Broad Institute

JANUARY 14, 2025

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. The wife-and-husband team started a lab at the Broad with a singular focus: preventing and treating prion disease within their lifetime.

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LifeSciVC

OCTOBER 13, 2022

This puts a premium on companies with a critical mass of know-how today and with real platforms that can more easily and quickly enable programs in different diseases by switching out the DNA construct. This know-how and the assets and capabilities that come out of it cannot be built overnight. million price.

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Therapies Disease Treatment Marketing 40

BMG Labtech

DECEMBER 20, 2024

Whether it is determining concentrations of molecules like proteins or DNA, looking at enzyme kinetics for crucial reactions, or measuring something as fundamental as cell growth, you will find references to absorbance or optical density measurements. 2013) Cell Viability Assays. Lets start by looking at some definitions. Anal Biochem.

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DNA Science Laboratories RNA 52

Drug Target Review

SEPTEMBER 4, 2023

5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. Trends in Parasitology. (35): Guillermo, S.,

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PLOS: DNA Science

JUNE 13, 2024

Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. The Likely Predecessor of SARS-CoV-2 – From my Past Blog Posts I wrote 100+ DNA Science blog posts during the pandemic about the virus.

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PLOS: DNA Science

MARCH 21, 2024

The history of gene therapy for MLD is compelling – DNA Science covered it for Rare Disease Day in 2021, here. She passed away in 2013. The post Older Siblings Made Possible Just-Approved Gene Therapy for Metachromatic Leukodystrophy appeared first on DNA Science. Photos of the kids are at Liviana’s Journey.

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New Drug Approvals

SEPTEMBER 29, 2024

gingivalis DNA was detected in postmortem cortices from people with AD and healthy controls, and in CSF of AD patients ( Jan 2019 news on Dominy et al., gingivalis infection led to the appearance of bacterial DNA in the brain, increased brain Aβ42 production, neuroinflammation, and hippocampal degeneration. 2013 Jan 1;36(4):665-77.

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Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. Molecular therapy 21 , 109-118 (2013). 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. Münch RC, et al.

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Codon

FEBRUARY 28, 2023

1 One rarely pauses to ponder how so much DNA — let alone sugar, proteins, and everything else — can fit inside such a small vessel. Students learn the basics through words: DNA is transcribed to RNA, which is translated into proteins. How fast does DNA become RNA, or RNA protein? DNA accounts for just one percent.

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Drug Target Review

AUGUST 9, 2023

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

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RNA Regulations Disease DNA 98

Codon

APRIL 19, 2023

In 2013, a Fusarium fungus — called Tropical Race 4 — was identified in Mozambique. In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening. From Elitzur T.

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Codon

APRIL 19, 2023

In 2013, a Fusarium fungus — called Tropical Race 4 — was identified in Mozambique. In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening. From Elitzur T.

DNA 52

DNA RNA Engineering Regulations 52

The Pharma Data

MAY 18, 2021

MMR is a molecular mechanism that functions to correct certain errors that can spontaneously occur during DNA replication. This companion diagnostic (CDx) provides clinicians with a standardised testing option that uses a comprehensive panel of DNA mismatch repair (MMR) biomarkers tested by immunohistochemistry (IHC). CA Cancer J Clin.

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The Pharma Data

FEBRUARY 22, 2022

In 2013, she was appointed Finance Director of the Artémis Group. He is co-founder and non-executive board member of the Hartwig Medical Foundation (large scale DNA analyses) and is a board member of the Center for Personalized Cancer Treatment and leads several innovative precision oncology clinical trials.

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Clinical Trials DNA Science Clinical Development 52

The Premier Consulting Blog

APRIL 25, 2023

ICH Harmonised Guideline M7(R1): Assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk. 5] International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). ICH Harmonised Guideline S10: Photosafety evaluation of pharmaceuticals.

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The Pharma Data

DECEMBER 21, 2020

2013:6;2800-12. 2013:66;79-89. With seven new medicines launched between 2014 and 2020, and a broad pipeline of small molecules and biologics in development, the Company is committed to advance oncology as a key growth driver for AstraZeneca focused on lung, ovarian, breast and blood cancers. Int J Clin Exp Pathol. Keedy VL, et al.

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Treatment Trials Disease FDA 52

The Pharma Data

NOVEMBER 29, 2020

Compared to placebo, participants vaccinated with three HB-101 doses had: a 48 percent reduction in CMV viremia (presence of CMV DNA in the blood); a 42 percent reduction in the use of antiviral therapy; and. no CMV disease (compared to 2 out of 14 cases in the placebo group). 1 Gilbert C and Boivin G.

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Codon

JUNE 30, 2024

Modern biotechnology began in 1972 when biochemists at Stanford University spliced together DNA from two different organisms. The race to exploit recombinant DNA technology was on. A year later, in 2013, in Association for Molecular Pathology v. Myriad Genetics, Inc.,

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Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

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DNA Engineering Science Trials 64

Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

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PLOS: DNA Science

MARCH 30, 2023

Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA). The agency started tracking it in 2013, and the spread accelerated in 2015. The post The New Fungus Among Us, Candida auris appeared first on DNA Science.

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PLOS: DNA Science

MAY 16, 2024

Many of the links below are to some of the 100+ DNA Science posts that I wrote during the pandemic. ” I’ve long thought that SARS-CoV-2, or an immediate viral predecessor, emerged years before 2019 – at least as far back as 2013. appeared first on DNA Science. • Single-cell sequencing.

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Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

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The Pharma Data

NOVEMBER 24, 2020

Lynparza exploits tumour DNA damage response (DDR) in cells/tumours harbouring a deficiency in homologous recombination repair (HRR), such as mutations in BRCA1 and/or BRCA2 , to selectively kill cancer cells. 31,14 (2013): 1748-57. doi:10.1200/JCO.2012.43.1882. 2012.43.1882. 6 Annala, Matti et al. 2017.02.023.

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Treatment DNA Trials Therapies 52

Broad Institute

JANUARY 27, 2025

Morphological insights First developed by Carpenter in 2013 , Cell Painting is an assay designed to image multiple cell organelles at the same time and at scale, painting them different colors such as nuclei blue and mitochondria red. Next, they induce the expression of the DNA-cutting Cas9 enzyme to disable the genes targeted by the guides.

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Codon

MAY 11, 2023

The first lab-grown burger was made for $330,000 back in 2013. link ) A more representative human genome sequence, based on DNA from 47 ethnically diverse people, was published yesterday. The waiting list to rent out a large bioreactor, last I heard, was something like 4 years. Despite the trouble, there is hope.

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Vaccine Engineering Licensing Licensing 52

Codon

MAY 11, 2023

The first lab-grown burger was made for $330,000 back in 2013. link ) A more representative human genome sequence, based on DNA from 47 ethnically diverse people, was published yesterday. The waiting list to rent out a large bioreactor, last I heard, was something like 4 years. Despite the trouble, there is hope.

Vaccine 52

Vaccine Engineering Licensing Licensing 52

Agency IQ

MARCH 29, 2024

2) Update delivery timing and methods to require community water systems that serve 10,000 or more persons to provide reports biannually; and allow electronic delivery methods consistent with the “Safe Drinking Water Act–Consumer Confidence Report Rule Delivery Options” issued by the EPA on January 3, 2013.

Regulations 40

Regulations Compliance Production Government 40

Broad Institute

JANUARY 7, 2025

These stories and diagnoses, made possible by clinical genomics labs around the world analyzing DNA from patients and sharing their findings with each other to improve medical care, werent always so common. NCBI then launched the ClinVar database in 2013 to house that information in a public archive.

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Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

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DNA Cell Biology Molecular Biology Engineering 98

FDA Law Blog: Biosimilars

OCTOBER 24, 2024

In a landmark 2013 decision , a unanimous Supreme Court held that a naturally occurring DNA segment, even when isolated, is a product of nature and therefore does not meet the subject matter eligibility requirement for patentability. animal, viral, bacterial) DNA and RNA sequences. Supporters of AMP v. Bob Cook-Deegan et al.

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Laboratories DNA Testimonials Biosimilars 64

NIH Director's Blog: Drug Development

SEPTEMBER 18, 2014

Today, with rapid DNA sequencing technology, specific genetic signatures can be detected within hours to days, enabling us to draw direct linkages to outbreak sources and to track their spread. This was a rather blunt tool for organism identification, and so precisely pinpointing the origins of a given outbreak was difficult. Note: Anthony S.

Clinical Trials 52

Clinical Trials Vaccine DNA Trials 52

Codon

MARCH 3, 2024

Link DNA Assembly Bottlenecks DNA synthesis has received a great deal of attention, and for good reason. But in 2021, a company reported the first synthesis of a single strand of DNA that stretched more than 10,000 bases in length. There has been far less attention devoted to DNA assembly. Link Secure DNA.

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DNA Engineering Vaccine Virus 103

Codon

NOVEMBER 1, 2024

For example, cloning DNA molecules and inserting them into cells — a process required for basically all experiments in molecular biology — takes up to a week of work. Perhaps you’ve seen this chart before, which shows the falling costs of DNA sequencing over the last two decades. If we could get E.

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Codon

AUGUST 10, 2023

Nature Methods (2013). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. PNAS (2013). . & Reinberg D. Cell (2002).

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DNA Cell Biology Engineering Molecular Biology 52

PLOS: DNA Science

FEBRUARY 29, 2024

I wrote this essay in 2013 , in response to common confusion of “embryo” and “fetus” – never imagining the blurring would extend to “baby” We scientists are sticklers for precision and accuracy. Various right-to-lifers in particular have trashed me, taking exception to my litany of biological facts.

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PLOS: DNA Science

JULY 25, 2024

It appeared in Guinea at the end of 2013 and spread to Liberia and Sierra Leone soon after, where people had no natural immunity. The post Anthony Fauci’s Memoir “On Call” Journeys through a Half Century of Plagues Amid the Politics of Public Health appeared first on DNA Science. Cases and deaths mounted. Would it spread to the US?

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