National Drug & Alcohol Research Centre Blog

DECEMBER 4, 2023

Kendal Chidwick NDARC’s Kendal Chidwick discusses the findings from a recently published study that examined how patterns of opioid agonist treatment medicines have changed over the past decade. Other changes around this time aimed at improving treatment accessibility included increased use of take-home doses and telehealth appointments.

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Treatment Community Pharmacies Pharmacy International 133

Drug Target Review

JUNE 9, 2023

This exclusive interview with Dr Sharon Benzeno, Chief Commercial Officer, Immune Medicine at Adaptive Biotechnologies, unveils some ground-breaking research on T- cell therapy for cancer , which has seen the first TCR-based therapeutic candidate progress to clinical development, offering promising advancements in innovative cancer treatments.

Treatment 105

Treatment Packaging Clinical Research Therapies 105

ASPET

JUNE 10, 2024

We previously reported that short-term treatment with SLO at relatively high concentrations (10-1000 ng/mL) diminished acetylcholine-induced, endothelial-dependent relaxation in a concentration-dependent manner. In this study, treatment of rat aorta with endothelium with SLO (0.1-10 In vivo SLO treatment (46.8

Treatment 100

Treatment Production 100

Covalent Modifiers

JULY 25, 2024

Our results highlight advantages in developing covalent inhibitors, such as USP30-I-1, for targeting USP30 as treatment of disorders with impaired mitophagy.

Biochemical Assays 182

Biochemical Assays Small Molecule Treatment Disease 182

SCIENMAG: Medicine & Health

JUNE 26, 2023

CDT, Tuesday, June 27, 2023)—By monitoring early-response biomarkers in men undergoing 177Lu-PSMA prostate cancer treatment, physicians can personalize dosing intervals, significantly improving patient outcomes.

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Treatment 82

Drug Target Review

MARCH 7, 2024

1 Although pancreatic cancer is rarer than the abovementioned cancers, it claims over 50,000 lives each year in the United States because of a lack of effective treatments. Since then, two therapies have been approved for use in lung and breast cancer but it did not advance pancreatic cancer treatment.

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Treatment Therapies Clinical Trials Research 98

Chemical Biology and Drug Design

FEBRUARY 25, 2025

A combination of network pharmacology and invitro validation was used to reveal the potential targets and molecular mechanisms of resveratrol for CRS treatment. Together, the present study systematically clarified the possible mechanisms of RES in the treatment of CRS and provided new ideas for the drug research of this disease.

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Treatment Disease Drug Research Research 100

Drug Target Review

APRIL 7, 2025

Susceptibility or risk biomarkers can detect the likelihood of a patient developing a disease or medical condition, which is crucial for treatments that are most effective before the onset of symptoms. A biomarker is a measurable indicator of a biological process, disease state, or response to a treatment.

Clinical Development 69

Clinical Development Clinical Trials Clinical Pharmacology Trials 69

ASPET

JUNE 4, 2024

The goal of the present study was to determine the antiarthritic potential of the minor cannabinoid 8 -THC using the collagen-induced arthritis (CIA) mouse model. The 8 -THC treatment (30 mg/kg) reduced paw swelling and qualitative signs of arthritis.

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Treatment Disease Production 186

Drug Target Review

OCTOBER 25, 2023

Their findings may result in new treatments for reproductive conditions. He stated that this could inform new treatments for reproductive conditions like recurrent pregnancy loss and preeclampsia. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester.

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Treatment Virus Research Science 105

Chemical Biology and Drug Design

OCTOBER 25, 2023

UAN rats possessed prominent levels of serum creatinine, UA, cys-C, and NGAL, which all reduced after hispidulin treatment in a dose-dependent manner. HE staining determined the improvement of kidney injury after treatment, which was comparable to the efficacy of febuxostat.

Treatment 100

Treatment Drugs Research 100

SCIENMAG: Medicine & Health

JUNE 8, 2023

ECU Centre for Precision Health Clinical Professor Adnan Khattak presented the trial’s latest results at the 2023 American Society of Oncology (ASCO) congress in Chicago this week, the biggest […]

Treatment 90

Treatment Vaccine Trials Research 90

PLOS: DNA Science

MARCH 28, 2024

FDA classifies it as a “nonsteroidal treatment” – not a gene therapy, but it affects gene expression. A Scant Protein with Outsize Importance Slowing the muscle decline of DMD presents two huge challenges: the ubiquity of muscle and a giant gene. The gene presents a complex landscape. million DNA bases.

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FDA Approval Treatment FDA DNA 96

ASPET

OCTOBER 23, 2024

The delayed nature of cerebral ischemia secondary to SAH-related vasculopathy presents a window of opportunity for the evaluation of well-tolerated neuroprotective agents administered soon after ictus. Based on allometric scaling of both toxicological and efficacy data, the therapeutic margin in man should be at least 2.

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Clinical Development Treatment Pharmacokinetics Drugs 100

Drug Target Review

JULY 12, 2023

Molecular-level biochemical assays like transcriptomics, genomics and proteomics have emerged as valuable tools for identifying potential targets in cancer treatment through deep cyclic inhibition (DCI). How does the DCI mechanism compare to the design of other drugs for cancer treatment?

Biochemical Assays 98

Biochemical Assays Treatment Bioinformatics Disease 98

SCIENMAG: Medicine & Health

JUNE 27, 2023

Copenhagen, Denmark: More women are having just one embryo transferred per cycle of fertility treatment to get pregnant, according to research presented at the 39th annual meeting of the European Society of Human Reproduction and Embryology (ESHRE) [1].

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Treatment Research 69

Chemical Biology and Drug Design

DECEMBER 15, 2023

Due to the complex pathological processes underlying neurodegeneration, at present, there is no viable therapy available for neurodegenerative disorders. Abstract Neurodegenerative disorders, which affect millions worldwide, are marked by a steady decline of neurons that are selectively susceptible.

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Disease Therapies Treatment Research 189

Covalent Modifiers

AUGUST 8, 2023

3c05899 Owing to their remarkable pharmaceutical properties compared to those of noncovalent inhibitors, the development of targeted covalent inhibitors (TCIs) has emerged as a powerful method for cancer treatment. Herein, we present the first compound capable of covalently engaging both K-Ras(G12D) and K-Ras(G12C) mutants.

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Treatment Pharmaceuticals Drugs 130

SCIENMAG: Medicine & Health

JUNE 17, 2023

CHICAGO—By being undiagnosed or untreated, a significant fraction of people with obesity or overweight are not getting the recommended care, despite an increase in new treatment options, according to research being presented on June 17 at ENDO 2023, the Endocrine Society’s annual meeting in Chicago, Ill.

Treatment 66

Treatment Research 66

Covalent Modifiers

DECEMBER 22, 2023

APOD53 forms a covalent adduct with a reactive cysteine residue present in the TRF2TRFH domain and induces phenotypes consistent with TRF2TRFH domain mutants. These include induction of a telomeric DNA damage response, increased telomeric replication stress, and impaired recruitment of RTEL1 and SLX4 to telomeres.

DNA 162

DNA Regulations Treatment 162

SCIENMAG: Medicine & Health

MARCH 20, 2024

Milan, Italy: Using a combined scanning technique on patients with early-stage breast cancer improved treatment in almost three out of ten cases in a trial presented at the 14th European Breast Cancer Conference today (Thursday). [1]

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Treatment Doctors Trials 68

SCIENMAG: Medicine & Health

JULY 31, 2023

PDT CONTACT: Camille Jewell cjewell@vancomm.com or 202-248-5460 Research Shows Filter Tip Stent Retrievers May Allow Neurointerventionalists to Remove Blood Clots on the First Try During Stroke Treatment SAN DIEGO—Research presented today at the Society of NeuroInterventional Surgery’s (SNIS) 20th Annual Meeting shows that different types […] (..)

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Treatment Research 71

Drug Patent Watch

DECEMBER 9, 2024

” – Dr. Vandana Shiva, Environmental Activist and Author Navigating the Patent Landscape for Natural Products Patenting natural products presents unique challenges. Taxol: From Pacific Yew to Cancer Treatment Taxol (paclitaxel), a widely used cancer drug, was originally isolated from the bark of the Pacific yew tree.

Drugs 97

Drugs Drug Development Pharmaceuticals Production 97

ASPET

JULY 13, 2023

Significance Statement Results presented in this paper, for the first time, implicate the dynamin DNM2 in ocular surface epitheliopathy. We conclude that exposure to tBHP or nitrogen mustard, two different oxidative stress agents, cause corneal epitheliopathy via different pathological pathways.

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Small Molecule Treatment 100

Drug Target Review

MAY 23, 2024

What is the main advantage of TriTCE Co-Stim over conventional CD3-engaging bispecific T cell engagers (TCEs) in the treatment of solid tumours? These challenges are related in part to limited intratumoural T cell availability and poor T cell function (T cell anergy) commonly present in solid tumours. The lead CLDN18.2

Treatment 69

Treatment Engineering Therapies Research 69

National Institute on Drug Abuse: Nora's Blog

MARCH 6, 2025

Advancing reduction of drug use as an endpoint in addiction treatment trials astewart Thu, 03/06/2025 - 09:59 Nora's Blog March 18, 2025 Image Getty Images/ SolStock This blog was also published in the American Society of Addiction Medicine (ASAM) Weekly on March 18, 2025.&

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Treatment Trials Clinical Trials Drugs 69

Conversations in Drug Development Trends

NOVEMBER 21, 2023

Despite significant progress, there are more than 6,500 rare diseases without a single approved treatment. There are so many patients suffering from diseases that have no treatments. We are committed to supporting reimbursement and exploring ways to increase patient access to treatments. “We

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Disease Treatment Clinical Trials Clinical Development 78

Conversations in Drug Development Trends

NOVEMBER 12, 2024

Cell therapy can be effective, but clinically testing the treatment presents several logistical challenges that require early planning and rigorous management by specialized and experienced teams throughout the clinical trial timeline.

Therapies 72

Therapies Clinical Supply Clinical Trials Trials 72

FDA Law Blog: Biosimilars

APRIL 13, 2025

LYTGOBI was granted accelerated approval for the treatment of adult patients with previously treated, unresectable, locally advanced, or metastatic intrahepatic cholangiocarcinoma (iCCA) with FGFR2 gene fusions or rearrangements. Join us as we break down what went wrong this time. What Happened?

Drugs 52

Drugs FDA Trials Treatment 52

ASPET

NOVEMBER 17, 2023

Ketamine is a new, potent and rapid-acting antidepressant approved for therapy of treatment-resistant depression, which has a different mechanism of action than currently-available antidepressant therapies. It owes its uniquely potent antidepressant properties to a complex mechanism of action, which currently remains unclear.

Therapies 100

Therapies Treatment Drugs 100

SCIENMAG: Medicine & Health

JUNE 15, 2023

Breast cancer medications, called aromatase inhibitors, may lessen the effect of weight loss drugs, according to a new study being presented Friday at ENDO 2023, the Endocrine Society’s annual meeting in Chicago, Ill.

Treatment 72

Treatment Drugs 72

SCIENMAG: Medicine & Health

JUNE 18, 2023

Receiving rapid access to testosterone therapy reduced feelings of gender dysphoria and led to a clinically significant reduction in depression as well as a 50% reduction in suicidality among transgender and gender diverse adults, according to research being presented Sunday at ENDO 2023, the Endocrine Society’s annual meeting in Chicago, Ill.

Treatment 69

Treatment Therapies Research 69

SCIENMAG: Medicine & Health

MARCH 28, 2024

DETROIT – A groundbreaking study published in the journal iScience presents crucial insights into the ocular effects of Zika virus infection during pregnancy and offers promising avenues for therapeutic intervention.

Virus 67

Virus Treatment Research 67

Chemical Biology and Drug Design

MAY 11, 2023

Abstract Parkinson's disease is among the most common forms of neurodegenerative illness, with present treatment being primarily symptomatic and frequently coming with substantial adverse effects. The figure depicts the neuroprotective role of crocin in Parkinson's disease.

Disease 100

Disease Research Clinical Trials Treatment 100

ASPET

SEPTEMBER 20, 2024

The present studies evaluated the reinforcing effects of both compounds in monkeys under several conditions. Recently, several modafinil analogues reduced cocaine SA in rats and monkeys, including JJC8-088, characterized as "cocaine like" in rats, and JJC8-091, characterized as "atypical" and not SA by rats. mg/kg/injection), and JJC8-091 (0.1-3.0

FDA Approval 100

FDA Approval Treatment FDA Drugs 100

SCIENMAG: Medicine & Health

JULY 26, 2023

Although a precursor lesion to EAC, called Barrett’s esophagus (BE), is present in roughly seven percent of middle-aged adults, less than one percent of BE patients will progress to EAC, making it difficult to determine which individuals […]

Treatment 68

Treatment 68

FDA Law Blog: Biosimilars

DECEMBER 4, 2023

A prescription not issued in the usual course of professional treatment or in legitimate, authorized research is not a prescription within the meaning of the CSA and the pharmacist knowingly filling it, along with the prescriber issuing it, is subject to penalties. 21 U.S.C. § 829; 21 C.F.R. Holiday CVS, L.L.C. d/b/a CVS/Pharmacy, Nos.

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Pharmacy Government Treatment Compliance 139