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Perfume from Extinct Flowers, Thanks to Ancient DNA and Synthetic Biology

PLOS: DNA Science

“Meet Invisible Woods: a clean, refreshing scent revived from extinct flower DNA ,” beneath an image of “origin flower” Wendlandia angustifolia. ” Definitely Zen retreat, because Wendy meditates. • compare the DNA sequence to similar genes in other species. So I clicked. ” Huh?

DNA 119
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#Unshackled: The evolving definition of asset-centricity

DrugBaron

These come in many flavours: it could be a technology thread (editing DNA, protein degraders or engineered stem cells for example), deep expertise in a particular indication (“we are the leaders in endometriosis”), or focus on a particular biological mechanism (antigen-presenting cells, mitophagy, caspases or a million other possibilities).

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PRITELIVIR MESYLATE

New Drug Approvals

Key Aspects of Pritelivir Mesylate Synthesis: Targeted Mechanism: Pritelivir mesylate inhibits the herpes simplex virus by targeting the viral helicase-primase complex, essential for DNA replication, unlike traditional antivirals that target DNA polymerase. First-line treatment is generally acyclovir or its prodrug valacyclovir.

Virus 57
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The Dawn of Molecular Genetics: A Glimpse of History in a Textbook from 1952

PLOS: DNA Science

Vague Definitions and Examples from Nature All genetics textbooks, including mine, relate the convergence of experimental evidence that led Watson and Crick to deduce DNA’s structure. ” The 1952 textbook explains heredity through trait variations, which have long been observed without knowing the role of DNA.

DNA 105
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How chromosome imbalances can drive cancer

Broad Institute

Such large-scale changes in DNA have been difficult to study. Since the deleted or duplicated DNA regions involved in an aneuploidy can include hundreds or thousands of genes, pinning down any molecular mechanism by which an aneuploidy impacts tumor growth has been difficult.

DNA 122
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To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives

Broad Institute

The DNA change underlying Emma’s disorder is now known, thanks to years of work by an international team of scientists and physicians at the Broad Institute of MIT and Harvard, Northwestern University, University of Nantes, the Weizmann Institute of Science, and the Baylor College of Medicine.

DNA 128
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What Biology Can Learn from Physics

Codon

Predictive Models A “ sequence-to-function ” predictive model – an algorithm that determines a protein’s likely function solely by looking at the DNA sequence encoding it – is the natural successor to AlphaFold2. The biggest challenge will be to acquire DNA that encodes millions of different proteins.