Tue.Apr 09, 2024

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Watch the latest DDW vodcast

Drug Discovery World

The latest DDW Sitting Down With sponsored vodcast is now available. It features Dr Adriano Flora, Director of Business Development at The Jackson Laboratory (JAX). In this vodcast, he discusses alternatives to non-human primates, the key benefits of this, and what impact will they have on the future of drug development. Moreover, he answers questions on the key breakthroughs in recent years in this field and how have these impacted future success, as well as challenges in the clinic that must b

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After being insulted, writing down your feelings on paper then getting rid of it reduces anger

Science Daily: Pharmacology News

Researchers have discovered a simple, but effective, strategy to help people reduce their feelings of anger. Disposing of a piece of paper containing your written thoughts on the cause of your anger can effectively neutralize it. This process is like a Japanese tradition called hakidashisara, in which people write their negative thoughts on a plate then destroy it.

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Genetically engineered dendritic cells enhance lung cancer therapy

Drug Discovery World

A study by researchers at the UCLA Health Jonsson Comprehensive Cancer Center in the US suggests that injecting engineered dendritic cells directly into cancerous lung tumours can help promote a stronger immune response. When tested in mice with non-small cell lung cancer (NSCLC), the team discovered that combining this therapy with immune checkpoint blockade made it even more effective.

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Wegovy Helps Those With Both Diabetes, Heart Failure: Study

Drugs.com

TUESDAY, April 9, 2024 -- For people struggling with both diabetes and a common type of heart failure, the weight-loss drug Wegovy may do more for their health than help them shed pounds, new research suggests.In the study, published Saturday in.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Webinar: How can you enhance collaborations with contract partners?

Drug Discovery World

Join DDW and Revvity Signals for this free event ‘ Enhancing collaboration between sponsors and contract partners in drug discovery ’. The event will take place on 23 April at 4pm BST / 5pm CEST / 11am EDT / 8am PDT. Most contemporary drug discovery companies (sponsors) outsource some (or all) drug development to external contract partners, e.g. Contract Research Organisations (CROs) and/or Contract Development and Manufacturing Organisations (CDMOs).

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Do some mysterious bones belong to gigantic ichthyosaurs?

Science Daily: Pharmacology News

Several similar large, fossilized bone fragments have been discovered in various regions across Western and Central Europe since the 19th century. The animal group to which they belonged is still the subject of much debate to this day. A study could now settle this dispute once and for all: The microstructure of the fossils indicates that they come from the lower jaw of a gigantic ichthyosaur.

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Tiny plastic particles are found everywhere

Science Daily: Pharmacology News

Microplastic particles can be found in the most remote ocean regions on earth. In Antarctica, pollution levels are even higher than previously assumed.

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The Top Pharmacy Benefit Managers of 2023: Market Share and Trends for the Biggest Companies—And What’s Ahead

Drug Channels

Three is still the magic number for pharmacy benefit managers (PBMs). For 2023, nearly 80% of all equivalent prescription claims were processed by three companies: the Caremark business of CVS Health, the Express Scripts business of Cigna, and the Optum Rx business of UnitedHealth Group. Read on for Drug Channels Institute’s (DCI’s) latest market share figures, along with a preview of the industry changes that will shift these shares over the next few years.

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Adding Vaccine to Immunotherapy for Liver Cancer Shows Promise in Early Trial

Drugs.com

TUESDAY, April 9, 2024 -- A custom-made anti-tumor vaccine added to standard immunotherapy was twice as likely to shrink liver cancer as when a patient received immunotherapy alone, a new study shows.The vaccine could help liver cancer patients.

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Pfizer, with new study results, seeks to bring RSV shot to adults aged 18-59

BioPharma Drive: Drug Pricing

The company plans to submit the trial data to regulators in a bid to win approval of its vaccine Abrysvo in adults as young as 18 years old.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Some Breast Cancer Patients Can Retain Lymph Nodes, Avoiding Lymphedema

Drugs.com

TUESDAY, April 9, 2024 -- Removal of armpit lymph nodes can leave many breast cancer patients with lingering lymphedema, a painful and unsightly swelling of the arm.Now, new Swedish research may help narrow down which patients require extensive.

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Blood protein could help detect delayed concussion recovery in children

Science Daily: Pharmacology News

Researchers have discovered a blood protein that could help detect which children will experience ongoing concussion symptoms more than two weeks after an injury.

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More Fruits, Veggies, Grains Will Get to Kids Under New WIC Rule

Drugs.com

TUESDAY, April 9, 2024 -- Changes to the federal program that helps pay for groceries for low-income moms and their young children means that soon these families will have access to more fruits, vegetables and whole grains, U.S. health officials.

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How nucleolar stress accelerates aging in mice

Drug Target Review

How has nucleolar stress (NS) been linked to age-related diseases, and what approach did researchers use to investigate its toxicity? The nucleolus (and nucleolar stress) had been previously linked to aging and age-related diseases such as cancer or degeneration. Several studies had shown nucleolar alterations in these diseases, and even correlations between nucleolar activity and lifespan.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Stopping Aspirin a Month After Stent Implant Helps Heart Patients

Drugs.com

TUESDAY, April 9, 2024 -- People who've survived a heart attack and have been given a stent may be better off quitting low-dose aspirin a month after the procedure, a new study finds.The strategy is "beneficial by reducing major and minor bleeding.

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LatinX@Broad Presents The René Salazar Speaker Series: Juan Alvarez-Dominguez

Broad Institute

LatinX@Broad Presents The René Salazar Speaker Series: Juan Alvarez-Dominguez By Rose Circeo April 9, 2024 Breadcrumb Home LatinX@Broad Presents The René Salazar Speaker Series: Juan Alvarez-Dominguez Juan Alvarez-Dominguez Assistant Professor of Cell and Developmental Biology Department of Cell and Developmental Biology University of Pennsylvania Chrono-energetics: Linking Circadian Metabolism to Islet Replacement Therapeutics Learn more about the LatinX@Broad speaker series.

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Can Pregnancy Accelerate Aging for Women? Study Says Yes

Drugs.com

TUESDAY, April 9, 2024 -- Pregnancy transforms women's bodies in many obvious ways, but new research suggests it may also accelerate aging.Women who had been pregnant appeared to be biologically older than women who had never carried a child, the.

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Patient-Centered or Patient-Driven? Exploring New Ways of Patient Collaboration in Modern Healthcare Publishing

Fierce BioTech

Patient-Centered or Patient-Driven? Exploring New Ways of Patient Collaboration in Modern Healthcare Publishing swheeler Tue, 04/09/2024 - 14:38 Thu, 05/23/2024 - 11:00 Resource Type Webinar Bob Perry Heather Gorse Catherine Richards Golini Paul Lavender Duration 60 minutes This webinar focuses on the growing significance and value of co-creation in healthcare education, particularly in the creation of patient information resources.

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Know Your Spring Allergens and the Meds That Can Help

Drugs.com

TUESDAY, April 9, 2023 -- Spring is in the air, and along with it loads of tree, grass and weed pollen.Sneezing, watery and itchy eyes, runny nose and all the other miseries of seasonal allergies can prevent a person from fully enjoying the season.

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Fierce Pharma Forward: Drug Development and Delivery Insights for 2024

Fierce BioTech

Fierce Pharma Forward: Drug Development and Delivery Insights for 2024 Join us for the inaugural Fierce Pharma Forward, a virtual event where industry leaders will explore the latest innovations in drug delivery and development. Throughout this half-day event, experts will dissect key challenges and opportunities, covering topics such as RNA delivery, ultra-long-lasting drug delivery platforms, the latest technologies, and much more. smarcus Tue, 04/09/2024 - 17:05 Join us for the inaugural Fier

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Many Factors Stop U.S. Women From Getting Mammograms

Drugs.com

TUESDAY, April 9, 2024 -- Health care cost and access are not the only barriers women face in getting lifesaving mammograms, a new government report finds.Food insecurity, lack of transportation, less hours at work and feelings of isolation also.

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Enhancing Images with CSS Filters

Perficient: Drug Development

CSS filters offer a rich toolkit for modifying and improving pictures directly within web pages. From subtle adjustments like brightness and contrast to more striking effects like blur, grayscale, and color manipulation, these filters offer a broad variety of effects. You may boost visual appeal and produce distinctive effects with CSS filters, which will improve the way your website looks.

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EPA Cracks Down on Toxins Threatening Those Living Near Chemical Plants

Drugs.com

TUESDAY, April 9, 2024 -- Are you one of the estimated 104,000 Americans who lives within six miles of factories that spew organic chemicals into the air? New rules issued Tuesday by the Environmental Protection Agency might make your life.

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Commercialization Strategies for Cell and Gene Therapies

Fierce BioTech

Commercialization Strategies for Cell and Gene Therapies pesurya Tue, 04/09/2024 - 12:46 Tue, 05/07/2024 - 11:00 Resource Type Webinar Mike Sweeney Joel Wayment Fran Gregory Akshay Peer (Ph.D) Promotion Start Tue, 04/09/2024 - 15:15 Promotion End Wed, 10/09/2024 - 15:15 Duration 60 Minutes With an expanding pipeline of new products, cell and gene therapies (CGTs) hold significant promise across a number of therapeutic areas.

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Can Older Patients With Low-Risk Leukemia Quit Seeing Specialists?

Drugs.com

TUESDAY, April 8, 2024 -- Some slow-growing cases of leukemia don’t need constant surveillance by cancer specialists, a new study claims.Low-risk patients with slow-growing chronic lymphocytic leukemia (CLL) and no symptoms fared well even after.

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Clinical trial recruitment tools for today’s patients

Antidote

Understanding how to recruit patients for clinical trials can be one of the most challenging aspects of performing medical research. Sponsors and sites have more tools at their disposal than ever before, but keeping track of how to use these various outreach methods can be time-consuming. Additionally, using a mix of outreach is typically the best strategy to reach the highest number of potentially qualified patients — meaning observing best practices across marketing disciplines is advised.

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Discoveries from Q&A with Enterprise Data using GenAI for Oracle Autonomous Database

Perficient: Drug Development

Natural language AI has proliferated into many of today’s applications and platforms. One of the high in demand use cases is the ability to find quick answers to questions about what’s hidden within organizational data, such as operational, financial, or other enterprise type data. Therefore leveraging the latest advancements in the GenAI space together with enterprise data warehouses has valuable benefits.

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PureTech launches Seaport, hoping to create Karuna 2.0

BioPharma Drive: Drug Pricing

The startup is taking aim at anxiety with $100 million from high-profile biotech backers like ARCH, Sofinnova and Third Rock.

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Discovering an Antimalarial Drug in Mao’s China

Codon

Wendi Yan writes about the discovery of artemisinin, a medicine that has saved millions of lives, for Issue 01. Drawing on recently published Chinese texts, Wendi’s reporting provides a more comprehensive telling of this discovery than has previously been described. When her father gave Tu the name “Youyou,” he started with characters from the Chinese classic Book of Odes: “The deer bleat: ‘yōu yōu’ while eating wild ‘hāo’” (&#

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Which pharmaceutical companies have the most ointment dosed drugs?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most ointment dosed drugs. For a different perspective, see the most popular dosage types.

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What's quieter than a fish? A school of them

Science Daily: Pharmacology News

Swimming in schools makes fish surprisingly stealthy underwater, with a group able to sound like a single fish. Engineers working with a high-tech simulation of schooling mackerel offer new insight into why fish swim in schools and promise for the design and operation of much quieter submarines and autonomous undersea vehicles.

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Therapeutic antibodies in the fight against Alzheimer’s

Drug Discovery World

ImmunoBrain Checkpoint (IBC) is currently dosing patients in a clinical trial with its monoclonal antibody for Alzheimer’s disease (AD). DDW’s Megan Thomas caught up with Professor Michal Schwartz to learn more about her work and the work being carried out by IBC. MT: Can you provide an overview of your career to date in the field of therapeutic antibodies, and its importance in the field of neuroimmunology?