Drug Discovery World

MAY 7, 2024

DDW Editor Reece Armstrong speaks to David Chau , Global Bioprocess Application Specialist, Separation and Purification Sciences Division, 3M, about challenges in producing monoclonal antibodies (mAbs) and how single-use technologies can simplify processes. RA: What are some of the current limitations for producing mAbs? DC: For the past few decades, there have been many advancements in the biotechnology space.

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BioPharma Drive: Drug Pricing

MAY 7, 2024

Pfizer said the patient, a young boy who was treated earlier last year, had died suddenly. The company is working with trial researchers to investigate further.

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Drug Discovery World

MAY 7, 2024

In this webinar, you will hear from Dr Jill O’Donnell-Tormey, CEO and Director of Scientific Affairs at Cancer Research Institute; Dr Sheila Keating, VP of Immunology at Gigagen; as well as event sponsors Dr Milind Nigam, Leader – Scientific Solutions Consulting at Benchling, and Dr Paola Genevini, Technical Sales Specialist at Bio-Rad. Dr O’Donnell-Tormey will address the opportunities, innovations and challenges in the therapeutic antibody space.

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Marketing Engineering Therapies Drugs 130

Science Daily: Pharmacology News

MAY 7, 2024

The world's largest study of cerebral palsy (CP) genetics has discovered genetic defects are most likely responsible for more than a quarter of cases in Chinese children, rather than a lack of oxygen at birth as previously thought.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

MAY 7, 2024

Traditional drug discovery is time-consuming and expensive, and numerous industry studies are showing a year-on-year decrease in return on investment from R&D efforts across the board. Join DDW and FUJIFILM Wako on 24 May 3PM BST to learn more about how AI-AAM (AI-Amino-Acid Mapping), its new proprietary scaffold-hopping method based on AI and chemical simulation techniques, can be used to address this challenge, accelerating the identification of hit compounds and improvements in compound s

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Small Molecule Drugs Research Marketing 130

Drugs.com

MAY 7, 2024

TUESDAY, May 7, 2024 -- Lab tests of counterfeit oxycodone (Oxycontin) pills seized by police in Rhode Island in 2022 found 99.3% also contained dangerous fentanyl. It was typically mixed with another potentially deadly drug, xylazine.Both.

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Drugs 107

Science Daily: Pharmacology News

MAY 7, 2024

Move over, graphene. There's a new, improved two-dimensional material in the lab. Borophene, the atomically thin version of boron first synthesized in 2015, is more conductive, thinner, lighter, stronger and more flexible than graphene, the 2D version of carbon. Now, researchers have made the material potentially more useful by imparting chirality -- or handedness -- on it, which could make for advanced sensors and implantable medical devices.

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Research 105

Nvidia Developer: Drug Discovery

MAY 7, 2024

Missed GTC or want to replay your favorite training labs? Find it on demand with the NVIDIA GTC Training Labs playlist. Missed GTC or want to replay your favorite training labs? Find it on demand with the NVIDIA GTC Training Labs playlist.

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Bioinformatics Science Drugs 98

Science Daily: Pharmacology News

MAY 7, 2024

Researchers developed a silk fabric, which is barely thicker than a human hair, that can suppress unwanted noise and reduce noise transmission in a large room.

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Research 109

Drugs.com

MAY 7, 2024

TUESDAY, May 7, 2024 -- An artificial intelligence (AI) program trained to analyze cardiac ultrasounds can detect abnormal heart rhythms that a doctor is apt to overlook, a new study reports."Atrial fibrillation can come and go, so it might not be.

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Doctors 95

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

MAY 7, 2024

Finding reliable, eco-friendly power sources is crucial as our world grapples with increasing energy needs and the urgent call to combat climate change. Solar energy offers one solution, with scientists devising ever more efficient materials for capturing sunlight.

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Drugs.com

MAY 7, 2024

TUESDAY, May 7, 2024 -- Planters peanut products sold at Publix and Dollar Tree in five states are being recalled due to the risk of Listeria contamination, maker Hormel announced.The products are Planters Honey Roasted Peanuts (4 ounces) and.

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Production 94

Science Daily: Pharmacology News

MAY 7, 2024

Researchers have invented a breakthrough technique for manufacturing highly purified silicon that brings powerful quantum computers a big step closer.

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Research 104

Drugs.com

MAY 7, 2024

TUESDAY, May 7, 2024 -- “New car smell” is a beloved benefit of buying a new vehicle.However, at least part of that scent could be due to toxic carcinogens released by flame retardants, a new study says.Flame retardant chemicals added to seat.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Channels

MAY 7, 2024

It's time for Drug Channels ’ annual update of vertical integration among insurers, PBMs, specialty pharmacies, and providers within U.S. drug channels. Below you’ll find our latest illustration of the major vertical business relationships among the largest companies along with some of the notable activity since our previous update. These organizations continue to exert greater control over patient access, sites of care/dispensing, and pricing, although some have started to unwind their vert

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Specialty Pharmacies Pharmacy Drugs 88

Drugs.com

MAY 7, 2024

TUESDAY, May 7, 2024 -- Parents can be very effective buzzkills for their teens, just by letting kids know they’re being closely watched, a new study reports.Teenagers are less likely to drink, smoke or use drugs when parents keep tabs on their.

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Drugs 87

BioPharma Drive: Drug Pricing

MAY 7, 2024

The $200 million round is the latest evidence that surging interest in autoimmune disease cell therapies could expand to include developers of bispecific antibodies, too.

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Therapies Disease 65

Drugs.com

MAY 7, 2024

TUESDAY, May 7, 2024 -- People who carry two copies of the gene mutation most strongly implicated in Alzheimer’s disease are almost certain to develop brain changes related to the degenerative disorder, a new study says.A single mutated APOE4.

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Disease 85

BioPharma Drive: Drug Pricing

MAY 7, 2024

The company is using what it claims is the largest database of viral protein structures to unearth medicines for a range of diseases, said CEO and Flagship origination partner Lovisa Afzelius.

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Virus Disease Drugs 62

Drugs.com

MAY 7, 2024

TUESDAY, May 7, 2024 -- Researchers say they’ve identified a human “neural compass” -- a pattern of brain activity that helps prevent humans from becoming lost.For the first time, the internal compass humans use to orient themselves and.

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BioPharma Drive: Drug Pricing

MAY 7, 2024

Weeks after a safety setback derailed its lead candidate, the company has treated the first participant in a trial of its heart disease treatment Verve-102.

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Therapies Trials Treatment Disease 65

Drugs.com

MAY 7, 2024

TUESDAY, May 7, 2024 -- An experimental anti-nicotine drug appears to help people quit vaping, a new study says. Cytisinicline is a naturally occurring plant-based substance that binds to nicotine receptors in the brain, reducing a person’s.

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Drugs 59

BioPharma Drive: Drug Pricing

MAY 7, 2024

After delaying an approval decision for Lilly’s donanemab, the agency now intends to hold an advisory committee meeting on June 10.

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FDA Drugs 70

Cytel

MAY 7, 2024

Here we explore the evolution and impact of market exclusivity policies in the EU and US, highlighting their role in fostering innovation and accessibility in rare disease treatment. Market exclusivity for orphan drugs traces back to the early 1980s in the United States, with the landmark Orphan Drug Act of 1983. This legislation emerged from a pressing need to address “orphan” conditions, i.e., conditions that were abandoned or “orphaned” by the pharmaceutical industry, deemed unprofitable due

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thought leadership

MAY 7, 2024

Are You Ready for Mandatory EU Health Technology Assessment Regulation (HTAR) Implementation Beginning January 2025? Pharmaceutical companies need to be prepared for the new European Health Technology Assessment Regulation (HTAR), which will take effect in January 2025. The aim of the HTAR is to accelerate access to new drugs and reduce unnecessary duplication of work.

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Drug Target Review

MAY 7, 2024

Why are biomarkers particularly critical in the context of rare diseases? Developing novel therapeutic approaches for rare diseases poses inherent challenges due to the limited populations available for testing. Small patient populations often result in difficulty in determining a significant effect of a therapy, given the low confidence power associated with the statistics.

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Drug Patent Watch

MAY 7, 2024

Annual Drug Patent Expirations for EDURANT Edurant is a drug marketed by Janssen Prods and is included in two NDAs. It is available from one supplier.

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Common Sense for Drug Policy Blog

MAY 7, 2024

Local Police Departments in the US "As of December 31, 2020, more than 14,700 general-purpose law enforcement agencies in the United States employed about 708,000 full-time sworn officers and 348,000 full-time civilians. Local police departments accounted for about 80% (11,800) of the general-purpose agencies, employing nearly 67% (473,000) of full-time sworn personnel and 36% (126,000) of full-time civilian personnel (figure 1, table 1). 1 "The total number of full-time personnel in local polic

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PPD

MAY 7, 2024

The European Union (EU) is on the verge of a significant shift as it prepares to implement new health technology assessment (HTA) regulations in 2025. This change promises a more efficient use of resources, improved patient access to innovative health technologies and strengthened HTAs across the EU. However, it also presents challenges and uncertainties, particularly in relation to the Population, Intervention, Comparator(s) and Outcomes (PICO) framework underpinning the new Joint Clinical Asse

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Regulations Pharmaceutical Companies International Pharmaceuticals 52

Common Sense for Drug Policy Blog

MAY 7, 2024

Law Enforcement Personnel in the US "In 2020, about 1,056,000 full-time personnel worked for general-purpose law enforcement agencies at the state, county, or local level (table 2). Of these personnel, almost 57% worked for local police departments. Of the 708,000 full-time sworn officers employed across the country, about 67% worked for local police departments.

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Fierce BioTech

MAY 7, 2024

Duchenne Muscular Dystrophy - Global Clinical Trial Landscape Duchenne Muscular Dystrophy is a rare genetic disorder characterized by progressive muscle weakness and skeletal degeneration, impacting approximately 1 in 5,000 males globally. Explore the latest trends in Duchenne Muscular Dystrophy clinical trials and discover key findings and analysis from this comprehensive report. jkarimi Tue, 05/07/2024 - 12:36 Duchenne Muscular Dystrophy is a rare genetic disorder characterized by progressive

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Clinical Trials Trials Research 52

Common Sense for Drug Policy Blog

MAY 7, 2024

Spending on Local Police Departments in the US "In 2020, nearly $80 billion was budgeted for local police departments nationwide ( table 15 ). The estimated 110 departments serving 250,000 or more residents in 2020 accounted for 43% of this funding. (See table 4.) These departments represented fewer than 1% of all local police departments but employed about 41% of all full-time sworn local officers.

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Perficient: Drug Development

MAY 7, 2024

Providing feedback is essential for driving innovation, improving technical and behavioral skills, and strengthening team dynamics. The EAST methodology (Easy, Attractive, Social, Timely) offers a powerful framework for delivering feedback in a way that is more easily received and applied, which can help promote an environment of continuous growth. By applying these principles, individuals can overcome common challenges in feedback communication, transforming interactions into opportunities for

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Drugs.com

MAY 7, 2024

TUESDAY, May 7, 2024 -- A small, implantable heart pump could help children await heart transplants at home rather than languishing in a hospital, according to a new study.The pump is surgically attached to augment the heart’s blood-pumping.

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Hospitals 52