Broad Institute

JANUARY 14, 2025

By Allessandra DiCorato January 14, 2025 Credit: Maria Nemchuk, Broad Communications Eric Minikel and Sonia Vallabh run a lab with a singular focus: preventing and treating prion disease within their lifetime. Its a huge privilege to have the opportunity to point these powerful new tools at our disease.

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The Pharma Data

MARCH 23, 2022

Unfortunately, in a Phase 3 clinical trial, treatment with remdesivir did not make a difference in mortality for Ebola virus disease patients. Without the stop sign, viral transcription no longer follows the correct order, which has a negative impact on viral protein production,” says Fang.

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The Pharma Data

DECEMBER 22, 2020

Ltd.] “EME has developed foundational technology that can create new drugs to deal with unmet medical requirements, including infectious diseases for which there are no effective treatments. Comment from Fumiharu Muroga, Growth Manager at Real Tech Fund] “Proteins are an important structural component of living things.

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Dark Matter Blog

JULY 16, 2021

It also captures what drives me and others like me – the opportunity to create a new class of drugs to address diseases not currently treated effectively, but to do so in a novel way. Synta was focused on small molecule drug discovery and development in oncology and inflammatory diseases.

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Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

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The Pharma Data

DECEMBER 3, 2020

The disease is classified as a developmental and epileptic encephalopathy due to the developmental delays and cognitive impairment associated with the disease. Reducing the Time to Diagnosis and Increasing the Detection of Individuals with SCN1A- related Disease Through a Sponsored Epilepsy Genetic Testing Program.

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Codon

JUNE 9, 2025

Several decades of effort to create “artificial life” in the laboratory have produced biochemical machines and self-sustained protein production systems but, as yet, no organisms capable of cell division or robust metabolism. Biotechnologists know this firsthand.

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Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

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PLOS: DNA Science

JUNE 13, 2024

The most compelling evidence for the origin lies in the RNA genome sequence similarities between RaTG13 and SARS-CoV-2 – specifically, a part that encodes the “furin binding site” of the spike protein with which the virus adheres to host cells. Coincidence? I’ve never thought so.

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Codon

MARCH 20, 2023

Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast. Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production. Genetic association analysis of 77,539 genomes reveals rare disease etiologies. Metabolic Engineering. Wendering P.

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Codon

MARCH 24, 2024

In 2012, an Israeli company called Protalix gained approval for their plant-based enzyme product for Gaucher’s disease. Kanuma, their FDA-approved protein product for rare lysosomal diseases, is “purified from the egg white of transgenic hens.”

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The Pharma Data

JANUARY 24, 2021

A key advantage of Elasmogen’s VNAR platform is the ability to bind to their target at sites that are inaccessible to human antibodies translating, in many cases, to increased potency and specificity against the disease.

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The Pharma Data

JANUARY 13, 2021

Sepofarsen has been granted orphan drug designation in the United States and the European Union and received fast-track designation and rare pediatric disease designation from the FDA as well as access to the PRIME scheme by the EMA.

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Codon

MAY 30, 2023

Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Read Modular metabolic engineering and synthetic coculture strategies for the production of aromatic compounds in yeast. Materials Today Bio. Read Living microecological hydrogels for wound healing.

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Codon

MAY 30, 2023

Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Read Modular metabolic engineering and synthetic coculture strategies for the production of aromatic compounds in yeast. Materials Today Bio. Read Living microecological hydrogels for wound healing.

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DNA RNA Engineering Vaccine 52

BMG Labtech

FEBRUARY 24, 2025

The introduction of a nitro- group into a protein molecule is also implicated in different diseases including cardiovascular disease , lung disease, diabetes, cancer and some neurodegenerative conditions. While protein nitration is linked to disease, in many cases its precise physiological function is often unknown.

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Codon

MAY 29, 2025

Ricin is toxic because it inactivates ribosomes, RNA-protein machines that translate each triplet codon of mRNA into its corresponding amino acid, linking them together to form peptides and proteins. This is the step after the initial transcription of DNA into mRNA by RNA Polymerase II, the protein to which alpha amanitin binds.

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Codon

AUGUST 10, 2023

Drug Discovery Today: Disease Models (2008). Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. Link Artificial Gene Regulatory Networks—A Review , by Cussat-Blanc S.

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Codon

AUGUST 10, 2023

Drug Discovery Today: Disease Models (2008). Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. Link Artificial Gene Regulatory Networks—A Review , by Cussat-Blanc S.

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