SCIENMAG: Medicine & Health

JANUARY 24, 2024

Viral genetic material was integrated into the genome of the first multi-cellular beings and is still in our DNA today. All animals have evolved thanks to the fact that certain viruses infected primitive organisms hundreds of millions of years ago.

Virus 69

Virus DNA Science Research 69

Drug Target Review

JUNE 28, 2023

When faced with a viral threat, bacterial cells developed an immune response by capturing and copying DNA fragments of viruses. This allowed bacteria to recognise subsequent attacks and cleave the viral DNA to stop the viral infection. It was also discovered that the Cas enzyme was responsible for DNA cleavage.

Engineering 98

Engineering DNA Immune Response RNA 98

PLOS: DNA Science

JANUARY 25, 2024

We can learn about life, past and present, anywhere we find DNA and determine its sequence. DNA Science has described intriguing sources of environmental DNA, aka eDNA: DNA in Strange Places: Hippo Poop, Zoo Air, and Cave Dirt and A Glimpse of the Ocean’s Twilight Zone Through Environmental DNA.

Disease 97

Disease DNA Science Virus 97

Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. These are synthetic, not the live virus, so do not pose a risk of infection.

DNA 116

DNA Organic Chemistry Science Virus 116

Broad Institute

JUNE 10, 2024

The new method uses a combination of prime editing, which can directly make a wide range of edits up to about 100 or 200 base pairs, and newly developed recombinase enzymes that efficiently insert large pieces of DNA thousands of base pairs in length at specific sites in the genome.

DNA 144

DNA Engineering Therapies Disease 144

SCIENMAG: Medicine & Health

JUNE 16, 2023

As a part of its life cycle, the human immunodeficiency virus-1 (HIV) inserts a copy of its DNA into human immune cells. Some of these newly infected immune cells can then transition into a dormant, latent state for a long period of time, which is referred to as HIV latency. Credit: UNC Division of Infectious […]

DNA 82

DNA Research Virus 82

NIH Director's Blog: Drug Discovery

MARCH 8, 2016

Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we see on everything from package deliveries to clothing tags, they used short, unique snippets of DNA to label cells. DNA barcoding has already empowered single-cell analysis, including for nerve cells in the brain. PRISM consists of two key components.

DNA 52

DNA Drugs Small Molecule FDA Approval 52

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA 98

DNA Engineering RNA Small Molecule 98

PLOS: DNA Science

FEBRUARY 8, 2024

DNA Science recently covered perfumes resurrected from extinct plants, but using older and less precise recombinant DNA technology. appeared first on DNA Science. But will it, can it, improve upon nature? Several species of australopithecines, for example, lived in Africa 2 to 4 million years ago. CRISPR Hubris?

Immune Response 97

Immune Response DNA Engineering Virus 97

Broad Institute

DECEMBER 13, 2023

They transferred 101 serial sections, spanning the volume of a single mouse brain, onto arrays of beads covered in unique DNA barcodes, which bound to the mRNA transcripts in the brain tissue. In their study, the researchers focused on a variant of an engineered recombinant adeno-associated virus (rAAV) known as PHP.eB.

DNA 140

DNA Virus Research Engineering 140

SCIENMAG: Medicine & Health

JULY 11, 2023

The immune system is one of the most complex parts of our body. It keeps us healthy by getting rid of parasites, viruses or bacteria, and by destroying damaged or cancer cells. One of its most intriguing abilities is its memory: upon first contact with a foreign component (called “antigens” in scientific jargon) our adaptive […]

DNA 60

DNA Virus 60

SCIENMAG: Medicine & Health

AUGUST 7, 2023

Prolonged exposure to UVR is associated with damage to DNA in skin cells, […] Skin, the largest organ of the human body, is home to a vast array of bacteria, fungi, and viruses – microorganisms that compose the skin microbiota.

DNA 75

DNA Virus 75

Drug Target Review

JULY 5, 2023

Here, the specificity of the protein is built into the gene-editing protein itself and, unlike earlier generation gene-editing systems, this system is not designed to create double-strand breaks in genomic DNA, but rather is designed to create nicks or single-strand breaks in genomic DNA.

Therapies 104

Therapies DNA Engineering Virus 104

addgene Blog

MAY 30, 2023

Adeno-associated virus (AAV) is a single stranded, Parvoviridae DNA virus, packaged in a non-enveloped icosahedral capsid, that can be used to express genes of interest in cell and animal models. This post was contributed by guest blogger Didem Goz Ayturk with edits and updates from Addgenies Karen Guerin and Susanna Stroik.

Virus 70

Virus Packaging DNA Laboratories 70

SCIENMAG: Medicine & Health

AUGUST 3, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the […] CAMBRIDGE, MA — A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

Regulations 64

Regulations DNA Virus 64

The Premier Consulting Blog

MARCH 7, 2024

For gene therapy vectors, this testing encompasses production cell lines, master and working cell banks (MCB, WCB), and virus banks. Depending on the gene therapy vector, microbial systems may be employed to produce vector DNA (such as in adeno associated virus (AAV)), in which case there may be bacterial cell banks and plasmid banks.

Production 52

Production Therapies DNA Virus 52

Codon

OCTOBER 13, 2024

The chefs at Farma know that by embracing food technologies such as recombinant DNA, precision fermentation, and cell culture, food can become more nutritious and better for the planet. The Hawaiian islands were beset by ringspot virus by the 1950s and within only 12 years, the amount of land used for papaya production dropped by 94 percent.

Engineering 108

Engineering Virus Production DNA 108

Broad Institute

MAY 14, 2025

Cas9 ancestor engineered into a compact genome editing tool By Tom Ulrich May 14, 2025 Breadcrumb Home Cas9 ancestor engineered into a compact genome editing tool Researchers adapt a compact RNA-guided enzyme from bacteria for a variety of DNA editing tasks in human cells. Like Cas9, IscB enzymes cut DNA at sites specified by an RNA guide.

Engineering 52

Engineering DNA RNA Therapies 52

Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Adeno-associated virus as a delivery vector for gene therapy of human diseases. Labcompare. 2024;9(1):78.

Therapies 52

Therapies Virus DNA Compliance 52

Drug Target Review

DECEMBER 7, 2023

In an infected animal, cGAS senses viral DNA in cytoplasm whilst in an uninfected organism, DNA is confined in the nucleus. Bacteria must take a different approach as they do not have nuclei and if CBASS reacted to the presence of DNA, it would cause autoimmunity or the bacterium to attack itself, Banh said.

RNA 59

RNA Immune Response DNA Molecular Biology 59

Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus.

Treatment 72

Treatment Immune Response Drugs Virus 72

DrugBank

JUNE 13, 2024

This approach targets the fundamental instructions within a cell's DNA, either by correcting faulty genes or introducing entirely new ones to combat disease. These viral vectors act as microscopic shuttles, carrying the therapeutic DNA into the host cell's nucleus, where it can integrate into the genome.

Therapies 98

Therapies Drugs DNA Treatment 98

The Pharma Data

SEPTEMBER 1, 2020

The mass surveillance fears come from activists who believe that the DNA samples from the test will be harvested along with a citizen’s personal data to help China expand their surveillance programme from the mainland to the largely self-governing region. million. .

DNA 52

DNA Virus Government Hospitals 52

Drug Target Review

APRIL 17, 2024

Dr Samstein’s research interests are focused on understanding the interaction between the patient’s immune system and cancer cells in the tumour, elucidating the role of the DNA damage repair and response pathways in altering the tumour’s ability to be recognized and attacked by the immune system.

Immune Response 106

Immune Response Laboratories DNA Virus 106

The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. ABOUT SPECTRUM SOLUTIONS AND SPECTRUM DNA. This press release features multimedia. EUA validated viral inactivation data.

RNA 52

RNA DNA Engineering Virus 52

DrugBank

MARCH 12, 2025

This approach can be personalized for each patient by sequencing the tumor's DNA and RNA to identify unique mutations. Unlike gene-editing techniques such as CRISPR-Cas9, which involve permanent alterations to DNA, mRNA provides a transient yet effective means of addressing genetic deficiencies.

Vaccine 97

Vaccine Treatment Clinical Trials Therapies 97

The Pharma Data

JANUARY 11, 2021

The COVID-19 vaccines work by teaching the immune system to protect against the virus, experts said. Neither of the two vaccines approved in the United States — made by Pfizer-BioNTech and Moderna — contains the live virus. “That means it never converts into DNA,” Dr. M.

Vaccine 52

Vaccine Virus DNA Doctors 52

Drug Target Review

SEPTEMBER 8, 2023

The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell. It didn’t have the tools that are important for nuclear receptors, namely the ability to interact with DNA and the ability to translocate from the cytoplasm to the nucleus,” says Cheroutre.

Regulations 98

Regulations Research DNA Immune Response 98

DrugBank

JANUARY 29, 2025

Gene Therapy Gene therapy operates on the principle of modulating the DNA blueprint of cells to induce a therapeutic response. The AAV genome, comprising single-stranded DNA, can persist in the host cell nucleus as an episome or integrate into the host genome at a specific site on chromosome 19.

Therapies 52

Therapies DNA RNA Disease 52

Creative Biolabs

AUGUST 27, 2023

Human immunodeficiency virus 1 (HIV-1) is a retrovirus, and most HIV-1 infections occur on the mucosal surface of the human reproductive tract. After HIV-1 enters the nucleus of the host cell, it integrates its own nucleic acid sequence into the DNA of the host cell and establishes infection within days to weeks. Santos, M.F.,

Virus 52

Virus Drugs DNA Research 52

PLOS: DNA Science

JUNE 1, 2023

This DNA Science post from 2018 traces the history of the efforts. ” The post Topical Gene Therapy FDA-Approved for Severe Skin Disease, Dystrophic Epidermolysis Bullosa appeared first on DNA Science. A dominant form – DDEB – is less severe, blistering the hands, feet, knees, and elbows.

FDA Approval 52

FDA Approval Therapies FDA Disease 52

New Drug Approvals

SEPTEMBER 6, 2024

TLR7-9 are among the set that are endosomally located and respond to single-stranded RNA (TLR7and TLR8) or unmethylated single-stranded DNA containing cytosine-phosphate-guanine (CpG) motifs (TLR9). Toll/IL-1 receptor family members are important regulators of inflammation and host resistance. Nature Immunol., 11:373-384 (2010)).

RNA 62

RNA Clinical Trials Disease DNA 62

The Pharma Data

NOVEMBER 5, 2020

5 of its ongoing Phase 2 extension study, Study 211, examining vebicorvir (VBR, or ABI-H0731) in patients with hepatitis B virus infection. We maintain this can best be accomplished through a combination of agents with different mechanisms of action that target distinct parts of the virus lifecycle. Assembly Biosciences, Inc.

Virus 40

Virus Clinical Trials Therapies Pharmacokinetics 40

The Pharma Data

JANUARY 13, 2021

.” The Johnson & Johnson vaccine also would be hardier than either of the already approved vaccines because it relies on DNA technology rather than messenger RNA to prompt an immune system response. ” Early results from the phase 3 trials are expected by the end of January, Johnson & Johnson has said.

Vaccine 40

Vaccine Trials Clinical Trials Immune Response 40

The Pharma Data

OCTOBER 19, 2020

The company’s suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions.

Clinical Trials 52

Clinical Trials RNA DNA Science 52

KIF1A

FEBRUARY 4, 2024

In addition to sequencing patients, the researchers looked for antibodies to the HTLV-1 virus in the patients’ spinal fluid. We each have two DNA copies of the KIF1A gene; each copy is called an allele and makes its own RNA, which is then translated into protein.

RNA 52

RNA DNA Disease Trials 52

The Pharma Data

OCTOBER 14, 2020

The research is part of an ongoing collaboration between Columbia University and Tonix that focuses on T cell and antibody responses to SARS-CoV-2 (CoV-2), the virus that causes COVID-19. The research encompasses two projects. The study led by Dr. Ilya Trakht, Ph.D., The study led by Dr. Sergei Rudchenko, Ph.D., About TNX-1800.

Vaccine 40

Vaccine Pharmaceuticals Small Molecule Virus 40