Broad Institute

JUNE 28, 2023

They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells. The new study demonstrates that RNA-guided DNA-cutting mechanisms are present across all kingdoms of life. said Zhang.

RNA 139

RNA DNA Research Engineering 139

Broad Institute

MAY 14, 2025

Cas9 ancestor engineered into a compact genome editing tool By Tom Ulrich May 14, 2025 Breadcrumb Home Cas9 ancestor engineered into a compact genome editing tool Researchers adapt a compact RNA-guided enzyme from bacteria for a variety of DNA editing tasks in human cells.

Engineering 52

Engineering DNA RNA Therapies 52

addgene Blog

JUNE 4, 2024

Have you ever designed a CRISPR guide RNA and wondered why it is limited to only 20 bases, or why it’s so important to choose a target sequence with a nearby protospacer-adjacent motif (PAM) ?

RNA 105

RNA Engineering 105

Drug Target Review

JUNE 6, 2023

At Alkermes , our interdisciplinary team of protein engineers, immunologists, pharmacologists, and analytical scientists is investigating the biology of several immunomodulatory cytokines including IL-12 and IL-18 to develop novel versions of these molecules with the goal of harnessing their therapeutic potential.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

Drug Target Review

JANUARY 2, 2024

Forging the toolkit for subcellular omics Cellular components known as organelles, consisting of RNA and protein, exert vital influences on human wellbeing and ailments by sustaining equilibrium, managing growth and ageing, and producing energy.

RNA 128

RNA Immune Response Therapies Disease 128

Broad Institute

AUGUST 31, 2023

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

DNA 145

DNA RNA Engineering Laboratories 145

Broad Institute

NOVEMBER 23, 2023

The scientists found a surprising number and diversity of CRISPR systems, including ones that could make edits to DNA in human cells, others that can target RNA, and many with a variety of other functions. The new systems could potentially be harnessed to edit mammalian cells with fewer off-target effects than current Cas9 systems.

RNA 135

RNA DNA Engineering Science 135

Fierce BioTech

JULY 1, 2024

Streamlining the Path from Discovery to Patient – Simpler RNA Manufacturing with Aldevron’s Codex® HiCap RNA Polymerase swheeler Mon, 07/01/2024 - 17:17 Wed, 08/07/2024 - 10:00 Resource Type Webinar Kyle Studey, M.S. Codex ® is a trademark of Codexis, Inc. Listing Image aldevron 250x190.png

RNA 40

RNA Engineering Research 40

Dark Matter Blog

AUGUST 31, 2020

Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA. Today, we are pleased to announce that our article describing one such platform: “ PEARL-seq, A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions ” was published in ACS Chemical Biology.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Drug Target Review

JULY 5, 2023

At PEGS Europe, Drug Target Review spoke to Victoria Goldenshtein, a PhD candidate in Biomedical Engineering at Duke University, US, who presented an engaging poster on her lab’s novel in vitro library display platform for directed protein evolution termed GRIP Display, which entails Gluing RNA to Its Proteins.

RNA 97

RNA Engineering Disease Drugs 97

Broad Institute

MAY 16, 2024

By Allessandra DiCorato May 16, 2024 Credit: Deverman lab Brain vasculature (in blue) surrounded by RNA (in orange) transcribed from the gene delivered to the brain in humanized mice using an engineered AAV targeting the human transferrin receptor. This engineered capsid opens up a world of possibilities."

Therapies 137

Therapies FDA Approval Engineering Disease 137

The Open Targets Blog

JANUARY 30, 2025

  “Sam has an exceptional talent in software engineering, and his contributions reflect a deep understanding of both the technical and biological aspects required for bioinformatics tool development,” says Laura Luebbert, now a postdoctoral fellow in the Sabeti lab at the Broad Institute of MIT and Harvard and Harvard University.

Bioinformatics 76

Bioinformatics Immune Response RNA Packaging 76

The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

Senior Director, R&D Strategy, will be delivering a presentation highlighting how Strateos' smart lab platform accelerated riboswitch engineering to develop novel biosensors. Owing to their modular organization, riboswitches are ideal for engineering de novo sensing elements for use in synthetic biology.

Engineering 52

Engineering Protein Expression Research Laboratories RNA 52

Drug Target Review

JULY 7, 2023

This level of control is not achievable with gene editing and is a severe limitation in applications such as T-cell engineering, where precise epigenetic remodelling during differentiation 3 fundamentally shapes the phenotype and function of the cell. RNA-guided transcriptional silencing in vivo with S. Molecular Therapy.

DNA 105

DNA Engineering Therapies Regulations 105

Broad Institute

FEBRUARY 24, 2025

Although this ancestral replicase appears to have been lost, key aspects of RNA-catalyzed RNA replication can be studied by proxy with the use of modern RNA enzymes (ribozymes) generated by in vitro evolution. However, none of these RPRs was capable of self-replication.

RNA 52

RNA Molecular Biology Laboratories Engineering 52

Drug Target Review

JULY 5, 2023

iPSC-derived lymphocytes, eg, T cells and natural killer (NK) cells, engineered to express targeting molecules such as chimeric antigen receptors (CARs) have shown clinical promise to treat haematological malignancies. We believe this lays the groundwork for engineering these kinds of myeloid cells to potentially target any cancer antigen.

Therapies 103

Therapies DNA Engineering Virus 103

Molecule Blog

MARCH 17, 2023

In this regard, BioDAOs can be viewed as collaborative research translation engines and a novel form of biotech organization that develops IP through an online-native approach. By fostering a community of stakeholders with aligned incentives and diverse backgrounds, BioDAOs facilitate the translation of technologies.

Engineering 52

Engineering Research Clinical Trials Government 52

Broad Institute

DECEMBER 13, 2023

The other study was led by senior authors Xiao Wang , a Broad core institute member, a Merkin Institute Fellow, and an assistant professor of chemistry at MIT, and Jia Liu, an assistant professor of engineering at Harvard University. Related news Researchers map brain cell changes in Alzheimer’s disease Courtesy of the Chen and Macosko labs.

DNA 140

DNA Virus Research Engineering 140

Dark Matter Blog

JUNE 21, 2023

On the other hand, if you have a platform designed to be an engine for a standalone enterprise, capable of generating dozens of future drugs, then you might plot a course that brings you into the close orbit of multiple complementary partners. We all share a common understanding of the benefits and challenges of small molecule therapeutics.

Small Molecule 52

Small Molecule RNA Pharma Companies Science 52

The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen. ABOUT SPECTRUM SOLUTIONS AND SPECTRUM DNA.

RNA 52

RNA DNA Engineering Virus 52

The Pharma Data

JANUARY 19, 2021

In the paper, researchers from Johns Hopkins University and elsewhere found a natural long-form transactivating CRISPR RNA (tracr-L) in Streptococcus pyogenes that functions to downregulate its endogenous CRISPR-Cas9 system. But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts.

Research 52

Research RNA Molecular Biology Small Molecule 52

Codon

JUNE 11, 2024

Their solution was to fuse hairpins, little loops made from RNA or DNA, at various positions along the DNA strand that was being sequenced. 3 Nanopore engineers decided to cleverly exploit the natural speed limit of DNA polymerase to slow down DNA translocation through the pores. 3 This speed varies depending on the organism.

DNA 99

DNA Engineering RNA Small Molecule 99

Drug Target Review

FEBRUARY 7, 2024

For example, innate immune peptides being imitated by SARS-CoV-2 fragments have a special ability to organise double stranded RNA into structures that strongly amplify activation of the human innate immune system in autoimmune diseases. He currently serves on the Editorial Board of Physical Review E.

RNA 69

RNA Virus Immune Response Engineering 69

Drug Target Review

JULY 23, 2024

This laid the groundwork for my career in drug discovery using novel modalities like small molecule inhibitors, antibodies, RNA interference (RNAi) and, currently, small molecule protein degraders – which are opportunities to change how we think about medicines.

Small Molecule 116

Small Molecule Targeted Protein Degradation Science Disease 116

The Pharma Data

DECEMBER 8, 2020

The company’s product candidates consist of novel human cells engineered to produce the crucial proteins, enzymes or factors needed by patients living with chronic diseases such as hemophilia, diabetes and lysosomal storage disorders. Laying down a new track for RNA processing, Remix launched with $81 million in financing.

RNA 52

RNA Therapies Disease Protein Expression 52

Broad Institute

JULY 26, 2022

Learn more COVID-19 portals and datasets Broad data scientists and software engineers have developed several portals and datasets to support COVID-19-related research. Learn more Genome Analysis Toolkit (GATK) Industry standard for identifying SNPs and indels in germline DNA- and RNA-seq data.

Compound Screening 52

Compound Screening FDA Approval Engineering RNA 52

Broad Institute

JULY 11, 2024

"These findings reveal a completely unexpected and fascinating mechanism that explains the efficacy of the drug," Manguso, who is a principal investigator at MGH, a co-director of the Tumor Immunology Discovery Engine (TIDE) group, and a Cancer Program associate member at Broad, said.

Treatment 72

Treatment Immune Response Drugs Virus 72

Vial

DECEMBER 5, 2023

Transforming Genomics Research Next-generation sequencing (NGS) enables comprehensive genome sequencing and has transformed genomics research, offering vastly improved capabilities for analyzing DNA and RNA in a high-throughput and cost-effective manner. We have built a global, full-service CRO powered by intuitive end-to-end technology.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

The Open Targets Blog

AUGUST 15, 2023

These results were corroborated by an RNA sequencing analysis we carried out in parallel, which revealed that depending on the temperature, RBM3 had different isoforms created by differential self-splicing. RBM3 is an RNA-binding protein, and we needed an RNA biologist, which is when Deepak joined the project.

RNA 52

RNA Treatment Regulations DNA 52

Drug Target Review

JUNE 11, 2024

My interest in STEM came from a natural curiosity into how things work, as well as from my parents and grandfather who did STEM studies (physics, biology, engineering). However, there’s still a notable underrepresentation in fields like computer and engineering occupations.

Engineering 64

Engineering Science Molecular Biology Doctors 64

The Pharma Data

AUGUST 16, 2021

The CureVac-GSK COVID-19 collaboration announced in February 2021 extends the existing strategic mRNA technology partnership both companies started in July 2020, which focuses on the development of new products based on CureVac’s second-generation RNA-technology for different targets in the field of infectious diseases.

Immune Response 52

Immune Response Vaccine Virus RNA 52

Drug Target Review

SEPTEMBER 28, 2023

Because I was put into the highest tier, I was automatically mapped to the engineering track. Researchers were able to use our synthetic RNA controls as a reference to verify and validate assays. I was very good at math, which at the time in France directed me towards STEM studies.

DNA 116

DNA Organic Chemistry Science Virus 116

The Pharma Data

OCTOBER 19, 2020

The company’s suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions.

Clinical Trials 52

Clinical Trials RNA DNA Science 52

Drug Target Review

AUGUST 10, 2023

In the top row, human lung cancer cells were engineered to over-express GRP78 in the nucleus. Researchers from the Keck School of Medicine of USC used imaging techniques to study how the protein GRP78 controls cancer cell behavior. In the bottom row, cells lacked GRP78 in the nucleus.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

The Pharma Data

SEPTEMBER 30, 2021

Anderson Professor of Chemical and Biomolecular Engineering, and his colleagues, are reporting in iScience the event of an intranasal subunit vaccine that gives durable local immunity against inhaled pathogens. But now, we’re one step closer. Navin Varadarajan, University of Houston M.D.

Vaccine 52

Vaccine Disease Immune Response Virus 52

The Pharma Data

JANUARY 22, 2021

As research developments into RNA vaccines help scientists accelerate drug candidates to arm the immune system against coronavirus, Pharma IQ ’s Keeping tabs on Covid-19 update returns with news from some of the biotechnology innovators leading the fight against the global pandemic.

Vaccine 52

Vaccine Immune Response Government RNA 52

The Pharma Data

DECEMBER 2, 2020

She is currently the CEO of Twentyeight-Seven, a biotech company focused on novel RNA biology that she co-founded alongside prominent Harvard investigators. Enthera’s discovery engine and assets are protected by a broad portfolio of patents. The Company is backed by Sofinnova Partners and JDRF T1D fund. Connect with us on LinkedIn.

Pharmaceuticals 52

Pharmaceuticals Synthetic Chemistry RNA Disease 52