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The next phase of the multiomics evolution, powered by AI

Drug Target Review

The dynamic behaviour of RNA transcripts, the regulation and modification of proteins, the lipid composition of membranes, the structural organisation of cells and the spatial context of tissues all play critical roles in disease progression and therapeutic response.

RNA 71
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The rising impact of biomarkers in early clinical development

Drug Target Review

Haemoglobin A1c (HbA1c) is a validated surrogate endpoint for the reduction of microvascular complications associated with diabetes mellitus; reduced HIV-RNA levels serve as an endpoint for HIV disease control; and a reduction in low-density lipoprotein (LDL) cholesterol is used as an endpoint indicating lower likelihood of cardiovascular events.

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The biotech mapping thousands of hidden therapeutic clues

Drug Target Review

This allows the team to spot previously unannotated proteins and study them across multiple biological dimensions – from structure to function, from RNA expression to genetic association. Where science meets strategy The discovery of tens of thousands of novel proteins presents a clear challenge of determining which to prioritise.

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Therapeutic Oligos 2025 Keynote Speakers Announced

Elrig

This second ELRIG meeting on Therapeutic Oligonucleotides brings together esteemed scientists from academia, industry, and other members of the drug discovery community to explore the discovery, validation, and targeting of oligonucleotide-based drug candidates, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).

RNA 59
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Optical density and absorbance measurements | BMG LABTECH

BMG Labtech

Absorbance measurements at this specific wavelength can be used to determine DNA or RNA concentrations quickly. The conversion of a substrate by the enzyme bound to the secondary antibody into a chromophore is used to allow for measurement by absorbance and quantification of the amount of the specific protein present in the sample.

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Role(s) of G3BPs in human pathogenesis [Minireview]

ASPET

Ras- G TPase-activating protein (SH 3 domain)- b inding p roteins (G3BP) are RNA binding proteins that plays a critical role in stress granule (SG) formation. SGs protect critical mRNAs from various environmental stress conditions by regulating mRNA stability and translation to maintain regulated gene expression.

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Decoding stem cells for personalised regenerative medicine

Drug Target Review

In research published in Scientific Reports , 1 investigators focused on mesenchymal stem cells (MSCs), known for their potential in treating cell defects and regulating immune responses. In the lab, they labelled RNA molecules with fluorescent markers, enabling them to easily locate them within individual cells.

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