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Scientists apply optical pooled CRISPR screening to identify potential new Ebola drug targets

Broad Institute

After taking images of the cells, they measured overall viral protein and RNA in each cell using the CellProfiler image analysis software, and to get even more information from the images, they turned to AI. Indeed, treating cells with a small molecule inhibitor of UQCRB reduced Ebola infection with no impact on the cell’s own health.

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Future-proofing drug development with GenAI

Drug Target Review

Indications of interest may be ranked according to potential for technical success, depth of the unmet need and likelihood of commercial success for more targeted and informed investments. Such information gaps emphasise the need for clinical data scientists to supervise methodologies. Indication prioritisation. Molecular innovation.

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The rising impact of biomarkers in early clinical development

Drug Target Review

A COU statement will typically include detailed information about how the biomarker will be measured, the analytical method involved and will be supported by various performance characteristics along with the specific clinical context wherein the biomarker is intended for use.

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Altasciences At CPHI Americas 2025

Alta Sciences

Altasciences At CPHI Americas 2025 pmjackson Thu, 07/03/2025 - 13:41 In the ever-changing drug development world, staying agile is essential to enabling more informed decisions, faster. Why does that matter? Beyond the science, what’s exciting is how this technology opens doors. The response?

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A spatial approach to understanding drug dynamics using mass spectrometry imaging

Drug Target Review

Toxicological investigations play a key role in assessing drug safety and, importantly, inform development decisions. Together, they provide a unique picture that combines analytical and spatial information to give a deeper understanding of drug localisation, help to optimise dosing strategies and mitigate off-target effects.

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Protein degraders: chasing undruggable targets

BioPharma Drive: Drug Pricing

Skip to main content CONTINUE TO SITE ➞ Dont miss tomorrows biopharma industry news Let BioPharma Dives free newsletter keep you informed, straight from your inbox. Specially designed small molecule drugs can bring together target proteins with an enzyme that tags them with ubiquitin, thereby marking them for destruction.

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From siloed data to breakthroughs: multimodal AI in drug discovery

Drug Target Review

Unimodality does not allow for mixing data: cell data, images, molecular data, clinical data records, small molecule descriptors, ADME Tox data, transcriptomic data, text-based drug and disease representations, clinical trial protocols, publications and patent data, etc.