BioPharma Drive: Drug Pricing
JUNE 5, 2025
A deal worth up to $712 million with the China-based biotech gives Cullinan T cell engagers aimed at BCMA and CD19, two targets of interest in inflammatory conditions.
Drugs.com
JUNE 6, 2025
FRIDAY, June 6, 2025 — Immunotherapy combined with chemo can give people a fighting chance against stomach and esophageal cancers, a new clinical trial says.People treated with durvalumab and chemotherapy were much more likely to go into remission.
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Drugs.com
JUNE 3, 2025
TUESDAY, June 3, 2025 -- The U.S. Food and Drug Administration has approved a new lower-dose vaccine for active immunization against COVID-19 caused by severe acute respiratory syndrome coronavirus 2. The new vaccine (mNexspike [COVID-19 Vaccine.
Science Daily: Pharmacology News
JUNE 3, 2025
Researchers asked patients, some of whom had experienced lower back pain for up to 40 years, if being in nature helped them coped better with their lower back pain. They found that people able to spend time in their own gardens saw some health and wellbeing benefits. However, those able to immerse themselves in larger green spaces such as forests felt even more positive, as they were able to lose themselves in the environment and focus more on that than their pain levels.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Covalent Modifiers
JUNE 5, 2025
Gibae Kim, R. Justin Grams, and Ku-Lung Hsu Chemical Reviews 2025 DOI: 10.1021/acs.chemrev.5c00001 Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional drug design. Covalent chemistry has emerged as a powerful solution for accessing protein sites in difficult to ligand regions.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
JUNE 4, 2025
WEDNESDAY, June 4, 2025 Pepto Bismol is a go-to stomach remedy, but a new study suggests it might not help prevent diarrhea during international travel.The study, led by the U.S. Centers for Disease Control and Prevention (CDC), found that people.
BioPharma Drive: Drug Pricing
JUNE 6, 2025
Late-stage results Otsuka presented in IgA nephropathy triggered a sell-off in Vera shares. Elsewhere, investors scrutinized Regenxbio’s Duchenne data and a brain drug study failed.
Science Daily: Pharmacology News
JUNE 3, 2025
New research has found that those who consume a diverse range of foods rich in flavonoids, such as tea, berries, dark chocolate, and apples, could lower their risk of developing serious health conditions and have the potential to live longer.
Covalent Modifiers
JUNE 9, 2025
Charlotte M. Zammit, Cory M. Nadel, Ying Lin, Sajjan Koirala, Elnaz Ahani, Patrick Ryan Potts, and Daniel K. Nomura Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.5c02801 Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or the expression of truncated variants of AR that are constitutively activated.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Chemical Biology and Drug Design
JUNE 9, 2025
A series of small molecule PD-L1 inhibitors was discovered via optimization of the solvent-interaction region. GJ19 showed the most potent anti-PD-L1 effects with an IC 50 of 32.06 nM. GJ19 (i.p., 15 mg/kg) effectively suppressed tumor growth with a TGI of 56.8% in a B16-F10 melanoma mouse model. ABSTRACT Despite extensive research, the topic of anti-PD-L1 small-molecule inhibitors remains elusive.
Drugs.com
JUNE 4, 2025
WEDNESDAY, June 4, 2025 A morning cup of coffee might do more than momentarily boost your energy and spirits.Full-test java also appears to help women age more gracefully, a new study says.Middle-aged women who regularly drank caffeinated coffee w.
BioPharma Drive: Drug Pricing
JUNE 4, 2025
Enhertu, Datroway and other antibody-drug conjugates developed by Daiichi Sankyo have made the company a leader in a competitive field. Hiroyuki Okuzawa is working to keep it that way.
Science Daily: Pharmacology News
JUNE 3, 2025
Astronomers have revealed new research showing that millions of new solar system objects are likely to be detected by a brand-new facility, which is expected to come online later this year.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Target Review
JUNE 6, 2025
In recent years, the field of nuclear medicine has undergone a quiet revolution, particularly in its application to oncology. At the forefront of this transformation is Dr Ebrahim Delpassand, a nuclear medicine physician and the driving force behind RadioMedix (RMX), a radiopharmaceutical company focused on developing targeted diagnostics and therapies.
Chemical Biology and Drug Design
JUNE 9, 2025
Erianin suppresses ox-LDL-induced apoptosis and oxidative stress by regulating Nrf2 signaling in HUVECs. ABSTRACT Oxidized low-density lipoprotein (ox-LDL)-induced endothelial cell damage plays an important role in the pathogenesis of atherosclerosis (AS). This study aimed to investigate the ability of Erianin to protect human umbilical vein endothelial cells (HUVECs) against ox-LDL-induced oxidative stress and its underlying mechanisms.
Drugs.com
JUNE 4, 2025
WEDNESDAY, June 4, 2025 Troubled children and teenagers are languishing hours in chaotic hospital emergency rooms, waiting for a psychiatric bed to open, a new study says.About 1 in 3 kids who go to an emergency room (ER) amid a mental health c.
BioPharma Drive: Drug Pricing
JUNE 4, 2025
The company is one of the first to receive a “platform technology designation,” which could speed the review of certain gene therapy applications it later brings to the regulator.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
JUNE 10, 2025
Acetaminophen may be doing more than just dulling pain in your brain it could be stopping it before it even starts. Scientists at Hebrew University have discovered that a metabolite of the drug, AM404, blocks pain signals right at their source by shutting down specific sodium channels in pain-sensing nerves. This radically shifts our understanding of how this common medication works and opens a door to new, more targeted painkillers that might eliminate side effects like numbness or weakness.
Collaborative Drug
JUNE 5, 2025
A practical guide to selecting the right ELN or LIMS for early-stage drug discovery, focusing on usability, structure search, and scalability.
Chemical Biology and Drug Design
JUNE 9, 2025
The overall mechanism diagram of ferulic acid delaying renal interstitial fibrosis and inhibiting incomplete EMT of TECs by regulating HIF-1α. ABSTRACT Ferulic acid (FA), a natural phenolic compound, shows potential therapeutic effects on renal interstitial fibrosis, although its antifibrotic mechanism remains unclear. This study investigated the molecular mechanisms of FA by focusing on epithelial-mesenchymal transition (EMT) and related signaling pathways.
BioPharma Drive: Drug Pricing
JUNE 4, 2025
Breast cancer study results impressed at this year’s meeting, but raised new questions. Doctors also wrestled with how best to use new bispecific antibodies, and expressed concern about looming cuts to science funding.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
JUNE 5, 2025
Harvard and PSI scientists have managed to freeze normally fleeting quantum states in time, creating a pathway to control them using pure electronic tricks and laser precision.
Drug Target Review
JUNE 6, 2025
As antibody-drug conjugates (ADCs) gain traction across oncology and begin to expand into other therapeutic areas, a persistent challenge remains: the design and optimisation of payloads. Across Sygnature Discovery , multidisciplinary teams in Canada and the UK are actively working to address these challenges. With an extensive background in small molecule chemistry, bioconjugation and protein science, these expert teams are leading efforts to place payload development at the centre of ADC innov
Chemical Biology and Drug Design
JUNE 9, 2025
Glutamine reduces WTAP expression and thus upregulates NCOA3 by suppressing WTAP-mediated m6A modification of NCOA3 mRNA, thereby exerting protective activity in ulcerative colitis (UC). ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory condition. Glutamine (Gln) has shown an improved effect on UC. However, its molecular determinants are incompletely understood.
Drugs.com
JUNE 6, 2025
FRIDAY, June 6, 2025 — A repurposed diabetes drug can be an effective tool against fatty liver disease, a new clinical trial has found.Dapagliflozin helped people reduce fat levels in their liver and avoid liver scarring that comes with the c.
BioPharma Drive: Drug Pricing
JUNE 3, 2025
Elinzanetant proved effective for managing disruptive vasomotor symptoms in women on endocrine therapy, supporting a Bayer application for approval.
Science Daily: Pharmacology News
JUNE 6, 2025
Scientists have discovered that a molecule known for defending animal immune systems called itaconate also plays a powerful role in plants. Researchers showed that itaconate not only exists in plant cells but actively stimulates growth, such as making corn seedlings grow taller. This surprising crossover between plant and animal biology may unlock new, natural ways to boost agriculture and even improve human health.
Drug Target Review
JUNE 9, 2025
The landscape of genetic medicine is undergoing a profound transformation, driven by innovative approaches that challenge the traditional, disease-specific paradigms. One company leading the charge in this revolution is Alltrna , whose pioneering work in engineered transfer RNA (tRNA) therapeutics is offering new hope for patients with rare genetic diseases.
Alta Sciences
JUNE 6, 2025
Case Study: Two Examples of Successful Automation Integration at Altasciences for Pharmacokinetic Studies pmjackson Fri, 06/06/2025 - 09:01 By Martin Rougée, Optimization Scientist, Bioanalytical Operations Automation offers several advantages to any industry. For a contract research organization (CRO), it can play an integral role in increasing the quality and speed of drug development while reducing costs, repetitive manual tasks, and human error.
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