Research - Drug Discovery Digest

Researchers make breakthrough in bioprinting functional human heart tissue

Science Daily: Pharmacology News

JANUARY 22, 2025

Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development.

Research

Research Science Disease Drugs

Research shows how solar arrays can aid grasslands during drought

Science Daily: Pharmacology News

JUNE 2, 2025

New research shows that the presence of solar panels in Colorado's grasslands may reduce water stress, improve soil moisture levels and -- particularly during dry years -- increase plant growth by about 20% or more compared to open fields.

Research

Researchers use machine learning to engineer 'bespoke enzymes' for gene editing

Science Daily: Pharmacology News

APRIL 22, 2025

The work could help reduce off-target effects and improve editing safety, enhance editing efficiency, and enable researchers to predict customized enzymes for new therapeutic targets. In their study, authors developed a machine learning algorithm -- known as PAMmla -- that can predict the properties of about 64 million genome editing enzymes.

Engineering

Engineering Research Therapies

Researchers restore antibiotic effect in the event of resistance

Science Daily: Pharmacology News

MAY 7, 2025

Using mouse models, researchers now show that if antibiotics are administered with an enzyme called endolysin, the combined effect protects against infection by resistant bacteria in all bodily organs -- including the brain, which antibiotics alone have difficulty reaching.

Research

Research Treatment

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

But its impact goes far beyond research. From Research to Real-World Care 🌎 Understand how AI-driven advancements are shaping personalized treatments and patient outcomes. AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis.

Clinical Trials

Researchers devise new way to target and correct disease-related proteins

Broad Institute

JANUARY 6, 2025

Researchers at the Broad Institute of MIT and Harvard, Massachusetts General Hospital, and Harvard University took a fresh approach by building a remarkably diverse collection of molecular compounds that can be mined for those that target disease-related genetic variants in new ways.

Disease

Disease Research DNA Small Molecule

Researchers flip genes on and off with AI-designed DNA switches

Science Daily: Pharmacology News

OCTOBER 23, 2024

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.

DNA

DNA Research

Researchers identify previously unknown compound in drinking water

Science Daily: Pharmacology News

NOVEMBER 21, 2024

Researchers have reported the discovery of a previously unknown compound in chloraminated drinking water. Inorganic chloramines are commonly used to disinfect drinking water to safeguard public health from diseases like cholera and typhoid fever.

Research

Research Disease

Researchers create gel that can self-heal like human skin

Science Daily: Pharmacology News

MARCH 7, 2025

Now, a team of researchers has developed a hydrogel with a unique structure that overcomes earlier limitations, opening the door to applications such as drug delivery, wound healing, soft robotics sensors and artificial skin.

Research

Research Drugs

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management.

Clinical Trials

Researchers discover simple solution to break down forever chemicals

Science Daily: Pharmacology News

FEBRUARY 5, 2025

A researcher has discovered a new method to remove so-called 'forever chemicals' from our drinking water by heating the PFAS with granular activated carbon. The discovery represents a significant breakthrough in managing PFAS-containing solid wastes, biosolids and spent adsorbent media that are major concerns to farmers and communities.

Research

With AI, researchers predict the location of virtually any protein within a human cell

Broad Institute

MAY 19, 2025

With AI, researchers predict the location of virtually any protein within a human cell By Corie Lok May 19, 2025 Breadcrumb Home With AI, researchers predict the location of virtually any protein within a human cell Trained with a joint understanding of protein and cell behavior, the model could help with diagnosing disease and developing new drugs.

Research

Research Engineering Science Disease

Broad Institute and Manifold collaborate to build AI-enabled life sciences research platform to accelerate global discoveries

Broad Institute

JANUARY 13, 2025

By TK January 13, 2025 The Broad Institute of MIT and Harvard today announced a strategic collaboration with Manifold , a leader in research infrastructure for biomedical science, to develop a cutting-edge research platform. Founded in 2016, Manifold is an AI-powered platform accelerating biomedical research.

Science

Science Research Engineering Government

Black holes: not endings, but beginnings? New research could revolutionize our understanding of the universe

Science Daily: Pharmacology News

MARCH 12, 2025

New research suggests black holes may transition into 'white holes', ejecting matter and potentially even time back into the universe, defying our current understanding of these cosmic giants.

Research

Researchers demonstrate the UK's first long-distance ultra-secure communication over a quantum network

Science Daily: Pharmacology News

APRIL 7, 2025

Researchers have successfully demonstrated the UK's first long-distance ultra-secure transfer of data over a quantum communications network, including the UK's first long-distance quantum-secured video call.

Research

Researchers demonstrate 3-D printing technology to improve comfort, durability of 'smart wearables'

Science Daily: Pharmacology News

MAY 13, 2025

It may be closer than you think, with new research demonstrating a particular 3-D ink printing method for so-called smart fabrics that continue to perform well after repeated washings and abrasion tests. Imagine a T-shirt that could monitor your heart rate or blood pressure.

Research

Count Me In launches new patient-partnered research project for translocation renal cell carcinoma

Broad Institute

MARCH 11, 2025

By Count Me In Communications March 11, 2025 Count Me In , a patient-partnered research initiative led by the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute, is launching a new project focused on translocation renal cell carcinoma (tRCC), a rare and aggressive form of kidney cancer.

Research

Research Medical Schools Treatment Disease

There's A Better Clot-Preventing Option Than Aspirin, Researchers Say

Drugs.com

JUNE 6, 2025

FRIDAY, June 6, 2025 — There’s a better option than daily aspirin to protect heart patients with a stent against dangerous blood clots, a new study found.A class of drugs called P2Y12 inhibitors that includes ticagrelor and clopidogrel could be mor.

Research

Research Drugs

Invisible currents at the edge: Research team shows how magnetic particles reveal a hidden rule of nature

Science Daily: Pharmacology News

MAY 19, 2025

If you've ever watched a flock of birds move in perfect unison or seen ripples travel across a pond, you've witnessed nature's remarkable ability to coordinate motion.

Engineering

Engineering Research

Memories are not only in the brain, new research finds

Science Daily: Pharmacology News

NOVEMBER 7, 2024

It's common knowledge that our brains -- and, specifically, our brain cells -- store memories.

Research

Research advances on 'displacing' antibiotic resistance gene from bacteria

Science Daily: Pharmacology News

MAY 6, 2025

Scientists have identified essential genetic code for a method called plasmid curing, which aims to 'displace' antibiotic resistance genes from bacteria.

Research

Vertex, startup Orna to partner on gene editing research

BioPharma Drive: Drug Pricing

JANUARY 7, 2025

The three-year partnership is another example of Vertex’s interest in improving on Casgevy, its CRISPR medicine for sickle cell and beta thalassemia.

Research

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

BioPharma Drive: Drug Pricing

JANUARY 30, 2025

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

FDA Approval

FDA Approval Doctors Research FDA

New research kindles excitement around stem cell therapies for Parkinson’s

BioPharma Drive: Drug Pricing

APRIL 16, 2025

Two studies published in Nature found stem cell-derived products can not only be safely transplanted into the brain, but also show promising — albeit unproven — signs of efficacy.

Therapies

Therapies Research Production

Zebrafish protein unlocks dormant genes for heart repair

Science Daily: Pharmacology News

JANUARY 2, 2025

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

Therapies

Therapies Research

Mind the band gap! -- researchers create new nanoscale forms of elementary semiconductor with tunable electronic properties

Science Daily: Pharmacology News

MAY 21, 2025

Researchers have demonstrated that by using a semiconductor with flexible bonds, the material can be moulded into various structures using nano containers, without altering its composition, the discovery could lead to the design of a variety of customised electronic devices using only a single element.

Research

Boosting evolution: How humans unintentionally altered the skulls of pigs

Science Daily: Pharmacology News

FEBRUARY 10, 2025

The researchers analyzed 3D scans of 135 skulls of wild boars and domestic pigs from the early 20th and 21st centuries. Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs.

Research

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

NOVEMBER 27, 2024

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.

DNA

DNA Virus Treatment Research

Key players in brain aging: New research identifies age-related damage on a cellular level

Science Daily: Pharmacology News

JANUARY 1, 2025

Scientists have identified the molecular changes that occur in the brains of aging mice and located a hot spot where much of that damage is centralized. The cells in the area are also connected with metabolism, suggesting a connection between diet and brain health.

Research

Regeneron wins bid to buy 23andMe out of bankruptcy

BioPharma Drive: Drug Pricing

MAY 19, 2025

The biotech, which has for years invested in genetics research, plans to acquire "substantially all" of testing firm 23andMe's assets for $256 million.

Research

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

Science Daily: Pharmacology News

OCTOBER 28, 2024

By tweaking a few very specific genes in the neurons of aging fruit flies, the researchers prevented F-actin buildup, maintained cellular recycling and extended the healthy lifespan of fruit flies by approximately 30%. The resulting accumulation of waste diminishes neuronal functions and contributes to cognitive decline.

DNA

DNA Research

World's largest bat organoid platform paves the way for pandemic preparedness

Science Daily: Pharmacology News

MAY 15, 2025

Until now, most research has used either generalized cell samples or organoids made from just one type of tropical fruit bat, and only from a single organ. But a breakthrough has arrived: a research team has now created the world's most comprehensive bat organoid platform.

Research

A new technology for extending the shelf life of produce

Science Daily: Pharmacology News

MAY 21, 2025

Researchers developed a way to extend the shelf life of vegetables by injecting them with melatonin using biodegradable microneedles.

Research

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment

Science Daily: Pharmacology News

MAY 15, 2025

A research team has developed and safely delivered a personalized gene editing therapy to treat an infant with a life-threatening, incurable genetic disease. The infant, who was diagnosed with the rare condition carbamoyl phosphate synthetase 1 (CPS1) deficiency shortly after birth, has responded positively to the treatment.

Treatment

Treatment Therapies Disease Research

Brain-wide activity change visualized as geometric patterns

Science Daily: Pharmacology News

FEBRUARY 21, 2025

Researchers have applied a visualization technique to depict the brain's activity related to visual perception as geometric patterns. They visualized different shapes as the ever-changing neuronal activity in the temporal and frontal lobes of the brain during object recognition and recalling memories.

Research

Are you curious? It might help you stay sharp as you age

Science Daily: Pharmacology News

MAY 7, 2025

Psychologists shows one type of curiosity can increase well into old age, contradicting prior research. Psychology literature has shown that curiosity tends to decline with age. Older adults who maintain curiosity and want to learn new things relevant to their interests may be able to offset or even prevent Alzheimer's disease.

Disease

Disease Research

Being in nature can help people with chronic back pain manage their condition

Science Daily: Pharmacology News

JUNE 3, 2025

Researchers asked patients, some of whom had experienced lower back pain for up to 40 years, if being in nature helped them coped better with their lower back pain. They found that people able to spend time in their own gardens saw some health and wellbeing benefits.

Treatment

Treatment Research

Glaciers will take centuries to recover even if global warming is reversed, scientists warn

Science Daily: Pharmacology News

MAY 19, 2025

New research reveals mountain glaciers across the globe will not recover for centuries -- even if human intervention cools the planet back to the 1.5 C limit, having exceeded it.

Research

Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

Science Daily: Pharmacology News

MARCH 4, 2025

The groundbreaking procedure was developed to help people with injuries like chemical burns that lead to irreversible limbal stem cell deficiency, and the researchers hope the new findings warrant additional trials.

Clinical Trials

Clinical Trials Trials Therapies Treatment

Too Much Cinnamon May Interfere With Some Medications, Study Shows

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 Consuming too much cinnamon might affect how your body absorbs some medications, new research shows.The study published in the June issue of the journal Food Chemistry: Molecular Sciences looked at how cinnamon and its key.

Science

Science Research

Cyberbullying in any form can be traumatizing for kids

Science Daily: Pharmacology News

MAY 15, 2025

New research shows that cyberbullying should be classified as an adverse childhood experience due to its strong link to trauma. Even subtle forms -- like exclusion from group chats -- can trigger PTSD-level distress. Nearly 90% of teens experienced some form of cyberbullying, accounting for 32% of the variation in trauma symptoms.

Research

Heat from the sun affects seismic activity on Earth

Science Daily: Pharmacology News

MARCH 4, 2025

Researchers explore the likelihood that Earth's climate, as affected by solar heat, plays a role in seismic activity.

Research

Black tea and berries could contribute to healthier aging

Science Daily: Pharmacology News

MAY 5, 2025

Higher intakes of black tea, berries, citrus fruits and apples could help to promote healthy aging, new research has found.

Research

Scientists discover class of crystals with properties that may prove revolutionary

Science Daily: Pharmacology News

MAY 21, 2025

Researchers have discovered a new class of materials -- called intercrystals -- with unique electronic properties that could power future technologies.

Research

Researchers make breakthrough in bioprinting functional human heart tissue

Research shows how solar arrays can aid grasslands during drought

Trending Sources

Researchers use machine learning to engineer 'bespoke enzymes' for gene editing

Researchers restore antibiotic effect in the event of resistance

Bridging Innovation & Patient Care: The Growing Role of AI

Researchers devise new way to target and correct disease-related proteins

Researchers flip genes on and off with AI-designed DNA switches

Researchers identify previously unknown compound in drinking water

Researchers create gel that can self-heal like human skin

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Researchers discover simple solution to break down forever chemicals

With AI, researchers predict the location of virtually any protein within a human cell

Broad Institute and Manifold collaborate to build AI-enabled life sciences research platform to accelerate global discoveries

Black holes: not endings, but beginnings? New research could revolutionize our understanding of the universe

Researchers demonstrate the UK's first long-distance ultra-secure communication over a quantum network

Researchers demonstrate 3-D printing technology to improve comfort, durability of 'smart wearables'

Count Me In launches new patient-partnered research project for translocation renal cell carcinoma

There's A Better Clot-Preventing Option Than Aspirin, Researchers Say

Invisible currents at the edge: Research team shows how magnetic particles reveal a hidden rule of nature

Memories are not only in the brain, new research finds

Research advances on 'displacing' antibiotic resistance gene from bacteria

Vertex, startup Orna to partner on gene editing research

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

New research kindles excitement around stem cell therapies for Parkinson’s

Zebrafish protein unlocks dormant genes for heart repair

Mind the band gap! -- researchers create new nanoscale forms of elementary semiconductor with tunable electronic properties

Boosting evolution: How humans unintentionally altered the skulls of pigs

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Key players in brain aging: New research identifies age-related damage on a cellular level

Regeneron wins bid to buy 23andMe out of bankruptcy

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

World's largest bat organoid platform paves the way for pandemic preparedness

A new technology for extending the shelf life of produce

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment

Brain-wide activity change visualized as geometric patterns

Are you curious? It might help you stay sharp as you age

Being in nature can help people with chronic back pain manage their condition

Glaciers will take centuries to recover even if global warming is reversed, scientists warn

Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

Too Much Cinnamon May Interfere With Some Medications, Study Shows

Cyberbullying in any form can be traumatizing for kids

Heat from the sun affects seismic activity on Earth

Black tea and berries could contribute to healthier aging

Scientists discover class of crystals with properties that may prove revolutionary

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