Drug Target Review

JULY 10, 2025

Absorption, distribution, metabolism, excretion and toxicity – collectively known as ADMET – are among the most critical and challenging hurdles in small molecule drug discovery. Inductive Bio’s approach hinges on drawing a clear line between commercially sensitive information and scientifically valuable data.

Metabolic Stability

The ChEMBL-og

JULY 10, 2025

ChEBI has for the past >20 years provided the biological community with access to definitive small molecule information and data, including accurate representations of often complex chemical structures. It has a growing user base numbered in the hundreds of thousands and with millions of accesses each year.

Small Molecule

LifeSciVC

JULY 8, 2025

Dynamic Subordination Principle: Let the Best Information Lead Based on the leadership framework of Mike Hayes, former SEAL Team TWO Commander Mike Hayes introduced the concept of dynamic subordination as a response to the limits of rigid hierarchy. One team might be working on a cell therapy, another on RNA, another on small molecules.

Hospitals

Sygnature Discovery

APRIL 7, 2025

Small molecule solutions Our strategy to deliver therapeutically relevant ADCs is based on our expertise in four key areas: Holistic development of novel antibody drug conjugates Our comprehensive antibody drug conjugate framework integrates in vitro and in vivo profiling to optimize potency, efficacy, and safety. Big ADC problem?

Small Molecule

New Drug Approvals

APRIL 2, 2025

1] [2] It is a non- opioid , small-molecule analgesic that works as a selective inhibitor of Na v 1.8 “International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 90” WHO Drug Information. Suzetrigine CAS 2649467-58-1 Weight Average: 473.4 World Health Organization (2023).

FDA

New Drug Approvals

JULY 10, 2025

“Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema” Journal of Medicinal Chemistry. Retrieved 9 July 2025 – via Business Wire. October 2022). 65 (20): 13629–13644. doi : 10.1021/acs.jmedchem.2c00921.

FDA

New Drug Approvals

MAY 26, 2025

Ervogastat CAS 2186700-33-2 Non-alcoholic Steatohepatitis (NASH) with Liver Fibrosis (FAST TRACK – U.S.) 2-[5-[(3-Ethoxy-2-pyridinyl)oxy]-3-pyridinyl]- N -[(3 S )-tetrahydro-3-furanyl]-5-pyrimidinecarboxamide ( S )-2-(5-((3-Ethoxypyridin-2-yl]oxy]pyridin-3-yl)- N -(tetrahydrofuran-3-yl)pyrimidine-5-carboxamide PF 06865571 BSOIY5AKQW 407.4

Small Molecule

New Drug Approvals

APRIL 18, 2025

“International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 82” WHO Drug Information. Retrieved 16 December 2024 via PR Newswire. World Health Organization (2019). hdl : 10665/330879. 1 November 2022). 6 (Supplement_1): A618. doi : 10.1210/jendso/bvac150.1281.

FDA

PPD

APRIL 14, 2025

Ideally, the dietitian and dietary information/tools are centralized to ensure all stakeholders patients and site personnel alike receive consistent counseling across all sites. It is vitally important, however, that diet and exercise information be attuned to the cultural and economic makeup of patients.

Clinical Trials

Drug Patent Watch

JANUARY 13, 2025

This data can help build confidence among stakeholders and inform decision-making at both the clinical and policy levels. A: While both aim to provide more affordable alternatives to brand-name drugs, biosimilars are highly similar versions of complex biologic medicines, whereas generic drugs are exact copies of small molecule drugs.

Biosimilars

Molecular Design

DECEMBER 31, 2024

My pulse will be quickenin' With each drop of strychnine We feed to a pigeon It just takes a smidgin To poison a pigeon in the park Tom Lehrer, Poisoning Pigeons in the Park | video ** Ill be reviewing the H2024 study (Occurrence of Natural Selection in Successful Small Molecule Drug Discovery) in this post. fold and it's worth ).

Small Molecule

BioPharma Drive: Drug Pricing

JULY 14, 2025

Skip to main content CONTINUE TO SITE ➞ Dont miss tomorrows biopharma industry news Let BioPharma Dives free newsletter keep you informed, straight from your inbox. into a “ center of excellence ” that will produce a wide range of small molecules and biologic drugs, including protein-degrading “PROTACs” and antibody-drug conjugates.

Production

ASPET

OCTOBER 8, 2024

Overall, these new insights around the effects of ABL TKIs on platelet function could inform the development of targeted therapies with reduced hematologic toxicities. Significance Statement This study examines the effects of clinically relevant small molecule BCR-ABL tyrosine kinase inhibitors (TKIs) on platelet activity.

Small Molecule

Chemical Biology and Drug Design

JANUARY 29, 2024

While a number of sPLA 2 inhibitors have been described, compounds which have been co-crystallized with human sPLA 2 enzymes are of much importance as such three-dimensional structures provide valuable information regarding the structural requirements of good potency inhibitors as well as the molecular interactions between the enzyme and inhibitor.

Small Molecule

Drug Hunter

AUGUST 15, 2023

Clinical advancement of LRRK2 inhibitors was initially stalled by concerns about on-target lung findings in primates, but these were ameliorated by a Merck/Genentech/Pfizer/MJFF study showing that these lung changes were reversible, and Biogen/Denali has currently a small molecule (BIIB122/DNL151) in Ph. I ( NCT04557800 ).

Small Molecule

Drug Hunter

MAY 31, 2023

This article compiles 20+ recent small molecules of general interest in the news in April 2023, with structures where they are available. Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples. Get ahead now by requesting a trial. already a member?

Small Molecule

Metabolite Tales Blog

APRIL 10, 2024

Table 1: Small molecule drugs approved by the FDA in 2023 with reported involvement of phase II mechanisms In vitro : In vivo differences Incubation of the SGLT2 (sodium-glucose co-transporter-2) inhibitor bexagliflozin in human liver microsomes points to metabolism through both oxidation and glucuronidation to 6 main metabolites.

Small Molecule

The ChEMBL-og

OCTOBER 23, 2024

But here's the catch: while ChEMBL provides extensive information on a molecule's activity and cross references to other data sources, it doesn't always tell us if a 3D structure is available for a specific drug-target complex. This can be a roadblock for researchers who need that structural information to design effective drugs.

Small Molecule

Metabolite Tales Blog

JANUARY 23, 2024

Metabolism of 2023 FDA Approved Small Molecules – PART 1 By Julia Shanu-Wilson 2023 was a fruitful year for drug approvals by the FDA, with a crop of 34 small molecules out of a total of 55 new drugs [1]. References [1] 2023 Novel Small Molecule FDA Drug Approvals. link] [4] Licea Perez et al.,

Small Molecule

Dark Matter Blog

APRIL 4, 2023

The bulk of my nearly three decades of experience up to that point was with drugging protein targets using a variety of modalities, but principally small molecules. With this information, we can make meaningful choices about the potential ligandability of sub‑structures inside cells. the targeted RNA in cells or cell lysates.

Small Molecule

Metabolite Tales Blog

APRIL 4, 2023

Metabolism of 2022 FDA approved small molecule drugs part 2 Mixing it Up By Julia Shanu-Wilson In Part 1 of this topic we looked at metabolism of the small molecule drugs approved by the FDA in 2022 that were mediated by CYP3A4. We hope it was a useful two-parter! We’re looking forward to the next crop!

Small Molecule

Drug Target Review

JULY 4, 2023

These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. 2 However, when dosed at the MTD, ADCs display improved efficacy over small molecules in oncology trials. 3D rendering of Antibody Drug Conjugate Molecules.

Small Molecule

The Pharma Data

JULY 29, 2021

Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Kumquat Biosciences today announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses.

Small Molecule

Drug Hunter

JUNE 26, 2023

This article compiles recent high-profile clinical readouts and related news with small molecules of general interest and structures where they are available. Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples. Get ahead now by requesting a trial.

Small Molecule

DrugBank

MAY 15, 2024

One approach is to look beyond the traditional drug molecule. Researchers are experimenting with biologics—larger biological molecules that can do things small molecules can't, like targeting larger, more complex structures on cell surfaces or even inside cells.

Small Molecule

DrugBank

JULY 24, 2024

These multifunctional small molecules are like tiny spies, hijacking the body’s natural protein degradation system to remove unwanted proteins. Multifunctional Small Molecules and Peptides Beyond PROTACs, there are other exciting tools in the new drug discovery toolbox.

Small Molecule

Drug Target Review

OCTOBER 6, 2023

Could you provide more information about CoRegen’s SRC small-molecule inhibitor (SMI) and SRC small-molecule enhancer (SMs) within your portfolio? We have a strong IP on SRC-3 covering any method of cell editing, including Treg engineering, molecular inhibitor and small-molecule enhancer patents.

Small Molecule

DrugBaron

FEBRUARY 7, 2022

Finding small molecule drugs is much harder than finding a needle in a haystack – discovering the right arrangement of atoms to bind precisely to a protein target to elicit a particular response is a problem of vast dimensionality. Yet the situation with small molecules is even worse.

Small Molecule

The Pharma Data

JANUARY 19, 2021

As part of Aptorum Group’s Acticule infectious disease platform, ALS-4 is a novel orally administered first-in-class small molecule that was developed based on an anti-virulence approach targeting Staphylococcus aureus including MRSA. For more information about Aptorum Group, please visit www.aptorumgroup.com. About ALS-4.

Small Molecule

The Pharma Data

NOVEMBER 19, 2020

The Company is also aiming to leverage the highly conserved structure of the SARS-CoV-2 M pro protease as a basis for the design of novel oral small molecules against predicted future variants of SARS-CoV-2 and other related human viruses. For more information, please visit [link]. View original content: [link].

Small Molecule

The Pharma Data

NOVEMBER 30, 2020

Biohaven acquires exclusive global rights to a portfolio of novel, small-molecule CGRP antagonists. For more information, please visit [link]. More information about Biohaven is available at www.biohavenpharma.com. TOKYO and CAMBRIDGE, England , Dec. Vlad Coric , M.D., About Biohaven. About CGRP.

Small Molecule

DrugBank

MAY 22, 2024

Molecular dynamics (MD) simulations and other computational methods are vital tools in our arsenal , helping us peek into the atomic-level interactions and movements within the protein, helping reveal potential new binding sites induced by small molecule interactions. DNA and RNA are also key players, each bringing unique challenges.

Small Molecule

Broad Institute

JUNE 30, 2023

It then extracts features from images of stained cells and creates cellular profiles, categorizing cells based on patterns (often imperceptible to the human eye) that they share with other cells, which directly inform disease biology. That teaches us far more than looking for just a single informative data point.”

Small Molecule

NIH Director's Blog: Drug Development

OCTOBER 30, 2018

Now comes word of another absolutely incredible use of cryo-EM: determining with great ease and exquisite precision the structure of the smaller organic chemical compounds, or “small molecules,” that play such key roles in biological exploration and drug development. Also analyzed were eight less-familiar small molecules.

Small Molecule

The Pharma Data

DECEMBER 20, 2020

ALS-4 is a novel small molecule adopting an anti-virulence (non-antibiotic) approach to address the growing unmet medical needs of infections caused by Staphylococcus aureus. For more information about Aptorum Group, please visit www.aptorumgroup.com. About ALS-4. Disclaimer and Forward-Looking Statements.

Small Molecule

DrugBank

OCTOBER 17, 2024

By utilizing high-resolution protein structures obtained through X-ray crystallography, researchers could design small molecules that potently inhibit the SARS-CoV-2 main protease, a key enzyme essential for viral replication.

Drug Development

DrugBaron

JANUARY 31, 2024

Intelligence (artificial or organic) makes the best use of the available information to guide future decisions. But that presumes that the necessary information to make a better decision exists and is available. Only if the necessary information to select valid targets already exists in the totality of the data available.

Pharma R&D