article thumbnail

Scientific workflow for hypothesis testing in drug discovery: Part 2 of 3

Drug Target Review

For instance, a dataset generated to study protein expression in one context might also reveal valuable information about other biological pathways or processes. Additionally, exploratory analyses can be valuable for identifying new biological markers or hypotheses.

Drugs 69
article thumbnail

Spirulina’s role in shaping the future of preventative biologics

Drug Target Review

Traditional biologics often involve recombinant protein expression in mammalian cells or microbes like E. Finrow notes that their intellectual property strategy required new types of patents and trade secrets, as spirulina-based therapies had not been fully explored in the biotech space.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Building Korro Bio: A CEO’s Perspective on Innovation and Risk Management

LifeSciVC

This concept of effecting a protein change. was based on experience building on the understanding that a single protein variant, could have markedly different outcomes for patients with chronic kidney disease. We built our proprietary OPERA platform ( here ), leveraging oligonucleotide guided RNA editing to modulate protein expression.

RNA 67
article thumbnail

The Magic of Fast Feedback Loops

Codon

One such opportunity, for example, is in protein expression. When working with proteins — or designing new ones — scientists must first express them within a cellular “host,” which in turn demands that the proteins be successfully translated and folded into a stable, soluble structure.

article thumbnail

FDA Issues “Cliffs Notes”-style Guidance on Cell and Gene Therapy; What Questions Did They Answer? (Part 1)

FDA Law Blog: Drug Discovery

Valentine On November 19, 2024, FDA released a draft guidance titled Frequently Asked Questions Developing Potential Cellular and Gene Therapy Products. The draft guidance describes various methods to assess either cell distribution for cell therapy products or vector biodistribution for gene therapy products.

article thumbnail

Breaking Barriers in Solid Tumor Research: Precision Medicine & Strategic Operations

Conversations in Drug Development Trends

This approach improves treatment outcomes over traditional broad-spectrum therapies, which are prone to more side effects and adverse events. Carefully crafted enrichment strategies optimize recruitment and enrollment, ensuring that the included participants will likely respond to the therapy.

article thumbnail

Ketamine produces antidepressant effects by inhibiting histone deacetylases and upregulating hippocampal BDNF levels in a DFP-based rat model of Gulf War Illness [Toxicology]

ASPET

We previously showed that epigenetic histone dysregulations were associated with decreased Brain Derived Neurotrophic Factor (BDNF) expression in a GWI rat model. GWI has no effective therapies. Ketamine (KET) has recently been approved by the FDA for therapy-resistant depression. mg/kg s.c.,