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FDA Limits COVID-19 Boosters to Seniors, Other High-Risk Groups

Drugs.com

WEDNESDAY May 21, 2025 The U.S. Food and Drug Administration (FDA) has decided that only seniors and people at high risk should get the latest COVID-19 booster shots this fall.The new framework, announced Tuesday, says adults 65 and older, and p.

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Regeneron wins bid to buy 23andMe out of bankruptcy

BioPharma Drive: Drug Pricing

The biotech, which has for years invested in genetics research, plans to acquire "substantially all" of testing firm 23andMe's assets for $256 million.

Research 289
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Scientists discover class of crystals with properties that may prove revolutionary

Science Daily: Pharmacology News

Researchers have discovered a new class of materials -- called intercrystals -- with unique electronic properties that could power future technologies. Intercrystals exhibit newly discovered forms of electronic properties that could pave the way for advancements in more efficient electronic components, quantum computing and environmentally friendly materials, the scientists said.

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Discovery of a Novel Serine-Targeting Covalent Inhibitor against HCES2A for Treating Drug-induced Diarrhea and Ulcerative Colitis

Covalent Modifiers

Danyang Hu, Hairong Zeng, Wenxuan Li, Ya Zhang, Xiaoqian Chi, Xiaoyu Liu, Haijing Zhang, Guangbo Ge, Xiaozhen Jiao, and Ping Xie Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.5c00563 Mammalian carboxylesterases play an important role in the hydrolysis of both endogenous substrates and xenobiotics bearing ester or amide bond(s). We previously reported that bysspectin A and its derivative LC-20W were potent reversible hCES2A inhibitors.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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CDD Vault Update (May 2025): New PDB Viewer, AI Similarity Searches, Registered IDs in AI Results, Inventory Unit Conversion, Visualize Batch Data, Nucleotide to Amino Acid Sequence Translation

Collaborative Drug

CDD Vault Update (May 2025): New PDB Viewer, AI Similarity Searches, Registered IDs in AI Results, Inventory Unit Conversion, Visualize Batch Data, Nucleotide to Amino Acid Sequence Translation

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Roche strikes Orionis deal to develop ‘molecular glues’ for cancer

BioPharma Drive: Drug Pricing

The Swiss pharma has inked several collaborations in this field, suggesting it sees the approach as promising to rid the body of destructive proteins that are hard to target by other means.

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Not one, but two massive black holes are eating away at this galaxy

Science Daily: Pharmacology News

Astronomers searching for massive black holes shredding stars found one in an unusual place -- 2,600 light years from the core of a galaxy. The roque black hole may be from an earlier merger with another galaxy, or have been tossed out of the core after interacting with two other black holes. This is the first ever optically discovered off-nuclear tidal disruption event.

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Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30

Covalent Modifiers

Nafizul Haque Kazi, Nikolas Klink, Kai Gallant, Gian-Marvin Kipka & Malte Gersch Nat Struct Mol Biol , 2025 [link] The mitochondrial deubiquitinase ubiquitin-specific protease (USP) 30 negatively regulates PINK1parkin-driven mitophagy. Whether enhanced mitochondrial quality control through inhibition of USP30 can protect dopaminergic neurons is currently being explored in a clinical trial for Parkinsons disease.

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AI-Powered Portfolio Management in Pharmaceuticals

Drug Patent Watch

"Revolutionizing the Pharmaceutical Industry: How AI-Powered Portfolio Management is Changing the Game As the pharmaceutical landscape continues to evolve, companies are under increasing pressure to optimize their portfolios and stay ahead of the competition. But with the average cost of bringing a new drug to market soaring to over $2 billion, the stakes have never been higher.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Florida-Grown Cucumbers Behind Salmonella Outbreak, CDC Warns

Drugs.com

WEDNESDAY, May 21, 2025 Health officials are investigating a salmonella outbreak tied to cucumbers grown in Florida. At least 26 people across 15 states have gotten sick, and nine people have been hospitalized, the U.S. Food and Drug A.

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FDA OKs first blood test to aid Alzheimer’s diagnosis

BioPharma Drive: Drug Pricing

The FDA cleared the test for early detection of amyloid plaques associated with Alzheimer’s in people aged 55 years and older with signs and symptoms of the disease.

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A new technology for extending the shelf life of produce

Science Daily: Pharmacology News

Researchers developed a way to extend the shelf life of vegetables by injecting them with melatonin using biodegradable microneedles.

Research 259
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With AI, researchers predict the location of virtually any protein within a human cell

Broad Institute

With AI, researchers predict the location of virtually any protein within a human cell By Corie Lok May 19, 2025 Breadcrumb Home With AI, researchers predict the location of virtually any protein within a human cell Trained with a joint understanding of protein and cell behavior, the model could help with diagnosing disease and developing new drugs.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Tofersen

New Drug Approvals

all-P-ambo -2′- O -(2-Methoxyethyl)-5-methyl- P -thiocytidylyl-(3’5′)-2′- O -(2-methoxyethyl)adenylyl-(3’5′)-2′- O -(2-methoxyethyl)- P -thioguanylyl-(3’5′)-2′- O -(2-methoxyethyl)guanylyl-(3’5′)-2′- O -(2-methoxyethyl)- P -thioadenylyl-(3’5′)- P -thiothymidylyl-(3’5′)-2′-deoxy- P -thioadenylyl-(3’5′)-2′-deoxy-5-methyl- P -thiocytidylyl-(3’5′)-2′-deoxy-

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FDA Launches Postmarket Chemical Review Program to Ensure Food Safety

Drugs.com

MONDAY, May 19, 2025 -- Last week, the U.S. Food and Drug Administration announced a move to improve transparency and strengthen the safety of chemicals used in the nation's food supply.The agency is implementing an enhanced review process for food.

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Reproductive health startup raises $65M for infertility drugs

BioPharma Drive: Drug Pricing

Founded in 2021, ReproNovo has licensed rights to two drugs from Mereo BioPharma and ObsEva that it thinks could address fertility issues in men and women.

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Capuchin monkeys develop bizarre 'fad' of abducting baby howlers

Science Daily: Pharmacology News

Animal abduction: Biologists documented five male capuchin monkeys carrying at least eleven different infant howler monkeys -- a behavior never before seen in wild primates. Rise and spread: The sightings were remotely recorded by over 85 camera traps, which allowed scientists to pinpoint the origin and subsequent spread of this social tradition over a 15-month period.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Scientists create next generation of tools in battle against brain disease

Broad Institute

Scientists create next generation of tools in battle against brain disease By Corie Lok May 21, 2025 Breadcrumb Home Scientists create next generation of tools in battle against brain disease The findings contained in eight studies could lead to targeted gene therapies for brain disorders. By Allen Institute May 21, 2025 Credit: Allen Institute Different populations of cells in the mouse brain, each one targeted with high specificity by one of the many new genetic tools developed by scientists a

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Information Flow In Growing Organizations: A Framework For Results

LifeSciVC

By Ankit Mahadevia, former CEO of Spero Therapeutics and Atlas alumni, as part of the From The Trenches of LifeSciVC I recently read Yuval Noah Hariris Nexus ; what stuck with me was how a society uses information to create shared meaning can have a profound impact on peoples experiences. Hariri employs this lens to illustrate the significant differences between living in Moscow versus Michigan in the 1980s and Beijing versus Boston today.

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Blood, Urine Tests Can Identify Level Of Ultra-Processed Food In Diet

Drugs.com

WEDNESDAY, May 21, 2025 Worried youre scarfing down too many ultra-processed foods?Blood and urine tests might be able to reveal how much of your diet is made up of industrially produced foods, a new study says.Chemicals produced as the body con.

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From insight to impact: How eCOAs strengthen trial data quality

BioPharma Drive: Drug Pricing

Timely, high-integrity insights for sponsors that reduce risk and move trials forward.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Could nanoplastics in the environment turn E. coli into a bigger villain?

Science Daily: Pharmacology News

Nanoplastics are everywhere. These fragments are so tiny they can accumulate on bacteria and be taken up by plant roots; they're in our food, our water, and our bodies. Scientists don't know the full extent of their impacts on our health, but new research suggests certain nanoplastics may make foodborne pathogens more virulent.

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Genomic score predicts patients' progression to multiple myeloma

Broad Institute

Genomic score predicts patients' progression to multiple myeloma By Tom Ulrich May 21, 2025 Breadcrumb Home Genomic score predicts patients' progression to multiple myeloma Mutation-based score provides a personalized indicator of disease severity and progression risk, could help inform early intervention strategies By Elizabeth Dougherty, Dana-Farber Cancer Institute May 21, 2025 Credit: NCI Visuals Online Multiple myeloma tumor cells (green) Related people Gad Getz Related programs Cancer Prog

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POLB 001: tackling cytokine storms before they start

Drug Target Review

In the ever-evolving landscape of immuno-oncology, managing the side effects of advanced therapies has become just as important as enhancing their efficacy. Among the most concerning complications is cytokine release syndrome (CRS), a potentially life-threatening condition that frequently follows the administration of some CAR T-cell therapies and bispecific antibodies.

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Former President Joe Biden Diagnosed With Aggressive Prostate Cancer

Drugs.com

MONDAY, May 19, 2025 Former President Joe Biden has been diagnosed with advanced prostate cancer that has spread to his bones, his office announced Sunday.Doctors found the cancer after Biden reported urinary symptoms. Testing showed a small n.

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Bridging the data gaps that impact retail and specialty-lite success

BioPharma Drive: Drug Pricing

Learn how to leverage predictive analytics and measure top KPIs to maximize patient outcomes, provider engagement and brand performance on this webinar from PHIL and Syneos Health.

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Astronomers observe largest ever sample of galaxies up to over 12 billion light years away

Science Daily: Pharmacology News

The largest sample of galaxy groups ever detected has been presented by a team of international astronomers using data from the James Webb Space telescope (JWST) in an area of the sky called COSMOS Web. The study marks a major milestone in extragalactic astronomy, providing unprecedented insights into the formation and evolution of galaxies and the large-scale structure of the universe.

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New study aims to uncover the genetics of anorexia and other eating disorders

Broad Institute

New study aims to uncover the genetics of anorexia and other eating disorders By Allessandra DiCorato May 19, 2025 Breadcrumb Home New study aims to uncover the genetics of anorexia and other eating disorders Scientists are recruiting volunteers with eating disorders to study their DNA and look for genetic factors that could point towards new treatments.

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Transforming biotherapeutics delivery for local communities

Drug Target Review

In an era where biotherapeutics are transforming the healthcare landscape, the organisation, Vitalant , is uniquely positioned to bridge the gap between cutting-edge therapies and community access. With decades of expertise and a deeply rooted presence in healthcare networks across the country, Vitalant is not just supporting the rise of novel therapies, its actively enabling them.