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The Biotech Startup Contraction Continues… And That’s A Good Thing

LifeSciVC

Beyond simply backing great science (separating the wheat from the chafe), setting a company up properly is critical, and early choices can get locked into the DNA of the company. Some continue to do so today, unfortunately, but there appears to be less of it happening. Second, great teams of truly experienced leaders are scarce.

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Driving Toward Nanopores

Codon

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

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The science of ageing and restoring healthspan

Drug Target Review

Modifications to the epigenome, such as DNA hypermethylation, modify the expression of genes by increasing or decreasing their expression without altering the genes themselves. One way we are doing this at Life Biosciences is through partial epigenetic reprogramming. The epigenome drifts with age, leading to dysregulated gene expression.

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Gene-edited babies: Current techniques not safe, say experts

The Pharma Data

One example of current technology is CRISPR, a biological system for altering DNA discovered in 2012. CRISPR scans the genome looking for the right location, and then uses “molecular scissors” to snip through the faulty DNA. While effective in the lab, the process is less than perfect and can cut out too much DNA.

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The power of combinations in blood cancers

Drug Target Review

At AstraZeneca and beyond we are exploring the use of cell-free DNA (cfDNA) methods to assess minimal residual disease as a possible intermediate endpoint across several disease types. 2012);12(4):237-251. Front Pharmacol. 2018;9:1300. Published 2018 Nov 13. doi:10.3389/fphar.2018.01300 2018.01300 Vanneman M, Dranoff G.

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AstraZeneca unveils The Discovery Centre (DISC) in Cambridge

The Pharma Data

Important discoveries have included Francis Crick and James Watson’s DNA advance in 1953, and Professor Sir John Gurdon’s work on stem cells in 2012. Over the once century, roughly 50 Nobel Prize winners in chemistry and physiology or drug have been associated with Cambridge. region in the US, and Gothenburg in Sweden.

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ViiV Healthcare Announces Analysis Showing no Antiretroviral Therapy Interruptions Due to COVID-19 Across its Clinical Development Programme for Investigational, Long-Acting Cabotegravir and Rilpivirine

The Pharma Data

INSTIs, like cabotegravir, inhibit HIV replication by preventing the viral DNA from integrating into the genetic material of human immune cells (T-cells). Shionogi joined in October 2012. This step is essential in the HIV replication cycle and is also responsible for establishing chronic infection.