Drug Target Review

NOVEMBER 7, 2024

Agonist antibodies of immune checkpoint regulators These represent a groundbreaking class of immunotherapeutic agents that mimic the natural function of endogenous ligands by binding to specific cell-surface receptors. This approach augments the strength of achieving immune homeostasis.

Disease

Drug Target Review

OCTOBER 6, 2023

This master regulator of the regulatory T cell (Treg) genome has opened new horizons in the fight against cancer, offering a precise and tailored solution to modulate the immune system’s response. Our team has created proprietary techniques to engineer Tregs that specifically remove SRC-3 that is expressed in the nucleus.

Small Molecule

Broad Institute

MARCH 14, 2024

In one approach, they mark targeted proteins with “destroy me” tags that work with small molecules known as molecular glues to prompt the cell’s own protein-clearing machinery to gobble up the proteins. Continuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues. March 14, 2024.

Targeted Protein Degradation

Drug Target Review

JULY 13, 2023

They found that although the targets themselves may not be easily druggable due to their disordered nature, their ability to condense can be modulated using small molecules. By focusing on molecules that modulate the condensate formation, they identified tractable chemical matter that specifically impacted the target of interest.

Disease

The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Sheng Professor of Biomedical Engineering. ” An Effective On/Off Switch.

Engineering

The Pharma Data

JANUARY 19, 2021

But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts. The authors suggest natural tracr-L regulates autoimmunity. In bacteria with unaltered tracr-L, levels of CRISPR-related genes were low. And removing tracr-L altogether greatly increased CRISPR-Cas9 expression.

Research

Drug Target Review

AUGUST 10, 2023

1 The research, supported by the National Institutes of Health, centres on a cellular chaperone protein called GRP78, responsible for regulating protein folding within cells. In the top row, human lung cancer cells were engineered to over-express GRP78 in the nucleus. Previous studies led by Dr Amy S.

Cell Biology

LifeSciVC

DECEMBER 6, 2022

That can be a good thing: for example, when determining inherited traits and regulating critical cell functions. Put simply, because Transcription Factors lack a catalytic engine, the traditional playbook of using substrate site inhibitors to modulate cellular activity does not work.

Small Molecule

The Pharma Data

DECEMBER 17, 2020

Kurtz brings more than 26 years of experience in global manufacturing, engineering, supply chain, CMC development and program management for drugs and devices at various stages of development. Prior to Aktana, Daveynis served as vice president of engineering at Verint and held prior leadership roles at Capsilon, Quantros, HP, and Kodak.

Small Molecule

The Pharma Data

MARCH 23, 2022

The researchers found that Ebola virus polymerase leverages host protein GSPT1 to positively regulate viral transcription – a process the virus uses to convert its genetic material into instructions for making viral proteins. . “To our surprise, Ebola virus can subvert host restriction imposed by GSPT1 and UPF1,” says Fang.

Virus

The Pharma Data

OCTOBER 14, 2020

Tonix is a clinical-stage biopharmaceutical company focused on discovering, licensing, acquiring and developing small molecules and biologics to treat and prevent human disease and alleviate suffering. The CNS portfolio includes both small molecules and biologics to treat pain, neurologic, psychiatric and addiction conditions.

Vaccine

The Pharma Data

DECEMBER 15, 2020

We believe this small molecule platform has the potential beyond actinic keratosis and are leveraging the platform to develop therapies for other oncology indications.”. Mr. Peter Guenter, CEO of Almirall, stated, “We are delighted to partner with Athenex to market Klisyri in the U.S. and in Europe.

FDA Approval

Advarra

JANUARY 11, 2024

Some of these approaches involve directly isolating the patient’s immune cells and simply expanding their quantity, while other treatments involve genetically engineering their immune cells to enhance cancer-fighting capabilities. Monoclonal Antibodies Monoclonal antibodies are lab-engineered immune system proteins.

Vaccine

LifeSciVC

APRIL 27, 2023

Three best-in-class molecules in the clinic, over $400 million invested and over $4 billion returned to equity holders, all while focused on our mission to design breakthrough medicines for patients. Shortly after the Sotyktu approval, our 260 patient Phase 2b study read out. dermatologist, could not contain his excitement.

Small Molecule

DrugBank

FEBRUARY 26, 2025

Quorum sensing , a process by which bacteria communicate to regulate group behaviors, is one promising target. Advances in genetic engineering have enabled researchers to enhance bacteriophage efficacy and overcome bacterial resistance mechanisms. Regulators are also adapting to the urgency of the antibiotic resistance crisis.

Therapies

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. Read Biological Engineering mScarlet3: a brilliant and fast-maturing red fluorescent protein. Read Prime editing is a tool to make small DNA insertions or deletions without cleaving the genome. Fishman C.B.

DNA

Codon

MARCH 20, 2023

🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Biological Engineering Generation of functional oocytes from male mice in vitro. Marine biofilm engineered to produce current in response to small molecules. Metabolic Engineering. Metabolic Engineering.

Virus

The Pharma Data

MARCH 4, 2021

We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. selective GABA A receptor agonist.

Treatment

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer. Often, when we engineer a cell, we only mess with the magnitude of an effect; this study suggests that we should think more about the timing, too. From Zhang et al.

Vaccine

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer. Often, when we engineer a cell, we only mess with the magnitude of an effect; this study suggests that we should think more about the timing, too. From Zhang et al.

Vaccine

The Pharma Data

JANUARY 13, 2021

TNX-1500 is a third generation anti-CD40-ligand mAb that has been designed by protein engineering to decrease Fc?RII Tonix is a clinical-stage biopharmaceutical company focused on discovering, licensing, acquiring and developing small molecules and biologics to treat and prevent human disease and alleviate suffering.

Pharmaceuticals

The Pharma Data

AUGUST 3, 2021

whose proprietary peptide- and protein-engineering platform is used to identify and synthesize molecules that can sense glucose or other endogenous modulators of protein activity. The company announced the acquisition of Protomer Technologies Inc., Loxo Oncology at Lilly and Kumquat Biosciences Inc.

Production

The Pharma Data

OCTOBER 28, 2020

Our R&D Engine continued to advance our Wave 1 pipeline, with 7 new regulatory filings anticipated within the next 12 months, and we expanded our cell therapy capabilities, both of which will help drive Takeda’s future growth. . billion to date. Press release ). Press release ). Press release ).

Therapies

Agency IQ

NOVEMBER 3, 2023

None of the products discussed thus far should be confused with “synthetic biotics” “Synthetic biotics,” also referred to as engineered living therapeutics , are bacteria that have been genetically altered to perform a specific function for diagnostic or therapeutic benefit. The regulation of dietary supplements in the U.S.

Therapies

Drug Target Review

DECEMBER 13, 2024

Engineering sites on the antibody to enable specific and consistent attachment of the cytotoxic drug to achieve an optimal drug-to-antibody ratio (DAR). 19,20 While novel CPI and ADC combinations are still relatively new, a well-studied example of CPI combinations is PD-1/PD-L1 with cytotoxic t-lymphocyte associated protein 4 (CTLA-4).

Therapies

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study.

Engineering

Codon

DECEMBER 12, 2024

It’s difficult to imagine any evolutionary path that could “reverse” the tangled molecules of life into their mirrored forms, because incremental mutations which swap out a few chiral molecules for their enantiomers would impair or kill the cell. The report maps out at least three options.

RNA

The Pharma Data

SEPTEMBER 8, 2020

Its broad portfolio of oncology product candidates includes individualized and off-the-shelf mRNA-based therapies, innovative chimeric antigen receptor T cells, bi-specific checkpoint immuno-modulators, targeted cancer antibodies and small molecules. For more information, visit. www.novavax.com. and connect with us on.

Science

The Pharma Data

SEPTEMBER 8, 2020

Its broad portfolio of oncology product candidates includes individualized and off-the-shelf mRNA-based therapies, innovative chimeric antigen receptor T cells, bi-specific checkpoint immuno-modulators, targeted cancer antibodies and small molecules.

Science

Codon

MARCH 26, 2023

Link Biological Engineering *Photosynthesis re-wired on the pico-second timescale. Link *Design of Four Small-Molecule-Inducible Systems in the Yeast Chromosome, Applied to Optimize Terpene Biosynthesis. Link A Genetic Programming Approach to Engineering MRI Reporter Genes. Metabolic Engineering. Antika T.R.

DNA

Codon

MAY 29, 2025

While small-molecule drugs continue to play a critical role in modern medicine, we are witnessing a shift toward the increasing development of amino acid-based therapeutics. This exemplifies how we can enhance natural molecular weapons through strategic engineering while preserving their core evolutionary advantages.

Drugs