Sat.Mar 02, 2024 - Fri.Mar 08, 2024

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Antibody therapy shows anti-tumour activity in advanced cancer

Drug Discovery World

In an early phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumour activity in individuals with advanced cancer. Both medications tested in the trial support immune responses against tumour cells. CS1002 increases the activation and proliferation of T immune cells by binding to a T cell receptor called CTLA-4.

Therapies 289
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Early Impact Of The Inflation Reduction Act On Drug Discovery

Forbes: Drug Truths

There is another aspect of this provision of the IRA that is starting to be felt – "the small molecule penalty"

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FDA Warns of Toxic Lead in Cinnamon Products

Drugs.com

WEDNESDAY, March 6, 2024 -- The U.S. Food and Drug Administration issued a health advisory Wednesday warning consumers that six brands of ground cinnamon are tainted with lead. The FDA urged folks to throw away and not buy the following brands of.

FDA 145
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Amylyx ALS drug fails crucial study, putting company’s future in doubt

BioPharma Drive: Drug Pricing

The results have led Amylyx to pause promotion of Relyvrio and potentially pull it from the market in the coming weeks, a major blow to the company and ALS patients.

Marketing 137
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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AI reveals prostate cancer is not just one disease

Drug Discovery World

Research published in Cell Genomics has shown that prostate cancer includes two different subtypes of the disease, also known as evotypes. This discovery was made by using artificial intelligence (AI) to help unlock new discoveries about the evolution of prostate cancer which could lead to the development of new treatments. “Our research demonstrates that prostate tumours evolve along multiple pathways, leading to two distinct disease types,” said lead researcher Dr Dan Woodcock, of the Nuffield

Disease 147
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Does Federally Funded Research Justify A Piece Of Pharma’s Profits?

Forbes: Drug Truths

The thought that all drugs arise from government funded research is a fallacy.

Research 221

More Trending

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A smart molecule beats the mutation behind most pancreatic cancer

Science Daily: Pharmacology News

Researchers have designed a candidate drug that could help make pancreatic cancer, which is almost always fatal, a treatable, perhaps even curable, condition.

Research 134
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Akari Therapeutics and Peak Bio announce merger

Drug Discovery World

Biotechnology company Akari Therapeutics and biopharmaceutical company Peak Bio have announced a definitive agreement to merge as equals in an all-stock transaction. The combined entity will operate as Akari Therapeutics, which is expected to continue to be listed and trade on the Nasdaq Capital Market as AKTX. Following closing, the company will have an expanded pipeline that contains multiple assets spanning early and late development stages.

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FDA delays decision on Lilly’s closely watched Alzheimer’s drug

BioPharma Drive: Drug Pricing

The agency expects to convene a group of outside experts to more closely scrutinize the safety and efficacy of the medicine, donanemab, pushing back the timing of its potential approval.

FDA 121
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Carcinogen Benzene Can Form in Some Acne Treatments: Report

Drugs.com

THURSDAY, March 7, 2024 -- Some acne treatments may may banish blemishes but carry hidden dangers: A new report reveals high levels of the carcinogen benzene can form in products that contain the zit-fighting ingredient benzoyl peroxide.According.

Treatment 122
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Achieving New Heights in Healthcare Marketing With Salesforce Marketing Cloud Personalization

Perficient: Drug Development

In December 2022, the Department of Health and Human Services released a bulletin announcing additional compliance requirements for healthcare marketers when it comes to third-party trackers. The guidance lays forth expectations for how healthcare organizations collect data on activities that take place on their website and mobile apps. So, what’s the problem?

Marketing 122
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Sitting down with… Stefanie Dedeurwaerdere, UCB

Drug Discovery World

Stefanie Dedeurwaerdere is Global Strategy Lead for Pipeline Development in Global Epilepsy & Rare Syndromes at UCB. In her day-to-day role, she is responsible for the development of UCB’s epilepsy discovery strategy, working with researchers to advance understanding of epilepsies while ensuring candidates for a future clinical treatment pipeline to improve the lives of those living with the condition.

Treatment 147
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Lack of focus doesn't equal lack of intelligence -- it's proof of an intricate brain

Science Daily: Pharmacology News

Imagine a busy restaurant: dishes clattering, music playing, people talking loudly over one another. It's a wonder that anyone in that kind of environment can focus enough to have a conversation. A new study provides some of the most detailed insights yet into the brain mechanisms that help people pay attention amid such distraction, as well as what's happening when they can't focus.

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Co-founder of Company Behind Deadly 2012 Meningitis Outbreak Gets Up to 15 Years in Prison

Drugs.com

WEDNESDAY, March 6, 2024 -- Barry Cadden, co-founder of a specialty compounding pharmacy behind a deadly meningitis outbreak in 2012, has been handed a prison sentence of 10 to 15 years in Michigan for involuntary manslaughter.On Tuesday, Cadden.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Biden proposes strengthening Medicare’s drug pricing power

BioPharma Drive: Drug Pricing

The administration seeks to significantly increase the number of drugs each year that would be subjected to price negotiations under provisions of the Inflation Reduction Act.

Drugs 115
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Novel antibodies target ‘dark side’ of influenza virus protein

Drug Discovery World

Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored ‘dark side’ of the neuraminidase (NA) protein head. The antibodies target a region of the NA protein that is common among many influenza viruses, including H3N2 subtype viruses, and could be a new target for countermeasures.

Virus 147
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Sinking land increases risk for thousands of coastal residents by 2050

Science Daily: Pharmacology News

A new study provides a new comprehensive look at the potential for flooding in a combined 32 cities along the Atlantic, Pacific, and Gulf coasts. It predicts as many as 500,000 people will be affected by flooding alongside 1 in 35 privately owned properties within the next three decades, and it highlights the racial and socioeconomic demographics of those potentially affected.

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FDA Approves Wegovy to Help Prevent Heart Attack, Stroke

Drugs.com

FRIDAY, March 8, 2024 -- Wegovy (semaglutide), the weight-loss version of blockbuster diabetes drug Ozempic, was approved on Friday by the U.S. Food and Drug Administration to help prevent heart attack, stroke and heart death.“Wegovy is now the.

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Alnylam, Roche blood pressure drug scores in second mid-stage trial

BioPharma Drive: Drug Pricing

The study results further validate Roche’s recent decision to acquire rights to the drug, which is being developed for people with a stubborn form of hypertension.

Trials 119
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How improved assay analysis benefits early drug discovery

Drug Discovery World

DDW Editor Reece Armstrong speaks to Abraham Wang , Head of Marketing at Collaborative Drug Discovery (CDD) about annotated assays and the advantages they bring to research teams. RA: What advantages can better analysis into assays bring to drug developers? AW : Better analysis into assays offers a multitude of advantages, including an enhanced understanding of compound activity and early identification of promising candidates.

Drugs 147
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Interstellar signal linked to aliens was actually just a truck

Science Daily: Pharmacology News

Sound waves thought to be from a 2014 meteor fireball north of Papua New Guinea were almost certainly vibrations from a truck rumbling along a nearby road, new research shows. The findings raise doubts that materials pulled last year from the ocean are alien materials from that meteor, as was widely reported.

Research 118
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Wegovy, Ozempic Use Could Complicate Your Surgery

Drugs.com

WEDNESDAY, March 6, 2024 -- Weight-loss drugs like Wegovy and Ozempic can increase a person’s risk of throwing up during surgery while under anesthesia, a new study reports. People are typically asked to fast prior to surgery because general.

Drugs 116
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Bayer pays $310M to buy into BridgeBio heart drug

BioPharma Drive: Drug Pricing

The deal gives the German pharma partial rights to a closely watched medicine for transthyretin amyloidosis cardiomyopathy that analysts expect to become a multibillion-dollar product.

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FDA advisory committee meeting delays approval of donanemab

Drug Discovery World

The US Food and Drug Administration (FDA) has revealed plans to convene a meeting of the Peripheral and Central Nervous System Drugs Advisory Committee (PCNS) to discuss the Phase III TRAILBLAZER-ALZ 2 trial. The trial evaluated the efficacy and safety of Eli Lilly’s donanemab in early symptomatic Alzheimer’s disease. The FDA has said it hopes to further understand topics related to evaluating the safety and efficacy of donanemab, including the safety results in donanemab-treated patients

FDA 130
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Children surpass a year of HIV remission after treatment pause

Science Daily: Pharmacology News

Four children have remained free of detectable HIV for more than one year after their antiretroviral therapy (ART) was paused to see if they could achieve HIV remission, according to new research. The children, who acquired HIV before birth, were enrolled in a clinical trial in which an ART regimen was started within 48 hours of birth and then closely monitored for drug safety and HIV viral suppression.

Treatment 118
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It’s Time To Update Your Data Lake Ingestion Strategy

Perficient: Drug Development

If you built your data lake in the last 5-7 years, you probably are ingesting data into the data lake using many batch jobs that ingest and update data in the data lake. There is nothing wrong with what you did, but data technology has continued to move forward and in my opinion, the time has come to change your data lake ingestion strategy to reduce the number of high-latency batch jobs and move toward primarily using real-time change data capture (CDC).

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A close research partnership with African scientists helps solve the mystery of malaria-like illnesses

Broad Institute

A close research partnership with African scientists helps solve the mystery of malaria-like illnesses By Claire Hendershot March 8, 2024 Breadcrumb Home A close research partnership with African scientists helps solve the mystery of malaria-like illnesses Two scientists discuss how they used genetic sequencing to identify causes of malaria-mimicking infections in Senegal.

Research 111
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This week in drug discovery (4-8 March) 

Drug Discovery World

News round-up for 4-8 March by DDW Digital Content Editor Diana Spencer. It was antibodies hitting the headlines this week, with the discovery of antibodies with potential against a new influenza target, the launch of a Phase I trial to investigate a novel type of bispecific antibody, and the announcement that the FDA will delay approval of donanemab to hold a meeting of the Peripheral and Central Nervous System Drugs Advisory Committee.

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Fossils of giant sea lizard with dagger-like teeth show how our oceans have fundamentally changed since the dinosaur era

Science Daily: Pharmacology News

Fossils of a strange new species of marine lizard with dagger-like teeth that lived 66 million years ago, show a dramatically more biodiverse ocean ecosystem to what we see today.

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U.S. School Shootings Have Risen 12-fold Since 1970

Drugs.com

FRIDAY, March 8, 2024 -- During the past half-century, the United States’ annual number of school shootings has increased more than twelvefold, a new study finds.What’s more, children are now four times more likely to be a school shooting.

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LACTOSE-Free Medicines: Which Drugs Contain LACTOSE?

Drug Patent Watch

LACTOSE-Free Medicines, 2024 is part of DrugPatentWatch’s deep library of business intelligence on biopharmaceutical drugs. Buy Lactose-Free Medicines from Amazon This guide is designed to provide information for healthcare providers to… The post LACTOSE-Free Medicines: Which Drugs Contain LACTOSE? appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 111
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Humanised bispecific antibody for asthma enters Phase I trial

Drug Discovery World

Biopharmaceutical company Innovent Biologics has launched the first-in-human (FIH) Phase I clinical trial of IBI3002, a novel bispecific antibody targeting Interleukin 4 receptor α (IL-4Rα) and thymic stromal lymphopoietin (TSLP). The study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of IBI3002 in healthy participants and participants with mild to moderate asthma.

Trials 130
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Astronomers spot oldest 'dead' galaxy yet observed

Science Daily: Pharmacology News

A galaxy that suddenly stopped forming new stars more than 13 billion years ago has been observed by astronomers. Using the James Webb Space Telescope, astronomers have spotted a 'dead' galaxy when the universe was just 700 million years old, the oldest such galaxy ever observed.

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How to Use the Personalization Connector for Salesforce Sales and Service Clouds

Perficient: Drug Development

Have you ever wondered what happens if you connected Personalization with Sales and Service Clouds? The Personalization connector for Sales and Service Clouds exposes user data and server-side campaigns in Salesforce CRM for your contacts and leads. The Key for Success To use Personalization for Sales and Service Clouds, you’ll need to have: User identity systems fully working.

Packaging 110