Codon

DECEMBER 10, 2023

A zoologist, ecologist, and protein engineer all call themselves “biologists,” but rarely attend the same conferences. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors).

Protein Expression 90

Protein Expression Laboratories DNA Engineering 90

DrugBank

OCTOBER 17, 2024

Data Science in Lead Optimization and Drug Design Data science accelerates the lead optimization and drug design process, transforming how molecules are engineered for therapeutic applications. These complex molecules require precise engineering to ensure optimal efficacy and safety.

Drug Development 98

Drug Development Metabolic Stability Clinical Trials Drugs 98

Perficient: Drug Development

APRIL 28, 2025

The Illusion of Data-Driven Greatness Some time back , I was working on a project where a major trading platform launched a new engine to automate trade surveillance and compliance monitoring. The organization had to suspend the AI engine and return to manual reviews in parallel, a massive operational setback. Dollars were invested.

Government 59

Government Compliance Engineering DNA 59

Drug Target Review

JULY 31, 2023

For my PhD project, I chose an advisor who worked on DNA and I started working with her on the physical properties of DNA. I worked with Jackie Barton in the early days of what’s now called DNA-mediated electron transfer. I went to Genentech and postdoc-ed for Jim Wells in protein engineering.

DNA 98

DNA Small Molecule Science Cell Biology 98

The Pharma Data

JANUARY 31, 2021

(NASDAQ: ILMN), the global leader in DNA sequencing and array-based technologies, and Sequoia Capital China , a leading investment firm, today announced a collaboration to catalyze the startup ecosystem in China with the launch of the Sequoia Capital China Intelligent Healthcare Genomics Incubator, Powered by Illumina.

DNA 52

DNA Engineering Science Marketing 52

Broad Institute

JULY 11, 2024

Drugs that block mutated IDH1 (mIDH1) have recently come onto the market and effectively slow tumor growth, but the exact mechanism at work to stall tumors is still unclear. Reporting in Science , researchers at Massachusetts General Hospital and the Broad Institute of MIT and Harvard have made a surprising discovery about these drugs.

Treatment 72

Treatment Immune Response Drugs Virus 72

The Pharma Data

SEPTEMBER 11, 2021

By leveraging our unique ability to manufacture DNA at scale, we can construct proprietary antibody libraries precisely designed to match sequences that occur in the human body. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip.

DNA 52

DNA Bioinformatics Production Engineering 52

Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Dr Chelsea B Pratt is the Biopharma Segment Marketing Manager at Bio-Rad Laboratories.

Therapies 52

Therapies Virus DNA Compliance 52

The Open Targets Blog

APRIL 25, 2023

Although the estate was undoubtedly pretty, the Hall had seen better days and was rather dominated by a 1950s building that provided laboratories for the light engineering company that had owned the site. ranging from university academics through engineers and clerical staff to the military. The same went for analysis tools.

DNA 52

DNA Government Engineering Laboratories 52

The Pharma Data

DECEMBER 14, 2020

The global GBM treatment market is projected to reach $3.3 representing the largest market. engine along with algorithms tuned to predict BBB permeability played an important role in helping determine which CNS cancers and which genomically-defined subtypes of CNS cancer should be prioritized for development. .

Clinical Trials 52

Clinical Trials DNA Drugs Therapies 52

The Pharma Data

OCTOBER 19, 2020

The company’s suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions. Europe , Asia and other international markets. Caris provides services throughout the U.S.,

Clinical Trials 52

Clinical Trials RNA DNA Science 52

Alta Sciences

APRIL 17, 2024

Several viral vectors are being used currently, in addition to non-viral vectors, such as oligonucleotides, naked DNA, and lipoplexes and polyplexes. Fifteen oligonucleotides have so far received market authorization in different countries, and several others are being test in clinical Phase I to III trials. Asia, and Europe.

Drug Development 52

Drug Development Treatment Drugs FDA Approval 52

Nvidia Developer: Drug Discovery

MARCH 21, 2023

Creating new drug candidates is a heroic endeavor, often taking over 10 years to bring a drug to market. Creating new drug candidates is a heroic endeavor, often taking over 10 years to bring a drug to market. New supercomputing-scale large language models (LLMs).

Small Molecule 52

Small Molecule Drugs Clinical Trials DNA 52

The Pharma Data

NOVEMBER 27, 2020

The PRV can be redeemed to receive priority review for any subsequent marketing application or sold or transferred to other companies for their programs. With this approval, the FDA issued a Rare Pediatric Disease Priority Review Voucher (PRV) to Rhythm.

FDA Approval 52

FDA Approval FDA Clinical Trials Therapies 52

Agency IQ

APRIL 12, 2024

Additionally, six of these comments came from the same organization (Integrated DNA Technologies). The International Society for Pharmaceutical Engineering (ISPE) took a more nuanced approach, requesting that the language be tweaked to indicate that multiple assays are often optional. Should potency assurance plans be submitted?

Production 40

Production FDA Therapies Biochemical Assays 40

Codon

APRIL 14, 2025

In the four years I’ve been working as a machine learning engineer at Dyno Therapeutics , a biotechnology company in Boston, I’ve become increasingly convinced that biologists have an almost masochistic tolerance for difficult and protracted work. Many CROs operate in small, captive markets with high switching costs.

Protein Expression 90

Protein Expression Engineering Research RNA 90

Codon

JULY 17, 2024

He’s an educator, molecular florist, and founder at Binomica Labs , a small biology research group focusing on providing an alternative to “exposure-driven and marketing-centric research.” Years later, when I attended university, I stumbled upon plant genetic engineering. It changed my entire perspective on flowers.

Laboratories 107

Laboratories Engineering Molecular Biology Science 107

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. The limitations of natural AAV serotypes in meeting all clinical needs has spurred growing interest in AI-driven AAV engineering approaches. His mentorship produced numerous publications.

Engineering 105

Engineering Virus Therapies Immune Response 105

Codon

FEBRUARY 13, 2024

Some algorithms simply look for important similarities between phage and bacterial DNA sequences, a signal of the extensive gene-swapping that goes on when a particular virus and bacteria have shared history. Middle and Right) Once a bacteriophage lands on a cell, it injects its DNA through a tube (purple) into the unwilling host.

Therapies 136

Therapies Virus DNA Clinical Trials 136

Codon

JUNE 2, 2025

The inheritors of such a worldview, the artist-researchers of The Tissue Culture and Art Project began exploring the artistic applications of tissue engineering in 1996. They saw their mission as “a pioneering collaboration that explores how tissue engineering can be used as a medium for artistic expression.”

Engineering 64

Engineering Therapies DNA Trials 64

PLOS: DNA Science

JUNE 13, 2024

Through graphics and five main points, Chan countered the wet market scenario of the pandemic’s beginnings. Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. c) in a “wet market?”

Virus 52

Virus RNA DNA Science 52

Codon

APRIL 19, 2023

To combat these threats, genetic engineers are making bananas that fend off fungi or ripen slower than natural varieties. In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening.

DNA 52

DNA RNA Engineering Regulations 52

Codon

APRIL 19, 2023

To combat these threats, genetic engineers are making bananas that fend off fungi or ripen slower than natural varieties. In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening.

DNA 52

DNA RNA Engineering Regulations 52

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer. But now, their engineered brethren can live about 82 percent longer. Engineered yeast live longer than their “normal” brethren. From Zhang et al.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer. But now, their engineered brethren can live about 82 percent longer. Engineered yeast live longer than their “normal” brethren. From Zhang et al.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

MARCH 20, 2023

🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Biological Engineering Generation of functional oocytes from male mice in vitro. Marine biofilm engineered to produce current in response to small molecules. Marine biofilm engineered to produce current in response to small molecules.

Virus 52

Virus RNA Engineering Small Molecule 52

Drug Target Review

APRIL 16, 2024

By delivering radiation directly to the tumour cells, RLT can induce DNA damage, leading to cell death and tumour regression. Key advantages of mAbs over peptides and small molecules are: High Specificity: mAbs can be engineered to bind specifically to a particular target antigen with high affinity.

Small Molecule 59

Small Molecule Therapies Treatment Pharmaceutical Companies 59

The Pharma Data

AUGUST 3, 2021

. – Second-quarter 2021 operating expenses increased 18 percent, driven primarily by higher research and development investments for late-stage assets, as well as higher relative marketing and selling expenses due to pandemic-related spending reductions in 2020. – Second-quarter 2021 earnings per share (EPS) decreased to $1.53

Production 52

Production Marketing Research Government 52

PLOS: DNA Science

SEPTEMBER 21, 2023

I interviewed him for Genetic Engineering News , where I covered gene amplification – a field that began with Mullis’s PCR. What steps should researchers take when attempting to acquire DNA samples from modern descendants? The post The Festival of Genomics and Biodata 2023 Comes to Boston appeared first on DNA Science.

DNA 52

DNA Science Medical Schools Government 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

Therapies 52

Therapies RNA DNA Engineering 52

PLOS: DNA Science

OCTOBER 12, 2023

In addition to high cost and small markets, patient responses haven’t been predictable. million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. appeared first on DNA Science. The implicated gene is the largest in a human genome, with 2.2

Therapies 69

Therapies Immune Response DNA Virus 69

DrugBank

FEBRUARY 26, 2025

Targeting Novel Bacterial Pathways Traditional antibiotics often target essential bacterial processes such as cell wall synthesis or DNA replication. Advances in genetic engineering have enabled researchers to enhance bacteriophage efficacy and overcome bacterial resistance mechanisms.

Therapies 52

Therapies Pharmaceutical Companies Pharmacokinetics Treatment 52

Codon

MARCH 24, 2024

Novo Nordisk’s market capitalization ($442B) is already larger than the GDP of Denmark ( $404B ), the country where the company is headquartered. The market for semaglutide-based products is projected to swell to $71B in less than a decade. market with Wegovy will, by 2030, require about one million liters of production capacity.

Engineering 87

Engineering Vaccine Production RNA 87

Codon

NOVEMBER 1, 2024

For example, cloning DNA molecules and inserting them into cells — a process required for basically all experiments in molecular biology — takes up to a week of work. Perhaps you’ve seen this chart before, which shows the falling costs of DNA sequencing over the last two decades. If we could get E.

DNA 130

DNA RNA Molecular Biology Laboratories 130

Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. Collections of mRNA have been understood as a proxy for cell states for decades. Subscribe to Asimov Press.

Engineering 144

Engineering Virus DNA Therapies 144

Codon

APRIL 9, 2023

LanzaTech announced a partnership with H&M Move to convert factory carbon emissions into fabrics using engineered microbes. Sponge cells double in population quite quickly — around 40 minutes — and could be engineered to manufacture drugs. Read Biological Engineering *Self-healable spider dragline silk materials.

Therapies 52

Therapies RNA Engineering Vaccine 52