Drug Discovery World

JUNE 6, 2023

A targeted drug combination for patients with a type of ovarian cancer could be nearly twice as effective as the next best treatment, according to interim results from a Phase II study. Researchers hope these results, which were presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, will lead to a new option for patients with advanced low-grade serous ovarian cancer (LGSOC), a rare form of the disease that has a poor response rate to current treatments.

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Drug Discovery Today

JUNE 6, 2023

Geneva’s position as a leading European life science hub makes it the ideal choice for Connect in Pharma

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Science 113

Drug Discovery World

JUNE 6, 2023

The US Food and Drug Administration (FDA) has approved Pfizer’s bivalent respiratory syncytial virus (RSV) prefusion F (RSVpreF) vaccine Abrysvo in individuals 60 years and older. Abrysvo is unadjuvanted and composed of two preF proteins selected to optimise protection against RSV A and B strains and was observed to be safe and effective. “A vaccine to help prevent RSV had been an elusive public health goal for more than half a century.

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BioPharma Drive: Drug Pricing

JUNE 6, 2023

Having taken the rare step of filing for approval over protest, Brainstorm will get another chance to make a case for its drug NurOwn during a Sept. 27 meeting of cell, tissue and gene therapy experts.

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Therapies FDA Drugs 101

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JUNE 6, 2023

Pangaea Data has been awarded a strategic partnership by the newly established Mental Health Research for Innovation Centre (M-RIC). Pangaea is a provider of a novel artificial intelligence (AI)-driven product for characterising patients by automatically discovering clinical signatures for 4,000 hard-to-diagnose conditions in an evolving, privacy-preserving and scalable manner.

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ProRelix Research

JUNE 6, 2023

Being the second most populous country in the world with skilled labor and good infrastructure, India is a favorable destination for clinical trials for a wide variety of diseases. However, […] The post Changes to CDSCO’s Rules for Clinical Trials in India: New Drugs & Clinical Trial Rules 2019 appeared first on ProRelix Research.

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Clinical Trials Trials Drugs Disease 98

Drug Target Review

JUNE 6, 2023

Discoveries in recent years have firmly established immunotherapy as a major step forward in how we understand and treat cancer. We are in an era of immuno-oncology (IO) revolution with many approved therapies now available to treat a broad range of cancers. In this IO arena, we continue to search for additional treatments that can further benefit patients.

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Drug Discovery World

JUNE 6, 2023

DDW’s Megan Thomas provides highlights from AACR 2023, the American Association of Cancer Research’s annual meeting from 14-19 April 2023 in Orlando, Florida, US. Meet the incoming AACR President Having said goodbye and thank you to Dr Lisa Coussens, AACR President for 2022-2023, Dr Philip Greenberg was inaugurated as President at this year’s meeting to serve for the 2023-2024 period.

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BioPharma Drive: Drug Pricing

JUNE 6, 2023

The biotech has raised about $65 million to test two ways to deliver larger genes into the body, each of which could help gene therapy treat more diseases.

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Drug Discovery World

JUNE 6, 2023

Positive results from the ADAURA Phase III trial showed AstraZeneca’s Tagrisso (osimertinib) demonstrated a statistically significant and clinically meaningful improvement in overall survival (OS) compared to placebo. The trial assessed osimertinib as an adjuvant treatment of patients with early-stage (IB, II and IIIA) epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC) after complete tumour resection with curative intent.

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Clinical Trials

BioPharma Drive: Drug Pricing

JUNE 6, 2023

Dramatically positive trial data for AstraZeneca’s Tagrisso capped an important conference for the British drugmaker, while Gilead built a stronger case for its cell therapy Yescarta.

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Therapies Trials 94

Drug Discovery World

JUNE 6, 2023

BenevolentAI, developers of AI that accelerates biopharma discovery, has delivered BEN-34712, its pre-clinical candidate for the potential treatment of amyotrophic lateral sclerosis (ALS). BEN-34712 is an oral, potent and selective brain penetrant RARɑ? (retinoic acid receptor alpha beta) biased agonist and will now enter investigational new drug (IND)-enabling studies.

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addgene Blog

JUNE 6, 2023

There are a lot of viruses out there – most of which we would all like to steer clear of! However, a subset of viruses are commonly used in the lab as tools and we all might benefit from getting to know them a little better. Here we will discuss the four most commonly used lab viruses: gamma-retrovirus, lentivirus, adenovirus, and adeno-associated virus.

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Virus 65

BioPharma Drive: Drug Pricing

JUNE 6, 2023

Agency scientists raised no major red flags in their review of the antibody medicine in documents posted ahead of a Thursday meeting of FDA advisers.

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FDA Drugs 69

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

On Medicine

JUNE 6, 2023

Squeeze to Swallow Chest infections and pneumonia are common causes of admission to the hospital for older people. 90% of cases may be due to the inhalation of infected saliva or food/liquid. Many older adults do not recognise that they have a problem with their swallowing. © Brigitte Bonaposta / Fotolia Airway Protection The pharynx (throat) is a crucial part of human anatomy performing both swallowing and breathing.

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Hospitals Research Clinical Trials Trials 59

Perficient: Drug Development

JUNE 6, 2023

The BattleBots World Championship VII tournament recently concluded, and a new reigning champ has been crowned. Unfortunately for Minotaur fans, team Minotaur came up just short of the Giant Nut trophy after suffering their first loss of the season. Despite losing in the quarterfinals battle against SawBlaze, Minotaur had an outstanding run this season.

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BioPharma Drive: Drug Pricing

JUNE 6, 2023

The drugmaker’s lawsuit claims the new pricing powers granted by the Inflation Reduction Act are unconstitutional and “tantamount to extortion.

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Drugs 58

Perficient: Drug Development

JUNE 6, 2023

Content M anagement S ystem is software for users to develop business website s and application s without extensive technical knowledge. It allows professionals such as business owners and marketers to create, manage, modify , and publish digital content effortlessly. There are over 80 Content Management Systems to choose from and selecting one that suits your business needs is important.

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Marketing Production Government 59

Fierce BioTech

JUNE 6, 2023

Capture the Magic: Enhancing cfDNA Open-format Isolation for Robust, Reproducible Downstream Analysis pesurya Tue, 06/06/2023 - 14:16 Wed, 07/12/2023 - 11:00 Resource Type Webinar Duration 60 Minutes There has been a significant need for a reliable, consistent plasma collection and DNA extraction workflow in the field of liquid biopsy. Current methods of blood collection and extraction chemistries are often suboptimal, resulting in compromised integrity of the cell-free DNA (cfDNA) fraction.

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DNA Research 52

Perficient: Drug Development

JUNE 6, 2023

Introduction: In the world of cloud storage, effective data management is crucial to optimize costs and ensure efficient storage utilization. Amazon S3, a popular and highly scalable object storage service provided by Amazon Web Services (AWS), offers a powerful feature called Lifecycle Configuration. With S3 Lifecycle Configuration, you can automate the process of moving objects between different storage classes or even deleting them based on predefined rules.

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Compliance 59

Predictive Oncology

JUNE 6, 2023

Chief Executive Officer Raymond Vennare and Chief Business Officer Pamela Bush, Ph.D., MBA, were invited onto the “I am BIO” podcast to share their thoughts on how the company is standing up for science. This comes in the middle of the BIO International Convention in Boston where Predictive Oncology was also invited to present. Listen to Pamela and Raymond’s interviews below: Pamela’s Interview Raymond’s Interview The post “I am BIO” podcast features Predictive Oncology l

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International Science 52

Perficient: Drug Development

JUNE 6, 2023

If you have installed Google Analytics 4 recently or already have it for your site, you might have experienced some difficulties in the debugger. For instance, 2 or 3 instances of the same event appear. If we reload the page, at first, it will disappear and then they start to duplicate again. Common reasons why events log twice in Google Analytics 4: One such common reason is the event could be logged in multiple GA4 accounts.

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Production 59

Broad Institute

JUNE 6, 2023

Stanley Center Investigators By Rose Circeo June 6, 2023 Breadcrumb Home Stanley Center for Psychiatric Research Stanley Center Investigators Human Genetics Ben Neale (MGH) Director of Human Genetics Hailiang Huang (MGH) Associate Director of Human Genetics Elise Robinson (HSPH) Associate Director of Human Genetics Lori Chibnik (HSPH) Mark Daly (MGH) Hilary Finucane (MGH) Bizu Gelaye (HSPH) Karestan Koenen (HSPH) Alicia Martin (MGH) Steve McCarroll (HMS) Ralda Nehme (Broad) Aarno Palotie (MGH) M

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Research 52

BMG Labtech

JUNE 6, 2023

The “amyloid hypothesis” Early research into Alzheimer’s disease indicated the importance of amyloid-beta as a crucial component of senile plaques in the brain. In parallel, the tau protein was revealed as the main component of neurofibrillary tangles in patients with the disease.

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Disease Research 52

Covalent Modifiers

JUNE 6, 2023

Cravatt, B.; Njomen, E.; Hayward, R.; DeMeester, K.; Ogasawara, D.; Dix, M.; Nguyen, T.; Ashby, P.; Simon, G.; Schreiber, S.; Melillo, B. ChemRxiv 2023 [link] Covalent chemistry is a versatile approach for expanding the ligandability of the human proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by electrophilic compounds through competition with broadly reactive probes.

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Small Molecule 52

BenchSci

JUNE 6, 2023

As we honor and recognize Pride Month, it’s personally important to acknowledge the unique intersections of my identity and celebrate the resilience of the 2SLGBTQIA+ community. At BenchSci, I am proud to work for an organization that allows me the choice to self-identify my sexual orientation, race, and other aspects of my identity. Self-identification also serves as a catalyst for visibility, helping to increase representation and recognition of the diverse range of other Black LGBTQ+ individu

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Fierce BioTech

JUNE 6, 2023

The role of biopharma & digital health partnerships in supporting patients with rare diseases to live longer and fuller lives pesurya Tue, 06/06/2023 - 13:57 Thu, 07/20/2023 - 11:00 Resource Type Webinar Tim Broke-Smith Colin Lake Duration 60 Minutes Join senior executives from UCB, a global biopharmaceutical company, and Huma, a leading global digital health company, to discuss how their innovative partnership offers a digital technology solution to help patients with rare diseases, better und

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Disease 52

Drug Patent Watch

JUNE 6, 2023

This chart shows the drugs with the most patents in Poland. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.… The post Which pharmaceutical drugs have the most drug patents in Poland? appeared first on DrugPatentWatch - Make Better Decisions.

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Pharmaceuticals Drugs 52

Perficient: Drug Development

JUNE 6, 2023

SEO is a vital aspect of any ecommerce application, as having a good SEO ranking increases traffic to your website and brings in revenue opportunities. Optimizely Configured Commerce (formerly Optimizely B2B Commerce) comes packaged with SEO features built-in, providing SEO configuration settings without requiring development code. Don’t worry if the native capabilities do not fit your needs, as there are extension points available to customize your version to achieve your desired outcome.

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Engineering Production Packaging 52

Drug Patent Watch

JUNE 6, 2023

Annual Drug Patent Expirations for AUSTEDO Austedo is a drug marketed by Teva Branded Pharm and is included in one NDA. It is available from one supplier. There are nine… The post New patent for Teva Branded drug AUSTEDO appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 52

Fierce BioTech

JUNE 6, 2023

Accelerating the Development of Nucleic Acid Therapies at Harwell Science and Innovation Campus Harwell Campus offers rich opportunities for pioneering NAT technology on all fronts, and the campus is attracting biotechnology companies of all sizes – from Moderna to start-ups to Government research institutes and accelerators. Download here! jsabatino Tue, 06/06/2023 - 09:31 Harwell Campus offers rich opportunities for pioneering NAT technology on all fronts, and the campus is attracting biotechn

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Science Molecular Biology Therapies Government 52

Drug Patent Watch

JUNE 6, 2023

FYCOMPA (perampanel) Eisai inc Patent: 6,949,571 Expiration: Jun 8, 2023 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.com or… The post Drug Patent Expirations for the Week of June 4, 2023 appeared first on DrugPatentWatch - Make Better Decisions.

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Drug Channels

JUNE 6, 2023

Time for the annual update to the Drug Channels Institute (DCI) analysis of pharmacist salaries and employment. Pharmacist employment in retail settings rebounded to its pre-pandemic levels, while non-retail settings—hospitals, physician offices, outpatient centers, and home healthcare—continued to add positions. For 2022, nearly half of pharmacists now work in non-retail practice settings.

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Pharmacy Hospitals Drugs 52

BioPharma Drive: Drug Pricing

JUNE 6, 2023

Gurnet Point Capital and Novo Holdings aim to take Paratek private in a deal that highlights the challenges small biotechs face selling new antibiotics.

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