Research - Drug Discovery Digest

Researchers make breakthrough in bioprinting functional human heart tissue

Science Daily: Pharmacology News

JANUARY 22, 2025

Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development.

Research

Research Science Disease Drugs

Researchers use machine learning to engineer 'bespoke enzymes' for gene editing

Science Daily: Pharmacology News

APRIL 22, 2025

The work could help reduce off-target effects and improve editing safety, enhance editing efficiency, and enable researchers to predict customized enzymes for new therapeutic targets. In their study, authors developed a machine learning algorithm -- known as PAMmla -- that can predict the properties of about 64 million genome editing enzymes.

Engineering

Engineering Research Therapies

Researchers devise new way to target and correct disease-related proteins

Broad Institute

JANUARY 6, 2025

Researchers at the Broad Institute of MIT and Harvard, Massachusetts General Hospital, and Harvard University took a fresh approach by building a remarkably diverse collection of molecular compounds that can be mined for those that target disease-related genetic variants in new ways.

Disease

Disease Research DNA Small Molecule

Researchers flip genes on and off with AI-designed DNA switches

Science Daily: Pharmacology News

OCTOBER 23, 2024

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.

DNA

DNA Research

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

But its impact goes far beyond research. From Research to Real-World Care 🌎 Understand how AI-driven advancements are shaping personalized treatments and patient outcomes. AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis.

Clinical Trials

Researchers create gel that can self-heal like human skin

Science Daily: Pharmacology News

MARCH 7, 2025

Now, a team of researchers has developed a hydrogel with a unique structure that overcomes earlier limitations, opening the door to applications such as drug delivery, wound healing, soft robotics sensors and artificial skin.

Research

Research Drugs

Researchers make comfortable materials that generate power when worn

Science Daily: Pharmacology News

JANUARY 15, 2025

Researchers have demonstrated new wearable technologies that both generate electricity from human movement and improve the comfort of the technology for the people wearing them. The work stems from an advanced understanding of materials that increase comfort in textiles and produce electricity when they rub against another surface.

Research

Researchers discover simple solution to break down forever chemicals

Science Daily: Pharmacology News

FEBRUARY 5, 2025

A researcher has discovered a new method to remove so-called 'forever chemicals' from our drinking water by heating the PFAS with granular activated carbon. The discovery represents a significant breakthrough in managing PFAS-containing solid wastes, biosolids and spent adsorbent media that are major concerns to farmers and communities.

Research

Monkeys are world's best yodellers -- new research

Science Daily: Pharmacology News

APRIL 2, 2025

The research provides significant new insights into the diverse vocal sounds of non-human primates, and reveals for the first time how certain calls are produced. The researchers have discovered that special anatomical structures called vocal membranes allow monkeys to introduce 'voice breaks' to their calls.

Research

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management.

Clinical Trials

Researchers combine holograms and AI to create uncrackable optical encryption system

Science Daily: Pharmacology News

JANUARY 30, 2025

Researchers developed a new optical system that uses holograms to encode information, creating a level of encryption that traditional methods cannot penetrate.

Research

New research shatters long-held beliefs about asteroid Vesta

Science Daily: Pharmacology News

APRIL 28, 2025

Now, new research flips this notion on its head. These findings startled researchers who, until that point, assumed Vesta was a protoplanet that never grew to a full planet. Astronomers reveals Vesta doesn't have a core.

Research

Research shows how hormone can reverse fatty liver disease in mice

Science Daily: Pharmacology News

MAY 14, 2025

A pioneering research study details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. The hormone works primarily by signaling the brain to improve liver function.

Disease

Disease Research

Black holes: not endings, but beginnings? New research could revolutionize our understanding of the universe

Science Daily: Pharmacology News

MARCH 12, 2025

New research suggests black holes may transition into 'white holes', ejecting matter and potentially even time back into the universe, defying our current understanding of these cosmic giants.

Research

Researchers demonstrate the UK's first long-distance ultra-secure communication over a quantum network

Science Daily: Pharmacology News

APRIL 7, 2025

Researchers have successfully demonstrated the UK's first long-distance ultra-secure transfer of data over a quantum communications network, including the UK's first long-distance quantum-secured video call.

Research

What's the best way to organize people to generate ideas? New research offers insight

Science Daily: Pharmacology News

FEBRUARY 4, 2025

New research offers insight into these questions -- and some of the results are not what you'd expect. Is it better to work in large groups? Smaller ones? With other people who are similar or different?

Research

Count Me In launches new patient-partnered research project for translocation renal cell carcinoma

Broad Institute

MARCH 11, 2025

By Count Me In Communications March 11, 2025 Count Me In , a patient-partnered research initiative led by the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute, is launching a new project focused on translocation renal cell carcinoma (tRCC), a rare and aggressive form of kidney cancer.

Research

Research Medical Schools Treatment Disease

Memories are not only in the brain, new research finds

Science Daily: Pharmacology News

NOVEMBER 7, 2024

It's common knowledge that our brains -- and, specifically, our brain cells -- store memories.

Research

Invisible currents at the edge: Research team shows how magnetic particles reveal a hidden rule of nature

Science Daily: Pharmacology News

MAY 19, 2025

If you've ever watched a flock of birds move in perfect unison or seen ripples travel across a pond, you've witnessed nature's remarkable ability to coordinate motion.

Engineering

Engineering Research

World's largest bat organoid platform paves the way for pandemic preparedness

Science Daily: Pharmacology News

MAY 15, 2025

Until now, most research has used either generalized cell samples or organoids made from just one type of tropical fruit bat, and only from a single organ. But a breakthrough has arrived: a research team has now created the world's most comprehensive bat organoid platform.

Research

New research kindles excitement around stem cell therapies for Parkinson’s

BioPharma Drive: Drug Pricing

APRIL 16, 2025

Two studies published in Nature found stem cell-derived products can not only be safely transplanted into the brain, but also show promising — albeit unproven — signs of efficacy.

Therapies

Therapies Research Production

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

BioPharma Drive: Drug Pricing

JANUARY 30, 2025

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

FDA Approval

FDA Approval Doctors Research FDA

Predator robots help researchers uncover how larval zebrafish rapidly learn

Science Daily: Pharmacology News

FEBRUARY 20, 2025

A novel system that chases larval zebrafish around an arena with predator robots is enabling scientists to understand how these days-old fish quickly learn in the real world.

Research

Are you curious? It might help you stay sharp as you age

Science Daily: Pharmacology News

MAY 7, 2025

Psychologists shows one type of curiosity can increase well into old age, contradicting prior research. Psychology literature has shown that curiosity tends to decline with age. Older adults who maintain curiosity and want to learn new things relevant to their interests may be able to offset or even prevent Alzheimer's disease.

Disease

Disease Research

Black tea and berries could contribute to healthier aging

Science Daily: Pharmacology News

MAY 5, 2025

Higher intakes of black tea, berries, citrus fruits and apples could help to promote healthy aging, new research has found.

Research

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment

Science Daily: Pharmacology News

MAY 15, 2025

A research team has developed and safely delivered a personalized gene editing therapy to treat an infant with a life-threatening, incurable genetic disease. The infant, who was diagnosed with the rare condition carbamoyl phosphate synthetase 1 (CPS1) deficiency shortly after birth, has responded positively to the treatment.

Treatment

Treatment Therapies Disease Research

Zebrafish protein unlocks dormant genes for heart repair

Science Daily: Pharmacology News

JANUARY 2, 2025

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

Therapies

Therapies Research

Do parents really have a favorite child? Here's what new research says

Science Daily: Pharmacology News

JANUARY 16, 2025

A new study found that younger siblings generally receive more favorable treatment from parents. Meanwhile, older siblings are often granted more autonomy, and parents are less controlling towards them as they grow up.

Research

Research Treatment

Boosting evolution: How humans unintentionally altered the skulls of pigs

Science Daily: Pharmacology News

FEBRUARY 10, 2025

The researchers analyzed 3D scans of 135 skulls of wild boars and domestic pigs from the early 20th and 21st centuries. Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs.

Research

New theory of gravity brings long-sought Theory of Everything a crucial step closer

Science Daily: Pharmacology News

MAY 5, 2025

Researchers have developed a new quantum theory of gravity which describes gravity in a way that's compatible with the Standard Model of particle physics, opening the door to an improved understanding of how the universe began.

Research

Too Much Cinnamon May Interfere With Some Medications, Study Shows

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 Consuming too much cinnamon might affect how your body absorbs some medications, new research shows.The study published in the June issue of the journal Food Chemistry: Molecular Sciences looked at how cinnamon and its key.

Science

Science Research

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

NOVEMBER 27, 2024

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.

DNA

DNA Virus Treatment Research

Key players in brain aging: New research identifies age-related damage on a cellular level

Science Daily: Pharmacology News

JANUARY 1, 2025

Scientists have identified the molecular changes that occur in the brains of aging mice and located a hot spot where much of that damage is centralized. The cells in the area are also connected with metabolism, suggesting a connection between diet and brain health.

Research

Cyberbullying in any form can be traumatizing for kids

Science Daily: Pharmacology News

MAY 15, 2025

New research shows that cyberbullying should be classified as an adverse childhood experience due to its strong link to trauma. Even subtle forms -- like exclusion from group chats -- can trigger PTSD-level distress. Nearly 90% of teens experienced some form of cyberbullying, accounting for 32% of the variation in trauma symptoms.

Research

New research lays groundwork for early detection of Alzheimer's disease

Science Daily: Pharmacology News

APRIL 21, 2025

A new study suggests that risk factors and biomarkers related to Alzheimer's disease are associated with cognition much earlier in life than previously recognized. The study highlights significant associations between cognition and Alzheimer's disease risk factors as young as ages 24 to 44 and underscores the importance of early prevention.

Disease

Disease Research

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

Science Daily: Pharmacology News

OCTOBER 28, 2024

By tweaking a few very specific genes in the neurons of aging fruit flies, the researchers prevented F-actin buildup, maintained cellular recycling and extended the healthy lifespan of fruit flies by approximately 30%. The resulting accumulation of waste diminishes neuronal functions and contributes to cognitive decline.

DNA

DNA Research

A long and ongoing look at the secrets of human longevity and healthy aging

Science Daily: Pharmacology News

MAY 5, 2025

Researchers participating in the Cilento Initiative on Aging Outcomes or CIAO study will gather in Acciaroli (Pollica-Cilento) Salerno, Italy to review a decade of work and plan their next steps.

Research

Brain-wide activity change visualized as geometric patterns

Science Daily: Pharmacology News

FEBRUARY 21, 2025

Researchers have applied a visualization technique to depict the brain's activity related to visual perception as geometric patterns. They visualized different shapes as the ever-changing neuronal activity in the temporal and frontal lobes of the brain during object recognition and recalling memories.

Research

Heat from the sun affects seismic activity on Earth

Science Daily: Pharmacology News

MARCH 4, 2025

Researchers explore the likelihood that Earth's climate, as affected by solar heat, plays a role in seismic activity.

Research

Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

Science Daily: Pharmacology News

MARCH 4, 2025

The groundbreaking procedure was developed to help people with injuries like chemical burns that lead to irreversible limbal stem cell deficiency, and the researchers hope the new findings warrant additional trials.

Clinical Trials

Clinical Trials Trials Therapies Treatment

Scientists track down mutation that makes orange cats orange

Science Daily: Pharmacology News

MAY 15, 2025

In a new study, researchers have discovered the long-posited but elusive genetic mutation that makes orange cats orange -- and it appears to occur in no other mammal. Many an orange cat-affiliated human will vouch for their cat's, let's say, specialness.

Research

Pioneering research exposes huge loss of glaciers in one of the fastest-warming places on Earth

Science Daily: Pharmacology News

JANUARY 16, 2025

A new study has revealed the alarming extent glaciers have shrunk over the past 40 years in a global warming hotspot -- and the biggest retreat has occurred in recent years.

Research

Researchers develop new metallic materials using data-driven frameworks and explainable AI

Science Daily: Pharmacology News

MAY 15, 2025

Found in knee replacements and bone plates, aircraft components, and catalytic converters, the exceptionally strong metals known as multiple principal element alloys (MPEA) are about to get even stronger through to artificial intelligence.

Research

Breakthrough in clean energy: Palladium nanosheets pave way for affordable hydrogen

Science Daily: Pharmacology News

MARCH 4, 2025

In order to address this challenge, researchers have developed Bis(diimino)palladium coordination nanosheets (PdDI), a novel two-dimensional electrocatalyst that effectively facilitates the hydrogen evolution reactions while minimizing the use of precious metals like platinum, paving the way for affordable hydrogen production.

Production

Production Research

Researchers make breakthrough in bioprinting functional human heart tissue

Researchers use machine learning to engineer 'bespoke enzymes' for gene editing

Trending Sources

Researchers devise new way to target and correct disease-related proteins

Researchers flip genes on and off with AI-designed DNA switches

Bridging Innovation & Patient Care: The Growing Role of AI

Researchers create gel that can self-heal like human skin

Researchers make comfortable materials that generate power when worn

Researchers discover simple solution to break down forever chemicals

Monkeys are world's best yodellers -- new research

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Researchers combine holograms and AI to create uncrackable optical encryption system

New research shatters long-held beliefs about asteroid Vesta

Research shows how hormone can reverse fatty liver disease in mice

Black holes: not endings, but beginnings? New research could revolutionize our understanding of the universe

Researchers demonstrate the UK's first long-distance ultra-secure communication over a quantum network

What's the best way to organize people to generate ideas? New research offers insight

Count Me In launches new patient-partnered research project for translocation renal cell carcinoma

Memories are not only in the brain, new research finds

Invisible currents at the edge: Research team shows how magnetic particles reveal a hidden rule of nature

World's largest bat organoid platform paves the way for pandemic preparedness

New research kindles excitement around stem cell therapies for Parkinson’s

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

Predator robots help researchers uncover how larval zebrafish rapidly learn

Are you curious? It might help you stay sharp as you age

Black tea and berries could contribute to healthier aging

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment

Zebrafish protein unlocks dormant genes for heart repair

Do parents really have a favorite child? Here's what new research says

Boosting evolution: How humans unintentionally altered the skulls of pigs

New theory of gravity brings long-sought Theory of Everything a crucial step closer

Too Much Cinnamon May Interfere With Some Medications, Study Shows

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Key players in brain aging: New research identifies age-related damage on a cellular level

Cyberbullying in any form can be traumatizing for kids

New research lays groundwork for early detection of Alzheimer's disease

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

A long and ongoing look at the secrets of human longevity and healthy aging

Brain-wide activity change visualized as geometric patterns

Heat from the sun affects seismic activity on Earth

Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

Scientists track down mutation that makes orange cats orange

Pioneering research exposes huge loss of glaciers in one of the fastest-warming places on Earth

Researchers develop new metallic materials using data-driven frameworks and explainable AI

Breakthrough in clean energy: Palladium nanosheets pave way for affordable hydrogen

Stay Connected