these methods, and they remain key for many use

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Ancient viral DNA in the human genome linked to major psychiatric disorders

Science Daily: Pharmacology News

New research has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

DNA 114
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Stroke Rates Are Rising, Especially Among the Young

Drugs.com

THURSDAY, May 23, 2024 -- The rate at which Americans under the age of 65 suffered a stroke rose by about 15% between 2011 and 2022, new government data shows.That was true even among the young: The rate of stroke jumped 14.6% among people ages 18.