DNA Engineering Packaging 
Broad Institute
JANUARY 14, 2025
The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. In 2018, Liu, who works on the same floor as Minikel and Vallabh at Broad, approached them and proposed a collaboration.
Broad Institute
JUNE 24, 2025
Related groups Liu Group Related news New CRISPR genome editing system offers a wide range of versatility in human cells Researchers extend power of gene editing by developing a new class of DNA base editors In May 2025, researchers announced that K.J. Some of these treatments, like K.J.’s, He needed a personalized, one-of-a-kind therapy.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Codon
JULY 28, 2025
A gene is the essential hereditary unit that passes traits from parents to offspring; a segment of DNA containing instructions for making a specific protein or molecule that performs a particular function in your body. As methods for resolving errors in DNA continue to advance, it has never been easier to fix a broken gene.
Codon
JUNE 5, 2025
Certain CRISPR components can add short DNA sequences from the genomes of defeated viruses into the bacterium’s own genome, creating a type of protective “memory.” If the same virus invades the cell a second time, the gRNA’s spacer sequence will bind to the matching viral DNA sequence, then be cut by the Cas protein.
Codon
NOVEMBER 1, 2024
For example, cloning DNA molecules and inserting them into cells — a process required for basically all experiments in molecular biology — takes up to a week of work. Perhaps you’ve seen this chart before, which shows the falling costs of DNA sequencing over the last two decades. If we could get E.
Codon
JULY 31, 2025
If the electrical gradient gradually disappears during an infection, less and less ATP will be available for energy-hungry steps in the phage lifecycle, such as DNA replication or packaging the genome into capsids. That randomness would make it impossible to tell exactly when lysis occurred, or what caused it.
Broad Institute
JANUARY 8, 2024
A team of researchers at the Broad Institute of MIT and Harvard has engineered virus-like particles to deliver prime editors to cells in mice at a high enough efficiency to rescue a genetic disorder. Prime editing, described in 2019 by Liu’s group, can make longer and more diverse types of DNA changes than other types of editing.
Expert insights. Personalized for you.
Let's personalize your content