Broad Institute

JULY 26, 2022

Learn more COVID-19 portals and datasets Broad data scientists and software engineers have developed several portals and datasets to support COVID-19-related research. Learn more Genome Analysis Toolkit (GATK) Industry standard for identifying SNPs and indels in germline DNA- and RNA-seq data.

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Compound Screening FDA Approval Engineering RNA 52

Drug Target Review

AUGUST 10, 2023

1 The research, supported by the National Institutes of Health, centres on a cellular chaperone protein called GRP78, responsible for regulating protein folding within cells. In the top row, human lung cancer cells were engineered to over-express GRP78 in the nucleus. Previous studies led by Dr Amy S.

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Cell Biology Small Molecule Regulations Engineering 52

Vial

DECEMBER 5, 2023

Transforming Genomics Research Next-generation sequencing (NGS) enables comprehensive genome sequencing and has transformed genomics research, offering vastly improved capabilities for analyzing DNA and RNA in a high-throughput and cost-effective manner. We have built a global, full-service CRO powered by intuitive end-to-end technology.

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Clinical Trials Trials RNA Bioinformatics 52

The Pharma Data

MARCH 23, 2022

Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase. But targeting Ebola virus polymerase has proven tough. To our knowledge, this is the first time GSPT1 has been linked to viral infection.”

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Codon

JUNE 5, 2025

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. This article provides a summary of the major CRISPR systems, 2 including the naturally occurring CRISPR-Cas9, -Cas12, and -Cas13 systems, as well as base editors, prime editors, and the recently uncovered bridge RNA system.

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Codon

JUNE 25, 2024

Kamal Nahas highlights the biological limits on cell division speed and explores how we might engineer cells to grow faster. coli to clone DNA, engineering this microbe to divide more quickly would greatly accelerate research. Proteins are colored blue and RNA molecules are colored orange and yellow.

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Codon

APRIL 2, 2024

A gene encoding green fluorescent protein was placed alongside one of the three promoters, and as the engineered cells cycled from one gene to the next, they blinked between green—dark—green—dark. The RNA Exporter , which was developed by Felix Horns and others in my lab, is one example. And he was also in Heidelberg.

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Codon

APRIL 19, 2023

To combat these threats, genetic engineers are making bananas that fend off fungi or ripen slower than natural varieties. This gene is regulated, in turn, by a small arsenal of other proteins from the MaMADS family. ( Friedman’s engineered bananas stay yellow for more than a month after being plucked from a tree.

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DNA RNA Engineering Regulations 52

Codon

APRIL 19, 2023

To combat these threats, genetic engineers are making bananas that fend off fungi or ripen slower than natural varieties. This gene is regulated, in turn, by a small arsenal of other proteins from the MaMADS family. ( Friedman’s engineered bananas stay yellow for more than a month after being plucked from a tree.

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DNA RNA Engineering Regulations 52

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. Read Biological Engineering mScarlet3: a brilliant and fast-maturing red fluorescent protein. Thanks for skimming. ❤️ Subscribe to support human writers. Gungabeesoon J. Nature Aging. Nature Methods.

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Codon

MARCH 20, 2023

🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Basic Science A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Biological Engineering Generation of functional oocytes from male mice in vitro. Metabolic Engineering.

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Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer. Often, when we engineer a cell, we only mess with the magnitude of an effect; this study suggests that we should think more about the timing, too. From Zhang et al.

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Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer. Often, when we engineer a cell, we only mess with the magnitude of an effect; this study suggests that we should think more about the timing, too. From Zhang et al.

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Codon

JULY 27, 2023

But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. Because it turns out that at least half of them , in humans, also bind to RNA molecules. RNA export systems.

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Codon

JULY 27, 2023

But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. Because it turns out that at least half of them , in humans, also bind to RNA molecules. RNA export systems.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

APRIL 9, 2023

LanzaTech announced a partnership with H&M Move to convert factory carbon emissions into fabrics using engineered microbes. Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. RNA may offer a safer form of pest control in the future. Shrock E.L.

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Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Genetic engineering can be used to eradicate mosquitoes in two ways: Through gene drives or the “sterile insect technique.” Stahl et al.

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Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Genetic engineering can be used to eradicate mosquitoes in two ways: Through gene drives or the “sterile insect technique.” Stahl et al.

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Vaccine DNA Virus Engineering 52

The Pharma Data

MARCH 4, 2021

We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline.

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Codon

MARCH 24, 2024

In the first real test of delivering a complex biomolecule to over a billion people, little has changed from how Genentech first approached manufacturing in the 1980s; Cells are genetically engineered and then grown in steel tanks. But this isn’t a problem with extracts.

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Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. And it’s been my life for the last few weeks. A Mycoplasma cell.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. And it’s been my life for the last few weeks. A Mycoplasma cell.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

NOVEMBER 1, 2024

Scientists are already building a model that can, for example, look at which RNA molecules are expressed in a cell at t=0 and predict how those molecules will change at t=1. SeqFISH, developed by Long Cai’s group at Caltech, maps the spatial positions of thousands of RNA, DNA, or protein molecules within single cells.

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The Pharma Data

AUGUST 3, 2021

The company and MiNA Therapeutics Limited announced a global research collaboration to develop novel drug candidates using MiNA’s proprietary small activating RNA (saRNA) technology platform. The company announced the acquisition of Protomer Technologies Inc.,

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Production Marketing Research Government 52

Codon

SEPTEMBER 22, 2024

This method uses a chemical to inhibit DNA methylation, along with a genetic modification to activate expression of key transcription factors which regulate the expression of many other genes, inducing the cells to differentiate to an oogonia-like state. Human and mouse cells also have several differences in gene regulation.

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DNA Laboratories Regulations Therapies 122

Codon

AUGUST 26, 2024

Remdesivir and other broad-spectrum antivirals work by jamming up RNA-dependent RNA polymerase (RdRp), an enzyme that nearly all RNA viruses use to replicate their genomes. Other efforts to build broad-spectrum antivirals have focused on another conserved feature of viruses: double-stranded RNA.

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RNA Virus DNA Vaccine 109

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. As Richard Dawkins said of biological wheels : “the engineering solution can be seen in plain view, yet [it is] unattainable in evolution because it lies [on] the other side of a deep valley.”

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RNA DNA Vaccine Virus 105

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study.

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Broad Institute

MAY 29, 2025

Related news New approach reveals genomes' sequence and structure directly within cells Approaching the genome like an engineer Master of microscopy Broad Institute researchers have developed a technology that provides new insight into how disruptions in the nucleus of the cell can impact health and disease.

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DNA RNA Cell Biology Disease 133

Codon

APRIL 10, 2025

.” While we humans can’t yet perfectly replicate cellular function, we can engineer, co-opt, and coerce cells to do so on our behalf. Any effort to engineer a cell, though, should begin with a catalog of its parts. coli and engineered strains that act as living “camera film.” Sign up for Asimov Press.

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Codon

FEBRUARY 19, 2025

ESM is a protein language model that captures certain aspects of protein structure and function, for example, but is blind to DNA or RNA-level features that drive cell behavior. Evo 2 was trained on DNA sequences but can make predictions about myriad aspects of biology, including RNA stability and protein structures.

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Codon

AUGUST 28, 2024

And finally, people intent on causing harm could engineer pathogens to become more dangerous. But DNA screening tools can't simply flag any sequence that is similar to a potentially dangerous virus because the public databases also include engineered sequences comprising DNA sequences created from multiple different organisms.

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DNA Bioinformatics Virus Government 105

The Pharma Data

SEPTEMBER 8, 2020

is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. For more information, visit. www.merck.com. and connect with us on. For more information, visit. www.novavax.com. and connect with us on. A further list and descriptions of these risks, uncertainties and other factors can be found in.

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The Pharma Data

SEPTEMBER 8, 2020

About Moderna Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. For more information, visit www.merck.com and connect with us on Twitter , Facebook , Instagram , YouTube and LinkedIn. For more information, visit www.novavax.com and connect with us on Twitter and LinkedIn.

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Science Vaccine Clinical Trials Pharmaceutical Companies 52

Codon

AUGUST 10, 2023

Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. ” Foundations Basics of Synthetic Biology →Foundations for engineering biology , by Endy D. Gene Expression and Regulation. Link Regulating synthetic gene networks in 3D materials , by Deans T.L.

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DNA Cell Biology Molecular Biology Engineering 98

Drug Target Review

MAY 8, 2025

While reducing mutant huntingtin is desirable, the wild-type huntingtin protein plays crucial roles in normal neuronal function, including vesicular transport, synaptic function and transcriptional regulation. We observed robust AAV vector distribution across key brain regions along with significant guide RNA and nuclease expression.

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Codon

MAY 29, 2025

This class of drugs was engineered to mimic the body’s glucagon-like peptide-1 hormone (GLP-1), which decreases blood glucose levels by activating its receptor to signal the release of insulin. The ADC approach allows healthy cells to avoid the deadly effects suffered by the cancer cells as their RNA polymerase II enzymes are shut down.

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