Broad Institute

MARCH 14, 2024

Scientists generate new targeted protein degradation system that tunes a cell’s own proteins By Leah Eisenstadt March 14, 2024 Breadcrumb Home Scientists generate new targeted protein degradation system that tunes a cell’s own proteins Researchers have engineered a compact degron tag that can be precisely edited into a cell’s genome, enabling scientists to trigger the rapid breakdown of native target proteins.

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Targeted Protein Degradation Small Molecule Medical Schools Science 141

Science Daily: Pharmacology News

MARCH 13, 2024

An unassuming brown bovine from the south of Brazil has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes.

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BioPharma Drive: Drug Pricing

MARCH 14, 2024

Rezdiffra’s clearance is a turning point in the fight against the liver disease. But its sales potential is unclear, and competition could emerge from popular weight loss drugs.

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FDA Approval FDA Drugs Disease 130

Antidote

MARCH 12, 2024

For many people, participating in a research study presents an interesting opportunity with many benefits to volunteering. While there are many types of clinical research, all with distinct goals and timelines, trial volunteers will follow a similar path when taking part. Read on to learn more about the process.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- The blockbuster weight-loss medication Zepbound (tirzepatide) appears to help folks quickly shed pounds regardless of how overweight they are, or how long they've lived being overweight or obese. Those are the findings.

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Science Daily: Pharmacology News

MARCH 14, 2024

A healthier diet is associated with a reduced dementia risk and slower pace of aging, according to a new study. The findings show that a diet-dementia association was at least partially facilitated by multi-system processes of aging. Until now, the biological mechanism of this protection was not well understood.

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Antidote

MARCH 14, 2024

Receiving a multiple sclerosis (MS) diagnosis can feel overwhelming and isolating for many. MS is a neurodegenerative disease that often involves challenging symptoms — but knowing what to expect and what resources are available can help.

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Disease 116

Drugs.com

MARCH 12, 2024

TUESDAY, March 12, 2024 -- Women who've gone through menopause and hope that supplemental vitamin D plus calcium might shield them from disease may be disappointed by new data.A follow-up analysis of data from the landmark Women's Health Initiative.

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Disease 116

Science Daily: Pharmacology News

MARCH 13, 2024

Soil stores 80 percent of carbon on earth, yet with increasing cycles of drought, that crucial reservoir is cracking and breaking down, releasing even more greenhouse gases creating an amplified feedback loop that could accelerate climate change.

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BioPharma Drive: Drug Pricing

MARCH 15, 2024

The company expects initial uptake of Rezdiffra, which costs $47,400 per year, to be slow as doctors and insurers establish the protocols needed to find patients eligible for treatment.

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Clinical Trials

Drug Target Review

MARCH 11, 2024

A collaboration between the University of Twente in the Netherlands and Rousselot has revealed the dynamics between biomaterial purity and the fidelity of 3D cancer models. Their joint study illuminated the profound impact of endotoxins on the accuracy and efficacy of these models, marking a significant breakthrough in cancer research. Through experimentation, contrasting research-grade gelatine, inherently infused with endotoxins, with an ultra-low endotoxin-level gelatine, they revealed that t

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Perficient: Drug Development

MARCH 14, 2024

Last week, I attended TrailblazerDX in San Francisco, where the content was all about Salesforce Data Cloud and AI! There were over 300 sessions to attend, from technical talks to hands-on workshops where attendees could learn how to build copilots and how to use the latest Salesforce platform features directly from product managers , architects, and fellow developers.

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Science Daily: Pharmacology News

MARCH 14, 2024

Inspired by the classic drinking bird toy, scientists have developed an engine that efficiently converts energy from water evaporation into electricity to power small electronics. The device produces energy outputs exceeding 100 volts -- much higher than other techniques that generate electricity from water -- and can operate for several days using only 100 milliliters of water as fuel, according to a new study.

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BioPharma Drive: Drug Pricing

MARCH 12, 2024

Physicians are preparing for tough conversations with patients on Amylyx Pharmaceuticals’ drug, Relyvrio, while holding out hope it still may help some with the disease.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Target Review

MARCH 12, 2024

Scientists from the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have discovered thousands of bile acids. The study’s findings offer new insights into the biochemical language microbes use to influence distant organ systems, which could revolutionise the way researchers approach disease. Dr Pieter Dorrestein, senior author, professor at the Skaggs School and professor of pharmacology and paediatrics at UC San Diego School of Medicine, stated: “B

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Disease Biochemical Pharmacology FDA Approval Pharmacy 111

KIF1A

MARCH 9, 2024

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. Meet our Guest Bloggers! This spring we’ve been quite fortunate to be joined by 6 Master’s students from Columbia University, who have been contributing to our creation of community resources as part of the

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Laboratories Science Research Disease 111

Science Daily: Pharmacology News

MARCH 12, 2024

A large find of dinosaur tracks and fossilized plants and tree stumps in far northwestern Alaska provides new information about the climate and movement of animals near the time when they began traveling between the Asian and North American continents roughly 100 million years ago.

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MARCH 14, 2024

The funding for the startup, which partnered with Bristol Myers Squibb last year, adds to a surge of recent investments in developers of antibody-drug conjugates.

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Drugs.com

MARCH 11, 2024

MONDAY, March 11, 2024 -- Following disappointing trial results, the maker of a controversial ALS drug may pull the medication off the market. In a statement issued Friday, Amylyx Pharmaceuticals said that Relyvrio failed to help patients in a.

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Drug Target Review

MARCH 15, 2024

The discovery and development phases of biotherapeutic drugs leverage multiple technologies and processes across upstream and downstream stages of the bioprocess workflow. Advancements in cell line development (CLD), including screening and selection of final clones, scale up, automation and digitalisation have enabled precision and enhanced productivity.

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Science Daily: Pharmacology News

MARCH 14, 2024

Materials that are incredibly thin, only a few atoms thick, exhibit unique properties that make them appealing for energy storage, catalysis and water purification. Researchers have now developed a method that enables the synthesis of hundreds of new 2D materials.

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BioPharma Drive: Drug Pricing

MARCH 11, 2024

Justin Klee and Joshua Cohen spoke to BioPharma Dive about the next steps for their company, which is considering pulling its only product from market after the drug failed a confirmatory study in ALS.

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Drugs.com

MARCH 13, 2024

WEDNESDAY, March 13, 2024 — Nurses who specialize in anesthesia have issued new guidelines to reduce the risk that patients taking weight-loss drugs like Ozempic or Wegovy throw up during surgery."These medications have exploded in.

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Perficient: Drug Development

MARCH 12, 2024

One common way of implementing tags through Adobe Launch is using a data layer, which is a JSON object (key/value pair) that is loaded onto the page from which attributes are passed through as the user navigates through the website or completes certain objectives. This can be extended further into using an Event-Driven Data Layer (EDDL), which serves to load Custom Events within JavaScript that are passed to the data layer upon an action being completed on the website, and can be loaded on any e

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Science Daily: Pharmacology News

MARCH 13, 2024

Global GDP loss from climate change will increase exponentially the warmer the planet gets when its cascading impact on global supply chains is factored in, finds a new study.

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BioPharma Drive: Drug Pricing

MARCH 14, 2024

Pressed by lawmakers, the lobbying group is also “taking steps” to end its relationship with Wuxi-AppTec, a major contract manufacturer to the biopharmaceutical industry.

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Drugs.com

MARCH 12, 2024

TUESDAY, March 12, 2024 -- They're cheap, easy to buy and now new research shows they have become the buzz of choice for American teens. Delta-8-THC products, which include gummies and vapes, are legal in 22 states and Washington, D.C. There is no.

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Perficient: Drug Development

MARCH 11, 2024

AI (Artificial Intelligence) Powered Product People Have you ever wondered how artificial intelligence can transform not only our lives but also our professions? As someone passionate about technology and digital product development, I have always been intrigued by new tools and how they can improve our lives and careers. In recent times, artificial intelligence (AI) has captured my attention.

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Science Daily: Pharmacology News

MARCH 11, 2024

When you are trying to solve one of the biggest conundrums in cosmology, you should triple check your homework. The puzzle, called the 'Hubble Tension,' is that the current rate of the expansion of the universe is faster than what astronomers expect it to be, based on the universe's initial conditions and our present understanding of the universe's evolution.

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BioPharma Drive: Drug Pricing

MARCH 11, 2024

Sosei Heptares could receive more than 700 million euros in a deal to develop medicines aimed at the protein GPR52, an emerging drug target in multiple neurological diseases.

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Drugs.com

MARCH 12, 2024

TUESDAY, March 12, 2024 -- People diagnosed with attention-deficit hyperactivity disorder (ADHD) show a marked decline in their two-year risk for death once they start taking medication, new research shows. That was particularly true for deaths due.

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Perficient: Drug Development

MARCH 12, 2024

Perficient is excited to announce that we have earned the Government Specialization Distinction (Americas) in the new Pega Partners program. Specialized partners are thoroughly vetted by Pega to bring deep vertical knowledge or specialized expertise to clients. Pega Partners that achieve a Specialization have a demonstrated ability to help customers build more innovative businesses, and have a significant impact on their customers, stakeholders, and their partners.

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Science Daily: Pharmacology News

MARCH 13, 2024

Imagine performing a sweep around an object with your smartphone and getting a realistic, fully editable 3D model that you can view from any angle -- this is fast becoming reality, thanks to advances in AI. Researchers have unveiled new AI technology for doing exactly this. Soon, rather than merely taking 2D photos, everyday consumers will be able to take 3D captures of real-life objects and edit their shapes and appearance as they wish, just as easily as they would with regular 2D photos today.

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BioPharma Drive: Drug Pricing

MARCH 11, 2024

Roche said its experimental Alzheimer’s disease drug trontinemab showed it might be able to clear brain plaques faster than other medicines.

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