Sat.May 18, 2024 - Fri.May 24, 2024

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The Potential of Cannabichromene (CBC) as a Therapeutic Agent [Minireview]

ASPET

There is a growing interest in the use of medicinal plants to treat a variety of diseases, and one of the most commonly used medicinal plants globally is Cannabis sativa. The two most abundant cannabinoids ( 9 -tetrahydrocannabinol and cannabidiol) have been governmentally approved to treat selected medical conditions; however, the plant produces over 100 cannabinoids, including cannabichromene (CBC).

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AI headphones let wearer listen to a single person in a crowd, by looking at them just once

Science Daily: Pharmacology News

Engineers have developed an artificial intelligence system that lets someone wearing headphones look at a person speaking for three to five seconds to 'enroll' them. The system then plays just the enrolled speaker's voice in real time, even as the pair move around in noisy environments.

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Stomach Paralysis Risk May Rise in People Taking Ozempic and Similar Drugs

Drugs.com

MONDAY, May 20, 2024 -- New, real-world research confirms that the blockbuster weight-loss drugs that millions of Americans have been taking to shed pounds can trigger stomach paralysis in some patients.“Although these drugs do work and should be.

Drugs 133
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ASCO24: An early look at cancer drug study results

BioPharma Drive: Drug Pricing

Clinical trial abstracts posted by ASCO Thursday give a peek at anticipated datasets from Immunocore, Merck & Co., J&J and Arcus Biosciences.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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New patent for Merck Sharp drug BELSOMRA

Drug Patent Watch

Annual Drug Patent Expirations for BELSOMRA Belsomra is a drug marketed by Merck Sharp Dohme and is included in one NDA. It is available from one supplier.

Drugs 105
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Brain 'assembloids' mimic human blood-brain barrier

Science Daily: Pharmacology News

Major advance promises to accelerate the understanding and improved treatment of a wide range of brain disorders, including stroke, cerebral vascular disorders, brain cancer, Alzheimer's disease, Huntington disease, Parkinson's disease, and other neurodegenerative conditions.

Disease 139

More Trending

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Lilly to pour $5B more into expanding Zepbound, Mounjaro production

BioPharma Drive: Drug Pricing

The planned spending on new facilities in Lebanon, Indiana, brings its total commitment to the site to $9 billion, the largest single manufactuing investment in company history.

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New patent for Ferring Pharms drug NOCDURNA

Drug Patent Watch

Annual Drug Patent Expirations for NOCDURNA Nocdurna is a drug marketed by Ferring Pharms Inc and is included in one NDA. It is available from one supplier.

Drugs 105
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Birth of universe's earliest galaxies observed for first time

Science Daily: Pharmacology News

Researchers have now seen the formation of three of the earliest galaxies in the universe, more than 13 billion years ago. The sensational discovery contributes important knowledge about the universe.

Research 138
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Costs, Side Effects Drive Folks to Quit New Weight-Loss Meds

Drugs.com

THURSDAY, May 23, 2024 -- Three months after starting one of the new GLP-1 weight-loss drugs, more than a quarter of patients have already quit the medications, and by a year from first use more than a third have stopped, new research shows.Reasons.

Research 124
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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AstraZeneca sets sights on $80B in revenue by 2030

BioPharma Drive: Drug Pricing

The U.K. pharma expects to launch 20 new drugs by then, among them complex medicines for cancer as well as treatments for weight loss.

Treatment 119
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Satellite glial cells bridge sensory neuron crosstalk in visceral pain and cross-organ sensitization [Minireview]

ASPET

Following colonic inflammation, the uninjured bladder afferent neurons are also activated. The mechanisms and pathways underlying this sensory neuron cross-activation (from injured neurons to uninjured neurons) are not fully understood. Colonic and bladder afferent neurons reside in the same spinal segments and are separated by satellite glial cells (SGCs) and extracellular matrix in dorsal root ganglia (DRG).

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Scientists map networks regulating gene function in the human brain

Science Daily: Pharmacology News

A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain's biological pathways and cellular functions. The research used postmortem brain tissue from over 2,500 donors to map gene regulation networks across different stages of brain development and multiple brain-related disorders.

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Do Fish Oil Supplements Help or Harm the Heart?

Drugs.com

WEDNESDAY, May 22, 2024 -- Folks regularly taking fish oil supplements might not be helping their health as much as they might think, a new study suggests.Regular use of fish oil supplements could increase the risk of first-time heart disease and.

Disease 122
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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With Duchenne decision ahead, FDA’s Marks pushes for speedy gene therapy approvals

BioPharma Drive: Drug Pricing

But the head of the FDA’s CBER office didn’t tip where the agency stands on potentially broadening use of Sarepta’s Duchenne gene therapy Elevidys.

Therapies 117
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Evaluation of Systemic and Brain Pharmacokinetic Parameters for Repurposing Metformin Using Intravenous Bolus Administration [Drug Discovery and Translational Medicine]

ASPET

Metformin's potential in treating ischemic stroke and neurodegenerative conditions is of growing interest. Yet, the absence of established systemic and brain pharmacokinetic (PK) parameters at relevant pre-clinical doses presents a significant knowledge gap. This study highlights these PK parameters and the importance of using pharmacologically relevant pre-clinical doses to study pharmacodynamics (PD) in stroke and related neurodegenerative diseases.

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'Vigorous melting' at Antarctica's Thwaites 'Doomsday' Glacier

Science Daily: Pharmacology News

Glaciologists show evidence of warm ocean water intruding kilometers beneath grounded ice at Thwaites Glacier in West Antarctica. The findings suggest that existing climate models are underestimating the impact of ocean and ice interactions in future sea level rise projections.

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1 in 9 U.S. Children Have Been Diagnosed With ADHD

Drugs.com

THURSDAY, May 23, 2024 -- About 1 in 9 American children have ever received an ADHD diagnosis, slightly more than the number of kids currently being treated for the disorder, a new study shows.About 7.1 million kids (11.4%) have ever been.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Orna, a circular RNA specialist, acquires a buzzy startup

BioPharma Drive: Drug Pricing

After laying off staff late last year, Orna is expanding through the purchase of ReNAgade Therapeutics, which was built around technology designed to more effectively deliver RNA-based medicines.

RNA 117
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Platelet Spreading and Clot Retraction are Regulated by two Distinct {alpha}IIb{beta}3 Outside-in Signaling Pathways [Cardiovascular]

ASPET

Bi-directional signaling through platelet integrin α IIb β 3 is essential in hemostasis and thrombosis. In quiescent platelets α IIb β 3 is in a low-affinity ligand binding state. However, upon platelet activation by agonists through inside-out signaling, a rapid switch in the conformation of the integrin results in a high affinity ligand binding state capable of binding soluble fibrinogen.

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Charge your laptop in a minute or your EV in 10? Supercapacitors can help

Science Daily: Pharmacology News

Imagine if your dead laptop or phone could charge in a minute or if an electric car could be fully powered in 10 minutes. New research could lead to such advances.

Research 131
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Blood Pressure Meds Raise Fracture Risks for Those in Nursing Homes

Drugs.com

MONDAY, May 20, 2024 -- Blood pressure medications appear to more than double the risk of life-threatening bone fractures among nursing home residents, a new study warns.

Nurses 119
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Certain menopausal hormone therapy could raise ovarian cancer risk, study finds

BioPharma Drive: Drug Pricing

The findings, from two trials involving tens of thousands of women, could influence guidelines around the use of hormonal treatment for menopausal symptoms.

Therapies 114
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Myocardial SERCA2 protects against cardiac damage and dysfunction caused by inhaled bromine. [Toxicology]

ASPET

Myocardial sarcoendoplasmic reticulum calcium ATPase 2 (SERCA2) activity is critical for heart function. We have demonstrated that inhaled halogen (chlorine or bromine) gases inactivate SERCA2, impair calcium homeostasis, increase proteolysis, and damage the myocardium ultimately leading to cardiac dysfunction. To further elucidate the mechanistic role of SERCA2 in halogen induced myocardial damage we utilized bromine exposed cardiac specific SERCA2 knockout (KO) mice (tamoxifen administered SER

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Mental disorders may spread in young people's social networks

Science Daily: Pharmacology News

A recently completed study demonstrates that mental disorders may be transmitted between individuals within social networks. The finding was the most evident in the case of mood, anxiety and eating disorders.

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Use of GLP-1 Meds Have Risen 7-Fold Among Young Americans

Drugs.com

WEDNESDAY, May 22, 2024 -- The number of American teens and young adults who've been prescribed one of the new GLP-1 weight-loss drugs soared nearly seven-fold between 2020 and 2023, a new report finds. That's compared to an overall decline of.

Drugs 117
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AltruBio lands up to $225M after shift to immune drug research

BioPharma Drive: Drug Pricing

Since pivoting from oncology, the startup has raised close to $300 million and advanced an ulcerative colitis drug into mid-stage testing.

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Immunogenic Treatment for Metastatic Breast Cancer Using Targeted Carbon Nanotube Mediated Photothermal Therapy in Combination with Anti-PD-1 [Cellular and Molecular]

ASPET

The high prevalence of breast cancer is a global health concern, but there are no safe or effective treatments for it at its advanced stages. These facts urge the development of novel treatment strategies. Annexin A5 (ANXA5) is a natural human protein that binds with high specificity to phosphatidylserine, a phospholipid tightly maintained in the inner leaflet of the cell membrane on most healthy cells but externalized in tumor cells and the tumor vasculature.

Therapies 100
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A promising approach to develop a birth control pill for men

Science Daily: Pharmacology News

Researchers show in animal models that a novel, non-hormonal sperm-specific approach offers a promising option for reversible human male contraception.

Research 131
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Shared Fentanyl Pipe Residue a New Overdose Danger

Drugs.com

THURSDAY, May 23, 2024 -- San Francisco researchers report that smoking has now replaced injections as the most common way of ingesting illicit fentanyl.That switch has created a potentially deadly new danger, however, as fentanyl residues slowly.

Research 116
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Therapies designed to dismantle cancer’s escape mechanisms show promise for patients

BioPharma Drive: Drug Pricing

Hear from IO Biotech CEO Dr. Mai-Britt Zocca about the potential of therapeutic vaccines to strip the defenses used by cancer cells to keep the immune system at bay.

Therapies 111
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What are PDX-Derived Organoids (PDXOs)?

Crown Bioscience

Learn about PDX-derived organoids, including PDXO establishment and utility in a pioneering drug discovery platform combining the benefits of in vitro PDXO and highly predictive in vivo PDX models.

Drugs 98
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Study explains why the brain can robustly recognize images, even without color

Science Daily: Pharmacology News

New research offers a possible explanation for how the brain learns to identify both color and black-and-white images. The researchers found evidence that early in life, when the retina is unable to process color information, the brain learns to distinguish objects based on luminance, rather than color.

Research 130