article thumbnail

A Visual Guide to Gene Delivery

Codon

A gene is the essential hereditary unit that passes traits from parents to offspring; a segment of DNA containing instructions for making a specific protein or molecule that performs a particular function in your body. As methods for resolving errors in DNA continue to advance, it has never been easier to fix a broken gene.

article thumbnail

FDA Eliminates Animal Testing: Impact on Biotechs

The Premier Consulting Blog

5] US FDA Center for Drug Evaluation and Research (CDER) Guideline (2015): Nonclinical Safety Evaluation of Reformulated Drug Products and Products Intended for Administration by an Alternate Route.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

A Visual Guide to Genome Editors

Codon

Certain CRISPR components can add short DNA sequences from the genomes of defeated viruses into the bacterium’s own genome, creating a type of protective “memory.” If the same virus invades the cell a second time, the gRNA’s spacer sequence will bind to the matching viral DNA sequence, then be cut by the Cas protein.

DNA
article thumbnail

Driving Toward Nanopores

Codon

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA
article thumbnail

What Biology Can Learn from Physics

Codon

Einstein predicted the existence of gravitational waves in 1916, but LIGO did not detect them until 2015. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors). Synthesizing that much DNA is cost-prohibitive.

article thumbnail

The power of combinations in blood cancers

Drug Target Review

At AstraZeneca and beyond we are exploring the use of cell-free DNA (cfDNA) methods to assess minimal residual disease as a possible intermediate endpoint across several disease types. 2015);126(1):9-16. 2015);126(4):454-462. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.

article thumbnail

What Biology Can Learn from Physics

Codon

Einstein predicted the existence of gravitational waves in 1916, but LIGO did not detect them until 2015. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors). Synthesizing that much DNA is cost-prohibitive.