Wed.Apr 10, 2024

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Institut Pasteur opens new branch at the University of São Paulo

Drug Discovery World

French President Emmanuel Macron unveiled Institut Pasteur de São Paulo (IPSP) during a visit to the city on 27 March. Located on the campus of the University of São Paulo (USP) in a 2,000-square-meter building, the newest member of the Pasteur Network has the capacity to house some 100 scientists working in 17 laboratories, four of which are Biosafety Level Three (BSL3) facilities, as well as a bioinformatics unit and several items of multiuser equipment.

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Revolutionary molecular device unleashes potential for targeted drug delivery and self-healing materials

Science Daily: Pharmacology News

In a new breakthrough that could revolutionise medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.

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New postpartum depression drugs are here. Diagnosis, treatment hurdles still stand in the way.

BioPharma Drive: Drug Pricing

The first medicine approved for PPD, Sage’s Zulresso, never gained traction. The company is in the midst of launching its second, but long-standing challenges could slow uptake.

Treatment 124
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How to accelerate the development of advanced biotherapeutics

Drug Discovery World

Join DDW for this free event, ‘ Higher throughput bioanalytical methods accelerate the development and evaluation of advanced biotherapeutics ’, which is supported by Revvity. It will take place on 2 May at 3pm BST, 10am EDT, 4pm CEST and will be presented by Ron Morena, Manager in Analytical Bioassay at Tanvex Biopharma CDMO, along with and Dr Neha Mishra, Senior Scientist in the BioProduction R&D team, Revvity.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Using Internal Traffic Control Plans to Prevent Construction Worker Injuries and Fatalities in Work Zones

NIOSH Science Blog: Drugs

Struck-by injuries are the leading cause of nonfatal injuries and second most common cause of fatalities among construction workers. From 2011 to 2022, there were 1,462 fatal occupational injuries that occurred at road construction sites.[1] Of these, 68% (n=1,000) were among workers in the construction industry (See figure) followed by workers in transportation and warehousing (11%; n=168) and professional and business services (9%; n=132) industries.

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New drug prevents flu-related inflammation and lung damage

Science Daily: Pharmacology News

Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.

Virus 122

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Does the time of day you move your body make a difference to your health?

Science Daily: Pharmacology News

Undertaking the majority of daily physical activity in the evening is linked to the greatest health benefits for people living with obesity, according to researchers who followed the trajectory of 30,000 people over almost 8 years.

Research 116
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Vertex to buy kidney disease drugmaker Alpine for $4.9B

BioPharma Drive: Drug Pricing

The deal, which company CEO Reshma Kewalramani described as “just the right fit,” is the largest acquistion in Vertex’s 35-year history.

Disease 120
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Breakthrough for next-generation digital displays

Science Daily: Pharmacology News

Researchers have developed a digital display screen where the LEDs themselves react to touch, light, fingerprints and the user's pulse, among other things. Their results could be the start of a whole new generation of displays for phones, computers and tablets.

Research 111
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Ozempic, Wegovy Won't Boost Thyroid Cancer Risk: Study

Drugs.com

WEDNESDAY, April 10, 2024 -- Wegovy, Ozempic and other drugs known as GLP-1 analogues have become wildly popular for controlling diabetes and helping folks lose weight.There were concerns that longer term use of the drugs might raise users' odds.

Drugs 98
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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The hidden role of the Milky Way in ancient Egyptian mythology

Science Daily: Pharmacology News

Astrophysicists shed light on the relationship between the Milky Way and the Egyptian sky-goddess Nut. The paper draws on ancient Egyptian texts and simulations to argue that the Milky Way might have shone a spotlight, as it were, on Nut's role as the sky. It proposes that in winter, the Milky Way highlighted Nut's outstretched arms, while in summer, it traced her backbone across the heavens.

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New Investigational Drug, Olezarsen, Could Slash Blood Triglyceride Levels

Drugs.com

WEDNESDAY, April 10, 2024 -- A new drug can slash triglyceride levels nearly in half by targeting a genetic driver of high fat levels in the bloodstream, researchers said. The injectable drug, olezarsen, lowered triglyceride levels by 49% at the 50.

Drugs 98
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Connecting lab-grown brain cells provides insight into how our own brains work

Science Daily: Pharmacology News

Researchers have developed a technique to connect lab-grown neural 'organoids' (three-dimensional developmental brain-like structures grown from human stem cells) using axonal bundles, similar to the connections between regions in the human brain. This technique allows brain networks to be better represented experimentally in the lab, and will improve understanding and studies of network-related brain disorders.

Research 111
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New Drug Could Slash Blood Triglyceride Levels

Drugs.com

WEDNESDAY, April 10, 2024 -- A new drug can slash triglyceride levels nearly in half by targeting a genetic driver of high fat levels in the bloodstream, researchers said.The injectable drug, olezarsen, lowered triglyceride levels by 49% at the 50.

Drugs 98
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Researchers discover how we perceive bitter taste

Science Daily: Pharmacology News

A new study reveals the detailed protein structure of the TAS2R14, a bitter taste receptor that allows us to perceive bitter taste. In addition to solving the structure of this taste receptor, the researchers were also able to determine where bitter-tasting substances bind to TAS2R14 and how they activate them. The findings may lead to the development of drugs that targeting taste receptors.

Research 107
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Company Behind Defective CPAP Machines Must Make Changes Before U.S. Production Resumes

Drugs.com

WEDNESDAY, April 10, 2024 -- Phillips Respironics, the company responsible for the recall of millions of defective sleep apnea machines since 2021, must overhaul its production of the machines before it can resume making them in the United States,

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How the body switches out of 'fight' mode

Science Daily: Pharmacology News

Cortisone and other related glucocorticoids are extremely effective at curbing excessive immune reactions. But previously, astonishingly little was known about how they exactly do that. Researchers have now explored the molecular mechanism of action in greater detail. As the researchers report, glucocorticoids reprogram the metabolism of immune cells, activating the body's natural 'brakes' on inflammation.

Research 106
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Black and Native Americans Hit Hardest by 'Deaths of Despair'

Drugs.com

WEDNESDAY, April 10, 2024 -- More middle-aged Black and Native Americans are now falling prey to “deaths of despair” than whites, a new study finds.These deaths -- from suicide, drug overdose and alcoholic liver disease -- initially had been.

Disease 98
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An Urgent Call to Address Work-related Psychosocial Hazards and Improve Worker Well-being

NIOSH Science Blog: Drugs

Work-related psychosocial hazards are factors in the work environment that can cause stress, strain, or interpersonal problems for the worker. This has the potential to cause physical and psychological harm. Work-related psychosocial hazards are on the verge of surpassing many other occupational hazards in terms of their contribution to poor health, injury, disability, and costs.[1][2][3][4] The extensive and cumulative impacts of these exposures represent an alarming public health problem that

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Arthritis Can Often Follow ACL Surgeries in Young Adults

Drugs.com

WEDNESDAY, April 10, 2024 -- Early-onset arthritis may hit as many as one in every four young people who undergo anterior cruciate ligament (ACL) reconstruction surgeries, new research warns.The arthritic pain emerges within 6 to 12 months.

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Pacific cities much older than previously thought

Science Daily: Pharmacology News

New evidence of one of the first cities in the Pacific shows they were established much earlier than previously thought, according to new research. The study used aerial laser scanning to map archaeological sites on the island of Tongatapu in Tonga, showing Earth structures were being constructed in Tongatapu around AD 300.

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AI May Bring a Better Blood Test for Ovarian Cancer

Drugs.com

WEDNESDAY, April 10, 2024 -- Using AI to track fragments of tumor-associated DNA in the blood, scientists say they may be close to an accurate test for a silent killer: Ovarian cancer.It's the fifth leading cause of cancer death in the United.

DNA 98
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3D mouth of an ancient jawless fish suggests they were filter-feeders, not scavengers or hunters

Science Daily: Pharmacology News

Early jawless fish were likely to have used bony projections surrounding their mouths to modify the mouth's shape while they collected food. Experts have used CT scanning techniques to build up the first 3D pictures of these creatures, which are some of the earliest vertebrates (animals with backbones) in which the mouth is fossilized. Their aim was to answer questions about feeding in early vertebrates without jaws in the early Devonian epoch -- sometimes called the Age of Fishes -- around 400

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EPA Sets Strict Limit on PFAS 'Forever Chemicals' in U.S. Drinking Water

Drugs.com

WEDNESDAY, April 10, 2024 -- The Environmental Protection Agency announced Wednesday that it has finalized a first-ever rule that will drastically lower the amount of PFAS, also known as "forever chemicals," in the nation's drinking.

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Unleashing Flexibility: How SFCC Enables a Composable Commerce Experience

Perficient: Drug Development

The winds of change are blowing in the world of commerce, and composable architecture is taking center stage. Businesses are ditching monolithic platforms and embracing the freedom to mix and match best-of-breed solutions to create unique and engaging shopping experiences using MACH and Composable architecture. Composable commerce takes headless architecture further.

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Teens with Anxiety, Mood Disorders Less Likely to Get Driver's License

Drugs.com

WEDNESDAY, April 10, 2024 -- Teenagers suffering from anxiety, depression or bipolar disorder are likely to have a tougher time getting their driver’s license, a new study finds.Teens and young adults with these types of mood disorders are 30%.

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Orphan Drug Designation for Rare Diseases

Cytel

Orphan drug designation is a regulatory status granted to pharmaceuticals developed for the treatment of rare diseases. It provides incentives to encourage the research, development, and approval of therapies targeting small patient populations.

Disease 59
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Many Older Americans Get Care Outside of Doctor's Office, Poll Finds

Drugs.com

WEDNESDAY, April 10, 2024 -- Most seniors have embraced “doc-in-a-box” strip mall clinics and urgent care centers as a means of getting prompt medical care, a new poll has found.About 60% of people ages 50 to 80 have visited an urgent care.

Doctors 96
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Redefining Antibody Specificity Profiling for IND

Fierce BioTech

Redefining Antibody Specificity Profiling for IND swheeler Wed, 04/10/2024 - 17:56 Thu, 06/06/2024 - 11:00 Resource Type Webinar Kris Raghavan, PhD Fernanda I. Staquicini, PhD Duration 60 minutes Assessment of antibody off-target reactivity is a regulatory requirement for clinical development. However, conventional screening methods, such as tissue cross-reactivity studies, are often ineffective in screening newer therapeutic modalities, and their predictive value for in vivo safety and toxicity

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Beta Blocker Meds May Not Help Some Heart Attack Survivors

Drugs.com

WEDNESDAY, April 10, 2024 -- Beta blockers appear to be useless when prescribed to heart attack survivors who aren't suffering from heart failure, a new clinical trial indicates.The study calls into question the routine of prescribing beta blockers.

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Antibody Profiling: Decoding the Humoral Immune System

Fierce BioTech

Antibody Profiling: Decoding the Humoral Immune System Antibody biomarkers are redefining precision medicine – from early diagnosis to patient stratification. Get your FREE white paper to understand the challenges in disease diagnosis, the impact of antibody biomarkers, and the nuances of antibody screening for biomarker discovery. jpiatt Wed, 04/10/2024 - 11:32 Antibody biomarkers are redefining precision medicine, from diagnosing diseases earlier to stratifying patients – download your FREE wh

Disease 52
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How to Write a User Story – Part 1

Perficient: Drug Development

This blog is the first post in a series about leveraging user stories to improve product outcomes. In this post, we will explore how to write compelling user stories to quickly deliver value to your customers. The User Story – Your Key to Unlocking Product Value Picture this. It’s demo day. You’re excited to finally see what the development team has been working on for weeks, and you’re confident this work will bring value to your customers.

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Straight to Market in an Autoinjector

Fierce BioTech

Straight to Market in an Autoinjector The use of prefilled syringes to administer biotherapeutics is beginning to gain traction because they offer a range of stability, efficacy, and patient safety benefits. Download this white paper to learn how Lonza has developed a novel workflow to ensure confidence regarding functionality in PFS and autoinjectors. jpiatt Wed, 04/10/2024 - 11:26 The use of prefilled syringes to administer biotherapeutics is beginning to gain traction because they offer a ran

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Composable Martech: Unpack the Stack

Perficient: Drug Development

It’s clear in 2024 that the martech spaces continues to adopt a composable mindset towards technology architectures. Traditional martech players are offering more flexible product offerings by decoupling architectures, breaking up large suites into independent composable products. Newer cloud-native pureplay and point solutions are offering extension points and turn-key integrations with other composable tools to fit nicely into new modern architectures.